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RAD51AP2 RAD51 associated protein 2 [ Homo sapiens (human) ]

Gene ID: 729475, updated on 3-Nov-2024

Summary

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Official Symbol
RAD51AP2provided by HGNC
Official Full Name
RAD51 associated protein 2provided by HGNC
Primary source
HGNC:HGNC:34417
See related
Ensembl:ENSG00000214842 AllianceGenome:HGNC:34417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Part of protein-containing complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis (RPKM 5.9) See more
Orthologs
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Genomic context

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See RAD51AP2 in Genome Data Viewer
Location:
2p24.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (17510579..17537859, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (17542340..17569626, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (17691846..17711681, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373447 Neighboring gene proteasome 26S subunit, ATPase 1 pseudogene 10 Neighboring gene uncharacterized LOC105373448 Neighboring gene nascent polypeptide associated complex subunit alpha pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:17699235-17700434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15351 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:17724689-17725200 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:17725201-17725712 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:17760843-17761612 Neighboring gene visinin like 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:17771124-17772061 Neighboring gene uncharacterized LOC124908054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:17825464-17826251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15352 Neighboring gene structural maintenance of chromosomes 6 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:17929152-17929835 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11190 Neighboring gene GEN1 Holliday junction 5' flap endonuclease

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51. Kovalenko OV, et al. Nucleic Acids Res, 2006. PMID 16990250, Free PMC Article
  2. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. Fox CS, et al. PLoS Genet, 2012. PMID 22589738, Free PMC Article
  3. Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013
  4. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Dendoncker K, et al. Proc Natl Acad Sci U S A, 2019 Jun 25. PMID 31182584, Free PMC Article
  5. DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples. Jiao F, et al. J Proteome Res, 2024 Aug 2. PMID 38334954, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel protein, RAD51AP2, has been discovered that interacts with RAD51 through a C-terminal motif also present in RAD51AP1.
    Title: RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
RAD51-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099218.3 → NP_001092688.1  RAD51-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001092688.1

    Status: VALIDATED

    Source sequence(s)
    AC104812, DQ860102
    Consensus CDS
    CCDS42656.1
    UniProtKB/Swiss-Prot
    Q09MP3
    Related
    ENSP00000382030.2, ENST00000399080.3
    Conserved Domains (1) summary
    pfam15696
    Location:1109 → 1147
    RAD51_interact; RAD51 interacting motif

  2. NM_001321233.1 → NP_001308162.1  RAD51-associated protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104812, AK310498, BG216055
    Conserved Domains (1) summary
    pfam15696
    Location:1100 → 1138
    RAD51_interact; RAD51 interacting motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    17510579..17537859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453116.2 → XP_024308884.1  RAD51-associated protein 2 isoform X1

    Conserved Domains (1) summary
    pfam15696
    Location:1100 → 1138
    RAD51_interact; RAD51 interacting motif

  2. XM_024453117.2 → XP_024308885.1  RAD51-associated protein 2 isoform X1

    Conserved Domains (1) summary
    pfam15696
    Location:1100 → 1138
    RAD51_interact; RAD51 interacting motif

  3. XM_047445730.1 → XP_047301686.1  RAD51-associated protein 2 isoform X1

  4. XM_011533084.3 → XP_011531386.1  RAD51-associated protein 2 isoform X2

    Conserved Domains (1) summary
    pfam15696
    Location:1082 → 1120
    RAD51_interact; RAD51 interacting motif

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    17542340..17569626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343723.1 → XP_054199698.1  RAD51-associated protein 2 isoform X1

  2. XM_054343724.1 → XP_054199699.1  RAD51-associated protein 2 isoform X1

  3. XM_054343725.1 → XP_054199700.1  RAD51-associated protein 2 isoform X1

  4. XM_054343726.1 → XP_054199701.1  RAD51-associated protein 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09MP3.1 GenPept UniProtKB/Swiss-Prot:Q09MP3

Gene LinkOut

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