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RAD51AP2 RAD51 associated protein 2 [ Homo sapiens (human) ]

Gene ID: 729475, updated on 8-Dec-2022

Summary

Official Symbol
RAD51AP2provided by HGNC
Official Full Name
RAD51 associated protein 2provided by HGNC
Primary source
HGNC:HGNC:34417
See related
Ensembl:ENSG00000214842 AllianceGenome:HGNC:34417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable double-stranded DNA binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination and interstrand cross-link repair. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 5.9) See more
Orthologs
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Genomic context

See RAD51AP2 in Genome Data Viewer
Location:
2p24.2
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (17510579..17537859, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (17542340..17562183, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (17691846..17711681, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373447 Neighboring gene proteasome 26S subunit, ATPase 1 pseudogene 10 Neighboring gene uncharacterized LOC105373448 Neighboring gene nascent polypeptide associated complex subunit alpha pseudogene Neighboring gene visinin like 1 Neighboring gene uncharacterized LOC124908054 Neighboring gene structural maintenance of chromosomes 6 Neighboring gene GEN1 Holliday junction 5' flap endonuclease

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099218.3NP_001092688.1  RAD51-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001092688.1

    Status: VALIDATED

    Source sequence(s)
    AC104812, DQ860102
    Consensus CDS
    CCDS42656.1
    UniProtKB/Swiss-Prot
    Q09MP3
    Related
    ENSP00000382030.2, ENST00000399080.3
    Conserved Domains (1) summary
    pfam15696
    Location:11091147
    RAD51_interact; RAD51 interacting motif
  2. NM_001321233.1NP_001308162.1  RAD51-associated protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104812, AK310498, BG216055
    Conserved Domains (1) summary
    pfam15696
    Location:11001138
    RAD51_interact; RAD51 interacting motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    17510579..17537859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453116.2XP_024308884.1  RAD51-associated protein 2 isoform X1

    Conserved Domains (1) summary
    pfam15696
    Location:11001138
    RAD51_interact; RAD51 interacting motif
  2. XM_024453117.2XP_024308885.1  RAD51-associated protein 2 isoform X1

    Conserved Domains (1) summary
    pfam15696
    Location:11001138
    RAD51_interact; RAD51 interacting motif
  3. XM_047445730.1XP_047301686.1  RAD51-associated protein 2 isoform X1

  4. XM_011533084.3XP_011531386.1  RAD51-associated protein 2 isoform X2

    Conserved Domains (1) summary
    pfam15696
    Location:10821120
    RAD51_interact; RAD51 interacting motif

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    17542340..17562183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)