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Foxp4 forkhead box P4 [ Mus musculus (house mouse) ]

Gene ID: 74123, updated on 9-Dec-2024

Summary

Official Symbol
Foxp4provided by MGI
Official Full Name
forkhead box P4provided by MGI
Primary source
MGI:MGI:1921373
See related
Ensembl:ENSMUSG00000023991 AllianceGenome:MGI:1921373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mFKHLA; 1200010K03Rik; 2310007G05Rik
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic foregut morphogenesis; lung secretory cell differentiation; and negative regulation of lung goblet cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; hindlimb digit mesenchyme; and skeleton. Orthologous to human FOXP4 (forkhead box P4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in stomach adult (RPKM 50.9), colon adult (RPKM 45.3) and 27 other tissues See more
Orthologs
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Genomic context

See Foxp4 in Genome Data Viewer
Location:
17 C; 17 23.99 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48178058..48235401, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47867133..47924632, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25201 Neighboring gene nuclear encoded rRNA 5S 28 Neighboring gene STARR-seq mESC enhancer starr_42731 Neighboring gene STARR-seq mESC enhancer starr_42732 Neighboring gene STARR-seq mESC enhancer starr_42734 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48037747-48037856 Neighboring gene STARR-positive B cell enhancer ABC_E8679 Neighboring gene STARR-positive B cell enhancer ABC_E9170 Neighboring gene macrophage migration inhibitory factor, pseudogene 8 Neighboring gene predicted gene, 29938

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
forkhead box protein P4
Names
fork head-related protein like A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110824.2NP_001104294.1  forkhead box protein P4 isoform 1

    See identical proteins and their annotated locations for NP_001104294.1

    Status: VALIDATED

    Source sequence(s)
    AC113536, AC164306
    Consensus CDS
    CCDS50137.1
    UniProtKB/TrEMBL
    A0A0R4J161, D3Z726
    Related
    ENSMUSP00000094916.3, ENSMUST00000097311.9
    Conserved Domains (3) summary
    smart00339
    Location:472544
    FH; FORKHEAD
    COG5025
    Location:370565
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:309376
    FOXP-CC; FOXP coiled-coil domain
  2. NM_001110825.2NP_001104295.1  forkhead box protein P4 isoform 2

    See identical proteins and their annotated locations for NP_001104295.1

    Status: VALIDATED

    Source sequence(s)
    AC113536, AC164306
    Consensus CDS
    CCDS50136.1
    UniProtKB/TrEMBL
    A0A0R4J1I5, D3Z726
    Related
    ENSMUSP00000108887.2, ENSMUST00000113262.2
    Conserved Domains (2) summary
    pfam00250
    Location:460539
    Forkhead; Forkhead domain
    pfam16159
    Location:309376
    FOXP-CC; FOXP coiled-coil domain
  3. NM_001403969.1NP_001390898.1  forkhead box protein P4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113536, AC164306
    UniProtKB/TrEMBL
    D3Z726
  4. NM_001403970.1NP_001390899.1  forkhead box protein P4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113536, AC164306
    UniProtKB/TrEMBL
    D3Z726
  5. NM_028767.3NP_083043.2  forkhead box protein P4 isoform 3

    See identical proteins and their annotated locations for NP_083043.2

    Status: VALIDATED

    Source sequence(s)
    AC113536, AC164306
    Consensus CDS
    CCDS50135.1
    UniProtKB/TrEMBL
    D3Z726
    Related
    ENSMUSP00000108890.2, ENSMUST00000113265.8
    Conserved Domains (2) summary
    pfam00250
    Location:459538
    Forkhead; Forkhead domain
    pfam16159
    Location:308375
    FOXP-CC; FOXP coiled-coil domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    48178058..48235401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317686.2XP_017173175.1  forkhead box protein P4 isoform X1

    UniProtKB/TrEMBL
    D3Z726
    Conserved Domains (3) summary
    smart00339
    Location:479551
    FH; FORKHEAD
    COG5025
    Location:375572
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:309376
    FOXP-CC; FOXP coiled-coil domain
  2. XM_030250107.1XP_030105967.1  forkhead box protein P4 isoform X3

    UniProtKB/TrEMBL
    A0A0R4J161, D3Z726
    Conserved Domains (3) summary
    smart00339
    Location:472544
    FH; FORKHEAD
    COG5025
    Location:370565
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:309376
    FOXP-CC; FOXP coiled-coil domain
  3. XM_017317687.3XP_017173176.1  forkhead box protein P4 isoform X1

    UniProtKB/TrEMBL
    D3Z726
    Conserved Domains (3) summary
    smart00339
    Location:479551
    FH; FORKHEAD
    COG5025
    Location:375572
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:309376
    FOXP-CC; FOXP coiled-coil domain