C8g complement component 8, gamma polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: C8gprovided by MGI
Official Full Name: complement component 8, gamma polypeptideprovided by MGI
Primary source: MGI:MGI:88237
See related: Ensembl:ENSMUSG00000015083 AllianceGenome:MGI:88237
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a secreted protein that is a core component of the complement 8 (C8) complex. C8 is part of the membrane attack complex which participates in the innate immune response against bacterial pathogens. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Expression: Biased expression in liver adult (RPKM 279.9), liver E18 (RPKM 36.0) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 17.31 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25388662..25391919, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25498650..25501777, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A review of the human C8 gamma ortholog.
Title: Human complement protein C8 gamma.
This is a study of the human C8 orthologs. Binding of C8 gamma subunit to C8 beta is dependent on the thrombospondin type 1 module, low-density lipoprotein receptor class A module, and membrane attack complex/perforin domain of C8 beta.
Title: Interaction between the C8 alpha-gamma and C8 beta subunits of human complement C8: role of the C8 beta N-terminal thrombospondin type 1 module and membrane attack complex/perforin domain.
This is a study of the human orthologs of C8 alpha, beta, and gamma. C8 gamma is not required for complement-mediated killing of Gram-negative bacteria.
Title: Role of the human C8 subunits in complement-mediated bacterial killing: evidence that C8 gamma is not essential.
Results describe the crystal structure of the human ortholog C8 alpha MACPF domain disulfide-linked to C8 gamma (alphaMACPF-gamma) at 2.15 A resolution.
Title: Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the C8g gene: The C8g gene is conserved in human, chimpanzee, Rhesus monkey, dog, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 463 organisms have orthologs with human gene C8g
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables complement binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables complement binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables retinol binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in complement activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within complement activation, alternative pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of immune response	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of membrane attack complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement component C8 gamma chain

Names: complement component 8, gamma subunit; novel lipocalin protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271777.1 → NP_001258706.1 complement component C8 gamma chain isoform 2

See identical proteins and their annotated locations for NP_001258706.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK005962, AL732557

Consensus CDS

CCDS71001.1

UniProtKB/TrEMBL

Q9DAC2

Related

ENSMUSP00000015227.4, ENSMUST00000015227.4

Conserved Domains (1) summary

pfam00061
Location:14 → 150

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
NM_027062.3 → NP_081338.1 complement component C8 gamma chain isoform 1 precursor

See identical proteins and their annotated locations for NP_081338.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL732557

Consensus CDS

CCDS15777.1

UniProtKB/Swiss-Prot

Q8VCG4

UniProtKB/TrEMBL

Q9DAC2

Related

ENSMUSP00000041855.5, ENSMUST00000040042.11

Conserved Domains (1) summary

pfam00061
Location:48 → 184

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

25388662..25391919 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239171.4 → XP_011237473.1 complement component C8 gamma chain isoform X1

Conserved Domains (1) summary

cl10502
Location:1 → 115

lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family