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UGDH UDP-glucose 6-dehydrogenase [ Homo sapiens (human) ]

Gene ID: 7358, updated on 6-Jan-2019

Summary

Official Symbol
UGDHprovided by HGNC
Official Full Name
UDP-glucose 6-dehydrogenaseprovided by HGNC
Primary source
HGNC:HGNC:12525
See related
Ensembl:ENSG00000109814 MIM:603370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GDH; UGD; UDPGDH; UDP-GlcDH
Summary
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Expression
Broad expression in colon (RPKM 31.0), liver (RPKM 26.9) and 23 other tissues See more
Orthologs

Genomic context

See UGDH in Genome Data Viewer
Location:
4p14
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (39498755..39527598, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (39500375..39529218, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene lipoic acid synthetase Neighboring gene WD repeat domain 5 pseudogene Neighboring gene HNF1 and NFE2L2 motif-containing MPRA enhancers 6 and 8 Neighboring gene UGDH antisense RNA 1 Neighboring gene small integral membrane protein 14 Neighboring gene RNA, U7 small nuclear 11 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD binding IEA
Inferred from Electronic Annotation
more info
 
UDP-glucose 6-dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
UDP-glucose 6-dehydrogenase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
UDP-glucuronate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
UDP-glucuronate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
UDP-glucuronate biosynthetic process TAS
Traceable Author Statement
more info
 
chondroitin sulfate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
gastrulation with mouth forming second ISS
Inferred from Sequence or Structural Similarity
more info
 
glycosaminoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparan sulfate proteoglycan biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein hexamerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
UDP-glucose 6-dehydrogenase
Names
UDP-Glc dehydrogenase
UDP-glucose dehydrogenase
uridine diphospho-glucose dehydrogenase
NP_001171629.1
NP_001171630.1
NP_003350.1
XP_005262724.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184700.1NP_001171629.1  UDP-glucose 6-dehydrogenase isoform 2

    See identical proteins and their annotated locations for NP_001171629.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK097930, AL699883, AL708740, AU131705, BC022781, BG194936
    Consensus CDS
    CCDS54758.1
    UniProtKB/Swiss-Prot
    O60701
    Related
    ENSP00000422909.1, ENST00000501493.6
    Conserved Domains (1) summary
    cl27617
    Location:4397
    UDPG_MGDP_dh; UDP-glucose/GDP-mannose dehydrogenase family, central domain
  2. NM_001184701.1NP_001171630.1  UDP-glucose 6-dehydrogenase isoform 3

    See identical proteins and their annotated locations for NP_001171630.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 3 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC021148, AK297737, AL708740, BC022781
    Consensus CDS
    CCDS54757.1
    UniProtKB/Swiss-Prot
    O60701
    Related
    ENSP00000426560.1, ENST00000507089.5
    Conserved Domains (1) summary
    cl27617
    Location:1367
    UDPG_MGDP_dh; UDP-glucose/GDP-mannose dehydrogenase family, central domain
  3. NM_003359.4NP_003350.1  UDP-glucose 6-dehydrogenase isoform 1

    See identical proteins and their annotated locations for NP_003350.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC021148, AF061016, AJ007702
    Consensus CDS
    CCDS3455.1
    UniProtKB/Swiss-Prot
    O60701
    Related
    ENSP00000319501.6, ENST00000316423.10
    Conserved Domains (1) summary
    PLN02353
    Location:4464
    PLN02353; probable UDP-glucose 6-dehydrogenase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    39498755..39527598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262667.3XP_005262724.1  UDP-glucose 6-dehydrogenase isoform X1

    Conserved Domains (4) summary
    PLN02353
    Location:17477
    PLN02353; probable UDP-glucose 6-dehydrogenase
    pfam00984
    Location:227322
    UDPG_MGDP_dh; UDP-glucose/GDP-mannose dehydrogenase family, central domain
    pfam03720
    Location:345459
    UDPG_MGDP_dh_C; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
    pfam03721
    Location:19204
    UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
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