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C8G complement C8 gamma chain [ Homo sapiens (human) ]

Gene ID: 733, updated on 13-Mar-2020

Summary

Official Symbol
C8Gprovided by HGNC
Official Full Name
complement C8 gamma chainprovided by HGNC
Primary source
HGNC:HGNC:1354
See related
Ensembl:ENSG00000176919 MIM:120930
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C8C
Summary
The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]
Expression
Biased expression in liver (RPKM 36.1), duodenum (RPKM 11.1) and 1 other tissue See more
Orthologs

Genomic context

See C8G in Genome Data Viewer
Location:
9q34.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (136944870..136946981)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139839333..139841426)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene TNF receptor associated factor 2 Neighboring gene microRNA 4479 Neighboring gene F-box and WD repeat domain containing 5 Neighboring gene lipocalin 12 Neighboring gene long intergenic non-protein coding RNA 2692

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142186

Gene Ontology Provided by GOA

Function Evidence Code Pubs
complement binding IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
retinol binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
complement activation, alternative pathway IEA
Inferred from Electronic Annotation
more info
 
complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
cytolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of complement activation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
blood microparticle HDA PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
membrane attack complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
complement component C8 gamma chain
Names
complement component 8, gamma polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029580.1 RefSeqGene

    Range
    4998..6730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1211

mRNA and Protein(s)

  1. NM_000606.3NP_000597.2  complement component C8 gamma chain precursor

    See identical proteins and their annotated locations for NP_000597.2

    Status: REVIEWED

    Source sequence(s)
    BX282392, GD261753, HY027599, X06465
    Consensus CDS
    CCDS7017.1
    UniProtKB/Swiss-Prot
    P07360
    Related
    ENSP00000360697.3, ENST00000371634.7
    Conserved Domains (1) summary
    pfam00061
    Location:48184
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    136944870..136946981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_245338.4 RNA Sequence

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