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Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 72508, updated on 9-Aug-2022

Summary

Official Symbol
Rps6kb1provided by MGI
Official Full Name
ribosomal protein S6 kinase, polypeptide 1provided by MGI
Primary source
MGI:MGI:1270849
See related
Ensembl:ENSMUSG00000020516 AllianceGenome:MGI:1270849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S6K; S6K1; p70s6k; P70S6K1; AA959758; AI256796; AI314060; p70 S6KA; p70-S6K 1; p70/85s6k; S6K-beta-1; 2610318I15Rik; p70 S6K-alpha
Summary
Enables protein kinase activity. Involved in several processes, including cellular response to interferon-gamma; long-chain fatty acid import into cell; and peptidyl-serine phosphorylation. Acts upstream of or within several processes, including behavioral fear response; cellular response to hormone stimulus; and protein kinase B signaling. Located in mitochondrion. Is expressed in several structures, including central nervous system; early conceptus; olfactory epithelium; reproductive system; and retina nuclear layer. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.0), limb E14.5 (RPKM 4.8) and 26 other tissues See more
Orthologs
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Genomic context

See Rps6kb1 in Genome Data Viewer
Location:
11; 11 C
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86389695..86435711, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86498869..86544885, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (86312511..86358309, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 185 pseudogene Neighboring gene predicted gene, 26439 Neighboring gene ring finger protein, transmembrane 1 Neighboring gene tubulin, delta 1 Neighboring gene microRNA 21a Neighboring gene vacuole membrane protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • 4732464A07Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribosomal protein S6 kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in TOR signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within TORC1 signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within behavioral fear response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to dexamethasone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to interferon-gamma IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within germ cell development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid import into cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of skeletal muscle tissue growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nutrient levels ISO
Inferred from Sequence Orthology
more info
 
involved_in response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ribosomal protein S6 kinase beta-1
Names
70 kDa ribosomal protein S6 kinase 1
p70 S6 kinase alpha
p70 ribosomal S6 kinase alpha
ribosomal protein S6 kinase I
ribosomal protein S6 kinase, 70kD, polypeptide 1
NP_001107806.1
NP_001350091.1
NP_082535.1
XP_006534378.1
XP_011247577.1
XP_011247578.1
XP_036012907.1
XP_036012908.1
XP_036012909.1
XP_036012910.1
XP_036012911.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114334.2NP_001107806.1  ribosomal protein S6 kinase beta-1 isoform 1

    See identical proteins and their annotated locations for NP_001107806.1

    Status: VALIDATED

    Source sequence(s)
    AK032724, AK135716, AL604063
    Consensus CDS
    CCDS48875.1
    UniProtKB/Swiss-Prot
    Q8BSK8, Q8CHX0
    UniProtKB/TrEMBL
    Q3UXD8
    Related
    ENSMUSP00000119715.2, ENSMUST00000154617.8
    Conserved Domains (1) summary
    cd05584
    Location:94416
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  2. NM_001363162.1NP_001350091.1  ribosomal protein S6 kinase beta-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL604063
    Conserved Domains (1) summary
    cd05584
    Location:41363
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  3. NM_028259.4NP_082535.1  ribosomal protein S6 kinase beta-1 isoform 2

    See identical proteins and their annotated locations for NP_082535.1

    Status: VALIDATED

    Source sequence(s)
    AL604063
    Consensus CDS
    CCDS25201.1
    UniProtKB/TrEMBL
    Q8C3J7
    Related
    ENSMUSP00000053188.3, ENSMUST00000058286.9
    Conserved Domains (1) summary
    cl21453
    Location:94195
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    86389695..86435711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157018.1XP_036012911.1  ribosomal protein S6 kinase beta-1 isoform X5

    Conserved Domains (1) summary
    cl21453
    Location:1157
    PKc_like; Protein Kinases, catalytic domain
  2. XM_036157014.1XP_036012907.1  ribosomal protein S6 kinase beta-1 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1213
    PKc_like; Protein Kinases, catalytic domain
  3. XM_036157016.1XP_036012909.1  ribosomal protein S6 kinase beta-1 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1213
    PKc_like; Protein Kinases, catalytic domain
  4. XM_036157017.1XP_036012910.1  ribosomal protein S6 kinase beta-1 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1213
    PKc_like; Protein Kinases, catalytic domain
  5. XM_036157015.1XP_036012908.1  ribosomal protein S6 kinase beta-1 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1213
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011249275.4XP_011247577.1  ribosomal protein S6 kinase beta-1 isoform X1

    Conserved Domains (1) summary
    cd05584
    Location:94416
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  7. XM_006534315.5XP_006534378.1  ribosomal protein S6 kinase beta-1 isoform X2

    Conserved Domains (1) summary
    cd05584
    Location:48336
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  8. XM_011249276.4XP_011247578.1  ribosomal protein S6 kinase beta-1 isoform X3

    Conserved Domains (1) summary
    cd05584
    Location:94409
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

RNA

  1. XR_004937046.1 RNA Sequence

  2. XR_004937048.1 RNA Sequence

  3. XR_004937047.1 RNA Sequence

  4. XR_001780060.3 RNA Sequence

  5. XR_003949511.2 RNA Sequence

  6. XR_003949513.1 RNA Sequence

  7. XR_879743.4 RNA Sequence

  8. XR_004937043.1 RNA Sequence

  9. XR_004937042.1 RNA Sequence

  10. XR_004937044.1 RNA Sequence

  11. XR_004937045.1 RNA Sequence