Format

Send to:

Choose Destination

RFX8 regulatory factor X8 [ Homo sapiens (human) ]

Gene ID: 731220, updated on 25-Jan-2022

Summary

Official Symbol
RFX8provided by HGNC
Official Full Name
regulatory factor X8provided by HGNC
Primary source
HGNC:HGNC:37253
See related
Ensembl:ENSG00000196460 AllianceGenome:HGNC:37253
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in bone marrow (RPKM 1.7), testis (RPKM 0.8) and 12 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See RFX8 in Genome Data Viewer
Location:
2q11.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (101397344..101475179, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102013821..102091574, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6404 Neighboring gene cellular repressor of E1A stimulated genes 2 Neighboring gene succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial pseudogene Neighboring gene long intergenic non-protein coding RNA 1870 Neighboring gene ribosomal protein S6 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ16242, FLJ42986, FLJ52890

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA-binding protein RFX8
Names
RFX family member 8, lacking RFX DNA binding domain
regulatory factor X, 8

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145664.2NP_001139136.2  DNA-binding protein RFX8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC092570
    Consensus CDS
    CCDS46376.1
    Related
    ENSP00000401536.1, ENST00000428343.6
    Conserved Domains (1) summary
    pfam02257
    Location:125
    RFX_DNA_binding; RFX DNA-binding domain
  2. NM_001367508.1NP_001354437.1  DNA-binding protein RFX8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092570
  3. NM_001367509.1NP_001354438.1  DNA-binding protein RFX8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092570
  4. NM_001367510.1NP_001354439.1  DNA-binding protein RFX8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092570

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    101397344..101475179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511771.2XP_011510073.1  DNA-binding protein RFX8 isoform X2

  2. XM_011511772.1XP_011510074.1  DNA-binding protein RFX8 isoform X3

    Related
    ENSP00000494216.1, ENST00000646446.1
    Conserved Domains (1) summary
    pfam02257
    Location:153
    RFX_DNA_binding; RFX DNA-binding domain
  3. XM_017004852.1XP_016860341.1  DNA-binding protein RFX8 isoform X4

    Related
    ENSP00000494249.1, ENST00000646893.1
  4. XM_017004851.1XP_016860340.1  DNA-binding protein RFX8 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZV50
    Conserved Domains (1) summary
    pfam02257
    Location:2395
    RFX_DNA_binding; RFX DNA-binding domain
  5. XM_011511776.1XP_011510078.1  DNA-binding protein RFX8 isoform X8

    See identical proteins and their annotated locations for XP_011510078.1

  6. XM_011511773.1XP_011510075.1  DNA-binding protein RFX8 isoform X5

  7. XM_011511777.2XP_011510079.1  DNA-binding protein RFX8 isoform X8

    See identical proteins and their annotated locations for XP_011510079.1

  8. XM_011511778.1XP_011510080.1  DNA-binding protein RFX8 isoform X8

    See identical proteins and their annotated locations for XP_011510080.1

  9. XM_017004853.1XP_016860342.1  DNA-binding protein RFX8 isoform X6

  10. XM_017004854.1XP_016860343.1  DNA-binding protein RFX8 isoform X7

RNA

  1. XR_001738924.1 RNA Sequence

    Related
    ENST00000481179.5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207403.1: Suppressed sequence

    Description
    NM_207403.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein is not supported by current protein homology data.
Support Center