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SMG8 SMG8 nonsense mediated mRNA decay factor [ Homo sapiens (human) ]

Gene ID: 55181, updated on 26-Nov-2021

Summary

Official Symbol
SMG8provided by HGNC
Official Full Name
SMG8 nonsense mediated mRNA decay factorprovided by HGNC
Primary source
HGNC:HGNC:25551
See related
Ensembl:ENSG00000167447 MIM:613175
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALKUS; C17orf71
Expression
Ubiquitous expression in ovary (RPKM 5.9), testis (RPKM 5.7) and 25 other tissues See more
Orthologs
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Genomic context

See SMG8 in Genome Data Viewer
Location:
17q22
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (59210035..59215230)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (57287396..57292591)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene microRNA 301a Neighboring gene proline rich 11 Neighboring gene speedy/RINGO cell cycle regulator family member E22, pseudogene Neighboring gene glycerophosphodiester phosphodiesterase domain containing 1 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
ALZAHRANI-KUWAHARA SYNDROME
MedGen: CN296411 OMIM: 619268 GeneReviews: Not available
Compare labs
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10587

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein SMG8
Names
amplified in breast cancer gene 2 protein
protein smg-8 homolog
smg-8 homolog, nonsense mediated mRNA decay factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018149.7NP_060619.4  protein SMG8

    See identical proteins and their annotated locations for NP_060619.4

    Status: VALIDATED

    Source sequence(s)
    AF349467, AL834490
    Consensus CDS
    CCDS11615.1
    UniProtKB/Swiss-Prot
    Q8ND04
    Related
    ENSP00000300917.4, ENST00000300917.10
    Conserved Domains (1) summary
    pfam10220
    Location:42985
    Smg8_Smg9

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    59210035..59215230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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