Sign in to NCBI
Format

Send to:

Choose Destination

Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 72508, updated on 5-Jan-2021

Summary

Go to the top of the page Help
Official Symbol
Rps6kb1provided by MGI
Official Full Name
ribosomal protein S6 kinase, polypeptide 1provided by MGI
Primary source
MGI:MGI:1270849
See related
Ensembl:ENSMUSG00000020516
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S6K; S6K1; p70s; p70S6; p70s6k; P70S6K1; p70/85s; AA959758; AI256796; AI314060; p70 S6KA; p70-S6K 1; p70/85s6k; S6K-beta-1; 2610318I15Rik; p70 S6K-alpha
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.0), limb E14.5 (RPKM 4.8) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Data Table view

Genomic context

Go to the top of the page Help
See Rps6kb1 in Genome Data Viewer
Location:
11; 11 C
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86389695..86435711, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86498869..86544885, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (86312511..86358309, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 185 pseudogene Neighboring gene predicted gene, 26439 Neighboring gene ring finger protein, transmembrane 1 Neighboring gene tubulin, delta 1 Neighboring gene microRNA 21a Neighboring gene vacuole membrane protein 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Deficiency of the oxidative stress-responsive kinase p70S6K1 restores autophagy and ameliorates neural tube defects in diabetic embryopathy. Cao S, et al. Am J Obstet Gynecol, 2020 Nov. PMID 32416155,
  2. Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington's disease. Irvine EE, et al. Sci Rep, 2019 Nov 6. PMID 31695068, Free PMC Article
  3. S6 kinase 1 plays a key role in mitochondrial morphology and cellular energy flow. Tran Q, et al. Cell Signal, 2018 Aug. PMID 29673648
  4. S6K1 controls epigenetic plasticity for the expression of pancreatic α/β cell marker genes. Yi SA, et al. J Cell Biochem, 2018 Aug. PMID 29665055
  5. Absence of the kinase S6k1 mimics the effect of chronic endurance exercise on glucose tolerance and muscle oxidative stress. Binsch C, et al. Mol Metab, 2017 Nov. PMID 29107291, Free PMC Article

See all (257) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency of the oxidative stress-responsive kinase p70S6K1 restores autophagy and ameliorates neural tube defects in diabetic embryopathy.
    Title: Deficiency of the oxidative stress-responsive kinase p70S6K1 restores autophagy and ameliorates neural tube defects in diabetic embryopathy.
  2. Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington's disease.
    Title: Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington's disease.
  3. OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance.
    Title: OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance.
  4. Our data demonstrated that S6K1 was the downstream effector of mTOR and that S6K1 was critical for both rod and cone survival in Retinitis pigmentosa (RP). Our findings make a strong case for targeting S6K1 as a promising therapeutic strategy for promoting the survival of photoreceptors in RP
    Title: Ribosomal protein S6 kinase 1 promotes the survival of photoreceptors in retinitis pigmentosa.
  5. these results have suggested a potential role of S6K1 in energy metabolism by modulating mitochondrial respiratory capacity and mitochondrial morphology.
    Title: S6 kinase 1 plays a key role in mitochondrial morphology and cellular energy flow.
  6. Embedded within S6K1 is a target-selective kinase phospho-code that integrates signals from mTORC1 and Cdk5 to direct an insulin-stimulated, post-translational metabolon determining adipocyte lipid metabolism.
    Title: Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection.
  7. These results suggest that S6K1 drives the alpha to beta transition through the epigenetic regulation of cell-specific genes, including insulin and glucagon. This novel role of S6K1 in islet cells provides basic clues to establish therapeutic strategies against T1DM.
    Title: S6K1 controls epigenetic plasticity for the expression of pancreatic α/β cell marker genes.
  8. The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168 in embryonic fibroblasts.
    Title: The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168.
  9. In high-fat fed mice, loss of S6K1 mimics endurance exercise training by reducing mitochondrial ROS production and upregulating oxidative utilization of ketone bodies.
    Title: Absence of the kinase S6k1 mimics the effect of chronic endurance exercise on glucose tolerance and muscle oxidative stress.
  10. DPP-4 inhibitor sitagliptin has effects on cardiac function, glycemia, and beta-cell function together with reducing S6K1 activation and IRS-1 and IRS-2 degradation in the obesity female mouse model
    Title: DPP-4 Inhibitor Sitagliptin Improves Cardiac Function and Glucose Homeostasis and Ameliorates <i>β</i>-Cell Dysfunction Together with Reducing S6K1 Activation and IRS-1 and IRS-2 Degradation in Obesity Female Mice.
Submit: New GeneRIF Correction See all GeneRIFs (129)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • 4732464A07Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
  
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
identical protein binding ISO
Inferred from Sequence Orthology
more info
  
kinase activity IEA
Inferred from Electronic Annotation
more info
  
nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
peptide binding ISO
Inferred from Sequence Orthology
more info
  
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
  
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
ribosomal protein S6 kinase activity ISO
Inferred from Sequence Orthology
more info
  
transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
TOR signaling ISO
Inferred from Sequence Orthology
more info
  
apoptotic process IEA
Inferred from Electronic Annotation
more info
  
behavioral fear response IGI
Inferred from Genetic Interaction
more info
 PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
  
cellular response to dexamethasone stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
cellular response to interferon-gamma IMP
Inferred from Mutant Phenotype
more info
 PubMed 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
 PubMed 
germ cell development IDA
Inferred from Direct Assay
more info
 PubMed 
long-chain fatty acid import into cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
phosphorylation IEA
Inferred from Electronic Annotation
more info
  
positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
positive regulation of skeletal muscle tissue growth ISO
Inferred from Sequence Orthology
more info
  
positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
  
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
positive regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
regulation of glucose import ISO
Inferred from Sequence Orthology
more info
  
regulation of translation IEA
Inferred from Electronic Annotation
more info
  
response to insulin ISO
Inferred from Sequence Orthology
more info
  
response to nutrient levels ISO
Inferred from Sequence Orthology
more info
  
response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
  
cell surface ISO
Inferred from Sequence Orthology
more info
  
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
  
cytosol ISO
Inferred from Sequence Orthology
more info
  
membrane IEA
Inferred from Electronic Annotation
more info
  
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
  
neuron projection IEA
Inferred from Electronic Annotation
more info
  
nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
  
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ribosomal protein S6 kinase beta-1
Names
70 kDa ribosomal protein S6 kinase 1
p70 S6 kinase alpha
p70 ribosomal S6 kinase alpha
ribosomal protein S6 kinase I
ribosomal protein S6 kinase, 70kD, polypeptide 1
NP_001107806.1
NP_001350091.1
NP_082535.1
XP_006534378.1
XP_011247577.1
XP_011247578.1
XP_036012907.1
XP_036012908.1
XP_036012909.1
XP_036012910.1
XP_036012911.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Data Table view

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114334.2 → NP_001107806.1  ribosomal protein S6 kinase beta-1 isoform 1

    See identical proteins and their annotated locations for NP_001107806.1

    Status: VALIDATED

    Source sequence(s)
    AK032724, AK135716, AL604063
    Consensus CDS
    CCDS48875.1
    UniProtKB/Swiss-Prot
    Q8BSK8
    UniProtKB/TrEMBL
    Q3UXD8
    Related
    ENSMUSP00000119715.1, ENSMUST00000154617.7
    Conserved Domains (1) summary
    cd05584
    Location:94 → 416
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  2. NM_001363162.1 → NP_001350091.1  ribosomal protein S6 kinase beta-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL604063
    Conserved Domains (1) summary
    cd05584
    Location:41 → 363
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  3. NM_028259.4 → NP_082535.1  ribosomal protein S6 kinase beta-1 isoform 2

    See identical proteins and their annotated locations for NP_082535.1

    Status: VALIDATED

    Source sequence(s)
    AL604063
    Consensus CDS
    CCDS25201.1
    UniProtKB/TrEMBL
    Q8C3J7
    Related
    ENSMUSP00000053188.2, ENSMUST00000058286.8
    Conserved Domains (1) summary
    cl21453
    Location:94 → 195
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    86389695..86435711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157018.1 → XP_036012911.1  ribosomal protein S6 kinase beta-1 isoform X5

  2. XM_036157014.1 → XP_036012907.1  ribosomal protein S6 kinase beta-1 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 213
    PKc_like; Protein Kinases, catalytic domain

  3. XM_036157016.1 → XP_036012909.1  ribosomal protein S6 kinase beta-1 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 213
    PKc_like; Protein Kinases, catalytic domain

  4. XM_036157017.1 → XP_036012910.1  ribosomal protein S6 kinase beta-1 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 213
    PKc_like; Protein Kinases, catalytic domain

  5. XM_036157015.1 → XP_036012908.1  ribosomal protein S6 kinase beta-1 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 213
    PKc_like; Protein Kinases, catalytic domain

  6. XM_011249275.4 → XP_011247577.1  ribosomal protein S6 kinase beta-1 isoform X1

    Conserved Domains (1) summary
    cd05584
    Location:94 → 416
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  7. XM_006534315.5 → XP_006534378.1  ribosomal protein S6 kinase beta-1 isoform X2

    Conserved Domains (1) summary
    cd05584
    Location:48 → 336
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  8. XM_011249276.4 → XP_011247578.1  ribosomal protein S6 kinase beta-1 isoform X3

    Conserved Domains (1) summary
    cd05584
    Location:94 → 409
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

RNA

  1. XR_004937046.1 RNA Sequence

  2. XR_004937048.1 RNA Sequence

  3. XR_004937047.1 RNA Sequence

  4. XR_001780060.3 RNA Sequence

  5. XR_003949511.2 RNA Sequence

  6. XR_003949513.1 RNA Sequence

  7. XR_879743.4 RNA Sequence

  8. XR_004937043.1 RNA Sequence

  9. XR_004937042.1 RNA Sequence

  10. XR_004937044.1 RNA Sequence

  11. XR_004937045.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BSK8.2 GenPept UniProtKB/Swiss-Prot:Q8BSK8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous
You are here: NCBI > Genes & Expression > Gene
Support Center