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RNF208 ring finger protein 208 [ Homo sapiens (human) ]

Gene ID: 727800, updated on 26-Oct-2022

Summary

Official Symbol
RNF208provided by HGNC
Official Full Name
ring finger protein 208provided by HGNC
Primary source
HGNC:HGNC:25420
See related
Ensembl:ENSG00000212864 MIM:618993; AllianceGenome:HGNC:25420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables ubiquitin-protein transferase activity. Involved in protein autoubiquitination. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See RNF208 in Genome Data Viewer
Location:
9q34.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (137220259..137223408, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (149457928..149461077, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140114711..140117860, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 203 Neighboring gene NADPH dependent diflavin oxidoreductase 1 Neighboring gene ring finger protein-like Neighboring gene cysteine rich tail 1 Neighboring gene hESC enhancers GRCh37_chr9:140121623-140122123 and GRCh37_chr9:140122257-140122882 Neighboring gene ring finger protein 224

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC88636, DKFZp761H1710

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001388297.1NP_001375226.1  RING finger protein 208 isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX255925
    Consensus CDS
    CCDS7037.2
    UniProtKB/Swiss-Prot
    A2BFA0
    Conserved Domains (1) summary
    cd16559
    Location:140193
    RING-HC_RNF208; RING finger, HC subclass, found in RING finger protein 208 (RNF208) and similar proteins
  2. NM_001388298.1NP_001375227.1  RING finger protein 208 isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX255925
    Consensus CDS
    CCDS7037.2
    UniProtKB/Swiss-Prot
    A2BFA0
    Conserved Domains (1) summary
    cd16559
    Location:140193
    RING-HC_RNF208; RING finger, HC subclass, found in RING finger protein 208 (RNF208) and similar proteins
  3. NM_031297.7NP_112587.2  RING finger protein 208 isoform 1

    See identical proteins and their annotated locations for NP_112587.2

    Status: VALIDATED

    Source sequence(s)
    BX255925
    Consensus CDS
    CCDS7037.2
    UniProtKB/Swiss-Prot
    A2BFA0, Q9H0X6
    Related
    ENSP00000375397.1, ENST00000391553.3
    Conserved Domains (1) summary
    cd16559
    Location:140193
    RING-HC_RNF208; RING finger, HC subclass, found in RING finger protein 208 (RNF208) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    137220259..137223408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    149457928..149461077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)