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UBE2H ubiquitin conjugating enzyme E2 H [ Homo sapiens (human) ]

Gene ID: 7328, updated on 3-May-2020

Summary

Official Symbol
UBE2Hprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Hprovided by HGNC
Primary source
HGNC:HGNC:12484
See related
Ensembl:ENSG00000186591 MIM:601082
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GID3; UBC8; UBCH; UBCH2; E2-20K
Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in heart (RPKM 38.0), adrenal (RPKM 36.4) and 25 other tissues See more
Orthologs

Genomic context

See UBE2H in Genome Data Viewer
Location:
7q32.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (129830732..129952960, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (129470572..129592800, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene microRNA 183 Neighboring gene microRNA 96 Neighboring gene RNA, 5S ribosomal pseudogene 245 Neighboring gene zinc finger C3HC-type containing 1 Neighboring gene kelch domain containing 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ubiquitin-conjugating enzyme E2H (UBE2H) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 H
Names
(E3-independent) E2 ubiquitin-conjugating enzyme H
E2 ubiquitin-conjugating enzyme H
GID complex subunit 3, UBC8 homolog
ubiquitin carrier protein H
ubiquitin conjugating enzyme E2H
ubiquitin-conjugating enzyme E2-20K
ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)
ubiquitin-conjugating enzyme E2H (homologous to yeast UBC8)
ubiquitin-protein ligase H
NP_001189427.1
NP_003335.1
NP_874356.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202498.2NP_001189427.1  ubiquitin-conjugating enzyme E2 H isoform 3

    See identical proteins and their annotated locations for NP_001189427.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 5' region, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC073320, AC084865, AK026094, BC006277, BI088146
    UniProtKB/Swiss-Prot
    P62256
    Related
    ENSP00000497987.1, ENST00000649897.1
    Conserved Domains (1) summary
    cl00154
    Location:175
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. NM_003344.4NP_003335.1  ubiquitin-conjugating enzyme E2 H isoform 1

    See identical proteins and their annotated locations for NP_003335.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB451490, AC073320, AC084865, AK026094
    Consensus CDS
    CCDS5814.1
    UniProtKB/Swiss-Prot
    P62256
    UniProtKB/TrEMBL
    A4D1L5
    Related
    ENSP00000347836.3, ENST00000355621.8
    Conserved Domains (1) summary
    pfam00179
    Location:31145
    UQ_con; Ubiquitin-conjugating enzyme
  3. NM_182697.3NP_874356.1  ubiquitin-conjugating enzyme E2 H isoform 2

    See identical proteins and their annotated locations for NP_874356.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive in-frame exons in the coding region, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC073320, AC084865, AK026094, AY302138
    Consensus CDS
    CCDS47710.1
    UniProtKB/Swiss-Prot
    P62256
    Related
    ENSP00000419097.2, ENST00000473814.6
    Conserved Domains (1) summary
    smart00212
    Location:22119
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    129830732..129952960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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