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C12orf73 chromosome 12 open reading frame 73 [ Homo sapiens (human) ]

Gene ID: 728568, updated on 23-Nov-2021

Summary

Official Symbol
C12orf73provided by HGNC
Official Full Name
chromosome 12 open reading frame 73provided by HGNC
Primary source
HGNC:HGNC:34450
See related
Ensembl:ENSG00000204954 MIM:618812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BR; BRAWNIN
Expression
Ubiquitous expression in thyroid (RPKM 2.9), brain (RPKM 1.8) and 25 other tissues See more
Orthologs
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Genomic context

See C12orf73 in Genome Data Viewer
Location:
12q23.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (103950194..103965755, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (104343972..104350993, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 41, pseudogene Neighboring gene uncharacterized LOC107984130 Neighboring gene heat shock protein 90 beta family member 1 Neighboring gene microRNA 3652 Neighboring gene thymine DNA glycosylase Neighboring gene glycosyltransferase 8 domain containing 2 Neighboring gene phosphoglycerate mutase 1 (brain) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13975, DKFZp547P055

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex III assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial respiratory chain complex III assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein BRAWNIN
Names
uncharacterized protein C12orf73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135570.3NP_001129042.1  protein BRAWNIN precursor

    See identical proteins and their annotated locations for NP_001129042.1

    Status: VALIDATED

    Source sequence(s)
    AC078819
    Consensus CDS
    CCDS44964.1
    UniProtKB/Swiss-Prot
    Q69YU5
    Related
    ENSP00000367330.4, ENST00000378090.9
    Conserved Domains (1) summary
    pfam14990
    Location:146
    DUF4516; Domain of unknown function (DUF4516)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    103950194..103965755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538718.3XP_011537020.1  protein BRAWNIN isoform X1

  2. XM_017019916.2XP_016875405.1  protein BRAWNIN isoform X2

    UniProtKB/Swiss-Prot
    Q69YU5
    Related
    ENSP00000449839.1, ENST00000547945.5
    Conserved Domains (1) summary
    pfam14990
    Location:146
    DUF4516; Domain of unknown function (DUF4516)
  3. XM_017019917.2XP_016875406.1  protein BRAWNIN isoform X2

    UniProtKB/Swiss-Prot
    Q69YU5
    Related
    ENSP00000446981.1, ENST00000553183.5
    Conserved Domains (1) summary
    pfam14990
    Location:146
    DUF4516; Domain of unknown function (DUF4516)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_024026.1: Suppressed sequence

    Description
    NR_024026.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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