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USF2 upstream transcription factor 2, c-fos interacting [ Homo sapiens (human) ]

Gene ID: 7392, updated on 5-May-2024

Summary

Official Symbol
USF2provided by HGNC
Official Full Name
upstream transcription factor 2, c-fos interactingprovided by HGNC
Primary source
HGNC:HGNC:12594
See related
Ensembl:ENSG00000105698 MIM:600390; AllianceGenome:HGNC:12594
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIP; bHLHb12
Summary
This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in fat (RPKM 22.6), spleen (RPKM 20.0) and 25 other tissues See more
Orthologs
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Genomic context

Location:
19q13.12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35268962..35279821)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37813633..37824489)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35759865..35770724)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 187, member B pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14461 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35738792-35739594 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35739595-35740396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35748323-35748823 Neighboring gene uncharacterized LOC105372380 Neighboring gene lipolysis stimulated lipoprotein receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35753027-35753725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14462 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35761221-35761960 Neighboring gene HNF4 motif-containing MPRA enhancer 344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35773293-35773802 Neighboring gene hepcidin antimicrobial peptide Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14466 Neighboring gene myelin associated glycoprotein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35795633-35796520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35802349-35802850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35802851-35803350

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
upstream stimulatory factor 2
Names
c-fos interacting protein
class B basic helix-loop-helix protein 12
major late transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029241.1 RefSeqGene

    Range
    4970..15829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321150.2NP_001308079.1  upstream stimulatory factor 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AD000684, AI240594, AY147880
    Consensus CDS
    CCDS82329.1
    UniProtKB/Swiss-Prot
    Q15853
    Related
    ENSP00000368429.3, ENST00000379134.7
    Conserved Domains (2) summary
    cd00083
    Location:102164
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    TIGR04211
    Location:135202
    SH3_and_anchor; SH3 domain protein
  2. NM_003367.4NP_003358.1  upstream stimulatory factor 2 isoform 1

    See identical proteins and their annotated locations for NP_003358.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AD000684, AI240594, AY007087, BC049821, X90825
    Consensus CDS
    CCDS12452.1
    UniProtKB/Swiss-Prot
    O00671, O00709, Q05750, Q07952, Q15851, Q15852, Q15853, Q6FI33, Q6YI47
    UniProtKB/TrEMBL
    B4DLJ1
    Related
    ENSP00000222305.2, ENST00000222305.8
    Conserved Domains (2) summary
    cd18923
    Location:229308
    bHLHzip_USF2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins
    pfam06005
    Location:290334
    ZapB; Cell division protein ZapB
  3. NM_207291.3NP_997174.1  upstream stimulatory factor 2 isoform 2

    See identical proteins and their annotated locations for NP_997174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AD000684, AI240594, AY007087, X90825
    Consensus CDS
    CCDS12453.1
    UniProtKB/Swiss-Prot
    Q15853
    Related
    ENSP00000340633.4, ENST00000343550.9
    Conserved Domains (2) summary
    cd18923
    Location:162241
    bHLHzip_USF2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins
    pfam06005
    Location:223267
    ZapB; Cell division protein ZapB

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    35268962..35279821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259197.5XP_005259254.1  upstream stimulatory factor 2 isoform X1

    UniProtKB/TrEMBL
    B4DLJ1
    Related
    ENSP00000471511.1, ENST00000594064.5
    Conserved Domains (1) summary
    cd18923
    Location:229308
    bHLHzip_USF2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins
  2. XM_011527260.3XP_011525562.1  upstream stimulatory factor 2 isoform X2

  3. XM_011527261.3XP_011525563.1  upstream stimulatory factor 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    37813633..37824489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321938.1XP_054177913.1  upstream stimulatory factor 2 isoform X1

  2. XM_054321939.1XP_054177914.1  upstream stimulatory factor 2 isoform X2

  3. XM_054321940.1XP_054177915.1  upstream stimulatory factor 2 isoform X3