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RFX8 regulatory factor X8 [ Homo sapiens (human) ]

Gene ID: 731220, updated on 6-Nov-2022

Summary

Official Symbol
RFX8provided by HGNC
Official Full Name
regulatory factor X8provided by HGNC
Primary source
HGNC:HGNC:37253
See related
Ensembl:ENSG00000196460 AllianceGenome:HGNC:37253
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bone marrow (RPKM 1.7), testis (RPKM 0.8) and 12 other tissues See more
Orthologs
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Genomic context

See RFX8 in Genome Data Viewer
Location:
2q11.2
Exon count:
18
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101397359..101475112, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (101856061..101933799, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102013821..102091574, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:101946330-101947106 and GRCh37_chr2:101947107-101947883 Neighboring gene cellular repressor of E1A stimulated genes 2 Neighboring gene succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like Neighboring gene long intergenic non-protein coding RNA 1870 Neighboring gene ribosomal protein S6 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16242, FLJ42986, FLJ52890

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA-binding protein RFX8
Names
RFX family member 8, lacking RFX DNA binding domain
regulatory factor X, 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145664.2NP_001139136.2  DNA-binding protein RFX8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC092570
    Consensus CDS
    CCDS46376.1
    Related
    ENSP00000401536.1, ENST00000428343.6
    Conserved Domains (1) summary
    pfam02257
    Location:125
    RFX_DNA_binding; RFX DNA-binding domain
  2. NM_001367508.1NP_001354437.1  DNA-binding protein RFX8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092570
  3. NM_001367509.1NP_001354438.1  DNA-binding protein RFX8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092570
  4. NM_001367510.1NP_001354439.1  DNA-binding protein RFX8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092570

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    101397359..101475112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511771.3XP_011510073.1  DNA-binding protein RFX8 isoform X2

  2. XM_047445739.1XP_047301695.1  DNA-binding protein RFX8 isoform X3

    UniProtKB/TrEMBL
    A0A2R8Y560
    Related
    ENSP00000494216.1, ENST00000646446.1
  3. XM_017004852.2XP_016860341.1  DNA-binding protein RFX8 isoform X4

    UniProtKB/TrEMBL
    A0A2R8YED2
  4. XM_017004851.2XP_016860340.1  DNA-binding protein RFX8 isoform X1

    UniProtKB/Swiss-Prot
    B4DQ32, Q6ZV50
    Related
    ENSP00000494249.2, ENST00000646893.2
    Conserved Domains (1) summary
    pfam02257
    Location:2395
    RFX_DNA_binding; RFX DNA-binding domain
  5. XM_047445740.1XP_047301696.1  DNA-binding protein RFX8 isoform X6

  6. XM_011511773.2XP_011510075.1  DNA-binding protein RFX8 isoform X5

  7. XM_047445741.1XP_047301697.1  DNA-binding protein RFX8 isoform X8

  8. XM_011511778.2XP_011510080.1  DNA-binding protein RFX8 isoform X8

    See identical proteins and their annotated locations for XP_011510080.1

  9. XM_011511777.3XP_011510079.1  DNA-binding protein RFX8 isoform X8

    See identical proteins and their annotated locations for XP_011510079.1

  10. XM_017004854.1XP_016860343.1  DNA-binding protein RFX8 isoform X7

  11. XM_047445742.1XP_047301698.1  DNA-binding protein RFX8 isoform X9

  12. XM_047445743.1XP_047301699.1  DNA-binding protein RFX8 isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    101856061..101933799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207403.1: Suppressed sequence

    Description
    NM_207403.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein is not supported by current protein homology data.