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EMC7 ER membrane protein complex subunit 7 [ Homo sapiens (human) ]

Gene ID: 56851, updated on 22-Sep-2022

Summary

Official Symbol
EMC7provided by HGNC
Official Full Name
ER membrane protein complex subunit 7provided by HGNC
Primary source
HGNC:HGNC:24301
See related
Ensembl:ENSG00000134153 AllianceGenome:HGNC:24301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HT022; C11orf3; C15orf24; ORF1-FL1
Summary
Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Is integral component of endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 46.7), adrenal (RPKM 45.9) and 25 other tissues See more
Orthologs
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Genomic context

See EMC7 in Genome Data Viewer
Location:
15q14
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (34084017..34101862, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (31882200..31900068, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34376218..34394063, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ryanodine receptor 3 Neighboring gene complement C1q binding protein pseudogene 3 Neighboring gene apoptosis and caspase activation inhibitor Neighboring gene cholinergic receptor muscarinic 5 Neighboring gene ribosomal protein L32 pseudogene 2 Neighboring gene piggyBac transposable element derived 4 Neighboring gene katanin regulatory subunit B1 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to membrane insertase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of EMC complex IC
Inferred by Curator
more info
 
part_of EMC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of EMC complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ER membrane protein complex subunit 7
Names
UPF0480 protein C15orf24
chromosome 15 hypothetical ATG/GTP binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020154.3NP_064539.1  ER membrane protein complex subunit 7 precursor

    See identical proteins and their annotated locations for NP_064539.1

    Status: VALIDATED

    Source sequence(s)
    AC069045, AC079203, AJ245874, BC012456
    Consensus CDS
    CCDS10032.1
    UniProtKB/Swiss-Prot
    Q96ED5, Q9NPA0
    Related
    ENSP00000256545.4, ENST00000256545.9
    Conserved Domains (1) summary
    pfam09430
    Location:57168
    DUF2012; Protein of unknown function (DUF2012)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    34084017..34101862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    31882200..31900068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)