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Emc7 ER membrane protein complex subunit 7 [ Mus musculus (house mouse) ]

Gene ID: 73024, updated on 20-Apr-2024

Summary

Official Symbol
Emc7provided by MGI
Official Full Name
ER membrane protein complex subunit 7provided by MGI
Primary source
MGI:MGI:1920274
See related
Ensembl:ENSMUSG00000055943 AllianceGenome:MGI:1920274
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ORF3; c11orf3; 2900064A13Rik
Summary
Predicted to enable carbohydrate binding activity. Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be part of EMC complex. Is expressed in central nervous system; liver; lung; retina nuclear layer; and skeletal muscle. Orthologous to human EMC7 (ER membrane protein complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 15.8), placenta adult (RPKM 15.4) and 28 other tissues See more
Orthologs
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Genomic context

See Emc7 in Genome Data Viewer
Location:
2 E3; 2 57.02 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (112285332..112302507)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (112455014..112472163)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 12, member 6 Neighboring gene STARR-positive B cell enhancer mm9_chr2:112219168-112219469 Neighboring gene STARR-positive B cell enhancer ABC_E5959 Neighboring gene katanin p80 subunit B like 1 Neighboring gene STARR-positive B cell enhancer ABC_E3389 Neighboring gene STARR-positive B cell enhancer ABC_E11150 Neighboring gene ER membrane protein complex subunit 4 Neighboring gene STARR-positive B cell enhancer ABC_E4487 Neighboring gene STARR-seq mESC enhancer starr_05388 Neighboring gene cholinergic receptor, muscarinic 5 Neighboring gene predicted gene, 22676 Neighboring gene apoptosis, caspase activation inhibitor Neighboring gene STARR-positive B cell enhancer mm9_chr2:112443695-112443995 Neighboring gene STARR-seq mESC enhancer starr_05389 Neighboring gene STARR-seq mESC enhancer starr_05390 Neighboring gene ryanodine receptor 3 Neighboring gene STARR-seq mESC enhancer starr_05392 Neighboring gene STARR-seq mESC enhancer starr_05393 Neighboring gene STARR-seq mESC enhancer starr_05394

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC144286, MGC144287

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to membrane insertase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of EMC complex ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
endoplasmic reticulum membrane protein complex subunit 7; ER membrane protein complex subunit 7
Names
UPF0480 protein C15orf24 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133749.2NP_598510.1  endoplasmic reticulum membrane protein complex subunit 7 precursor

    See identical proteins and their annotated locations for NP_598510.1

    Status: PROVISIONAL

    Source sequence(s)
    AL683897, AL731840
    Consensus CDS
    CCDS16555.1
    UniProtKB/Swiss-Prot
    Q9EP72
    UniProtKB/TrEMBL
    Q14C26
    Related
    ENSMUSP00000068610.6, ENSMUST00000069747.6
    Conserved Domains (1) summary
    pfam09430
    Location:56167
    DUF2012; Protein of unknown function (DUF2012)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    112285332..112302507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500254.5XP_006500317.1  ER membrane protein complex subunit 7 isoform X1

    See identical proteins and their annotated locations for XP_006500317.1

    Conserved Domains (1) summary
    pfam09430
    Location:695
    DUF2012; Protein of unknown function (DUF2012)