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Usf2 upstream transcription factor 2 [ Mus musculus (house mouse) ]

Gene ID: 22282, updated on 26-Sep-2022

Summary

Official Symbol
Usf2provided by MGI
Official Full Name
upstream transcription factor 2provided by MGI
Primary source
MGI:MGI:99961
See related
Ensembl:ENSMUSG00000058239 AllianceGenome:MGI:99961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Usf-2; bHLHb12
Summary
Enables DNA binding activity. Involved in lipid homeostasis and positive regulation of transcription from RNA polymerase II promoter by glucose. Acts upstream of or within lactation; positive regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and sensory organ. Orthologous to human USF2 (upstream transcription factor 2, c-fos interacting). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 66.5), ovary adult (RPKM 53.4) and 28 other tissues See more
Orthologs
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Genomic context

See Usf2 in Genome Data Viewer
Location:
7 B1; 7 19.27 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30644673..30656777, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30945248..30956951, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene upstream transcription factor 2, pseudogene 1 Neighboring gene hepcidin antimicrobial peptide Neighboring gene lipolysis stimulated lipoprotein receptor Neighboring gene family with sequence similarity 187, member B Neighboring gene olfactory receptor 1359 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC91056

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
upstream stimulatory factor 2
Names
major late transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011680.2NP_035810.1  upstream stimulatory factor 2

    See identical proteins and their annotated locations for NP_035810.1

    Status: VALIDATED

    Source sequence(s)
    AC149055, AK146871
    Consensus CDS
    CCDS21118.1
    UniProtKB/Swiss-Prot
    Q64705, Q8VE59
    UniProtKB/TrEMBL
    A0A6P5PUF3
    Related
    ENSMUSP00000132256.2, ENSMUST00000058860.14
    Conserved Domains (2) summary
    cd18923
    Location:229308
    bHLHzip_USF2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins
    pfam06005
    Location:290334
    ZapB; Cell division protein ZapB

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30644673..30656777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539733.5XP_006539796.1  upstream stimulatory factor 2 isoform X1

    See identical proteins and their annotated locations for XP_006539796.1

    UniProtKB/Swiss-Prot
    Q64705
    UniProtKB/TrEMBL
    A0A6P5Q1C4
    Related
    ENSMUSP00000132021.2, ENSMUST00000108119.10
    Conserved Domains (2) summary
    pfam06005
    Location:223267
    ZapB; Cell division protein ZapB
    cl00081
    Location:162241
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily