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Mon1a MON1 homolog A, secretory traffciking associated [ Mus musculus (house mouse) ]

Gene ID: 72825, updated on 30-Apr-2024

Summary

Official Symbol
Mon1aprovided by MGI
Official Full Name
MON1 homolog A, secretory traffciking associatedprovided by MGI
Primary source
MGI:MGI:1920075
See related
Ensembl:ENSMUSG00000032583 AllianceGenome:MGI:1920075
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810468K17Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within cellular iron ion homeostasis and protein secretion. Predicted to be part of Mon1-Ccz1 complex. Orthologous to human MON1A (MON1 homolog A, secretory trafficking associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 31.1), small intestine adult (RPKM 27.7) and 28 other tissues See more
Orthologs
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Genomic context

See Mon1a in Genome Data Viewer
Location:
9 F1; 9 59.07 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107765282..107780338)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107888083..107903139)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 5 Neighboring gene STARR-seq mESC enhancer starr_25188 Neighboring gene RNA binding motif protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E6802 Neighboring gene predicted gene, 23856 Neighboring gene macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein targeting to vacuole IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Mon1-Ccz1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Mon1-Ccz1 complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
vacuolar fusion protein MON1 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028369.3NP_082645.1  vacuolar fusion protein MON1 homolog A

    See identical proteins and their annotated locations for NP_082645.1

    Status: VALIDATED

    Source sequence(s)
    AK013387, AW045198, BY064239
    Consensus CDS
    CCDS23508.1
    UniProtKB/TrEMBL
    A0A0R4J0D5, A0A0R4J2D4
    Related
    ENSMUSP00000035202.3, ENSMUST00000035202.4
    Conserved Domains (1) summary
    pfam03164
    Location:155555
    Mon1; Trafficking protein Mon1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107765282..107780338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313611.2XP_017169100.1  vacuolar fusion protein MON1 homolog A isoform X1

    Conserved Domains (1) summary
    pfam03164
    Location:32345
    Mon1; Trafficking protein Mon1

RNA

  1. XR_001779021.2 RNA Sequence