Format

Send to:

Choose Destination

USF2 upstream transcription factor 2, c-fos interacting [ Homo sapiens (human) ]

Gene ID: 7392, updated on 18-Nov-2018

Summary

Official Symbol
USF2provided by HGNC
Official Full Name
upstream transcription factor 2, c-fos interactingprovided by HGNC
Primary source
HGNC:HGNC:12594
See related
Ensembl:ENSG00000105698 MIM:600390; Vega:OTTHUMG00000183182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIP; bHLHb12
Summary
This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in fat (RPKM 22.6), spleen (RPKM 20.0) and 25 other tissues See more
Orthologs

Genomic context

See USF2 in Genome Data Viewer
Location:
19q13.12
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (35268978..35279821)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35759896..35770724)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 187, member B pseudogene Neighboring gene lipolysis stimulated lipoprotein receptor Neighboring gene uncharacterized LOC105372380 Neighboring gene HNF4 motif-containing MPRA enhancer 344 Neighboring gene hepcidin antimicrobial peptide

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
upstream stimulatory factor 2
Names
c-fos interacting protein
class B basic helix-loop-helix protein 12
major late transcription factor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029241.1 RefSeqGene

    Range
    4986..15829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321150.1NP_001308079.1  upstream stimulatory factor 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AD000684, AI240594, AY147880
    Consensus CDS
    CCDS82329.1
    UniProtKB/Swiss-Prot
    Q15853
    Related
    ENSP00000368429.3, OTTHUMP00000271114, ENST00000379134.7, OTTHUMT00000465524
    Conserved Domains (2) summary
    cd00083
    Location:102164
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    TIGR04211
    Location:135202
    SH3_and_anchor; SH3 domain protein
  2. NM_003367.3NP_003358.1  upstream stimulatory factor 2 isoform 1

    See identical proteins and their annotated locations for NP_003358.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AD000684, AI240594, AY007087, BC049821, X90825
    Consensus CDS
    CCDS12452.1
    UniProtKB/Swiss-Prot
    Q15853
    Related
    ENSP00000222305.2, OTTHUMP00000271374, ENST00000222305.7, OTTHUMT00000466056
    Conserved Domains (2) summary
    cd00083
    Location:233295
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    TIGR04211
    Location:266339
    SH3_and_anchor; SH3 domain protein
  3. NM_207291.2NP_997174.1  upstream stimulatory factor 2 isoform 2

    See identical proteins and their annotated locations for NP_997174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AD000684, AI240594, AY007087, X90825
    Consensus CDS
    CCDS12453.1
    UniProtKB/Swiss-Prot
    Q15853
    Related
    ENSP00000340633.4, OTTHUMP00000271113, ENST00000343550.9, OTTHUMT00000465523
    Conserved Domains (2) summary
    cd00083
    Location:166228
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    TIGR04211
    Location:199272
    SH3_and_anchor; SH3 domain protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    35268978..35279821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259197.4XP_005259254.1  upstream stimulatory factor 2 isoform X2

    Related
    ENSP00000471511.1, OTTHUMP00000271376, ENST00000594064.5
    Conserved Domains (1) summary
    cd00083
    Location:233295
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  2. XM_024451684.1XP_024307452.1  upstream stimulatory factor 2 isoform X1

    Conserved Domains (2) summary
    cd00083
    Location:233346
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam06005
    Location:341385
    ZapB; Cell division protein ZapB
  3. XM_024451685.1XP_024307453.1  upstream stimulatory factor 2 isoform X3

    Conserved Domains (2) summary
    cd00083
    Location:166279
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam06005
    Location:274318
    ZapB; Cell division protein ZapB
  4. XM_017027199.1XP_016882688.1  upstream stimulatory factor 2 isoform X4

  5. XM_011527260.2XP_011525562.1  upstream stimulatory factor 2 isoform X5

  6. XM_011527261.2XP_011525563.1  upstream stimulatory factor 2 isoform X6

Support Center