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Rfx8 regulatory factor X 8 [ Mus musculus (house mouse) ]

Gene ID: 619289, updated on 12-May-2024

Summary

Official Symbol
Rfx8provided by MGI
Official Full Name
regulatory factor X 8provided by MGI
Primary source
MGI:MGI:3588206
See related
Ensembl:ENSMUSG00000057173 AllianceGenome:MGI:3588206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933400N17Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in testis. Orthologous to human RFX8 (regulatory factor X8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 12.4) See more
Orthologs
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Genomic context

See Rfx8 in Genome Data Viewer
Location:
1 B; 1 18.41 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (39704459..39760149, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (39665299..39720989, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cellular repressor of E1A-stimulated genes 2 Neighboring gene RIKEN cDNA D930019O06 Neighboring gene STARR-seq mESC enhancer starr_00725 Neighboring gene STARR-seq mESC enhancer starr_00727 Neighboring gene STARR-positive B cell enhancer ABC_E9462 Neighboring gene STARR-seq mESC enhancer starr_00729 Neighboring gene predicted gene 3646 Neighboring gene RIKEN cDNA 1700066B17 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145660.1NP_001139132.1  DNA-binding protein RFX8

    See identical proteins and their annotated locations for NP_001139132.1

    Status: VALIDATED

    Source sequence(s)
    AC122922, AK133372, BG808411
    Consensus CDS
    CCDS48245.1
    UniProtKB/Swiss-Prot
    D3YU81
    Related
    ENSMUSP00000121212.2, ENSMUST00000151913.3
    Conserved Domains (1) summary
    pfam02257
    Location:1990
    RFX_DNA_binding; RFX DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    39704459..39760149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238564.4XP_011236866.1  DNA-binding protein RFX8 isoform X1