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Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 72508, updated on 23-Dec-2018

Summary

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Official Symbol
Rps6kb1provided by MGI
Official Full Name
ribosomal protein S6 kinase, polypeptide 1provided by MGI
Primary source
MGI:MGI:1270849
See related
Ensembl:ENSMUSG00000020516
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S6K; S6K1; p70s6k; P70S6K1; AA959758; AI256796; AI314060; p70 S6KA; p70-S6K 1; p70/85s6k; S6K-beta-1; 2610318I15Rik; p70 S6K-alpha
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.0), limb E14.5 (RPKM 4.8) and 26 other tissues See more
Orthologs
human all

Genomic context

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See Rps6kb1 in Genome Data Viewer
Location:
11; 11 C
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (86499009..86544807, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (86312511..86358309, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene ring finger protein 185 pseudogene Neighboring gene ring finger protein, transmembrane 1 Neighboring gene tubulin, delta 1 Neighboring gene microRNA 21a Neighboring gene vacuole membrane protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Absence of the kinase S6k1 mimics the effect of chronic endurance exercise on glucose tolerance and muscle oxidative stress. Binsch C, et al. Mol Metab, 2017 Nov. PMID 29107291, Free PMC Article
  2. Decreased Whole-Body Fat Mass Produced by Chronic Alcohol Consumption is Associated with Activation of S6K1-Mediated Protein Synthesis and Increased Autophagy in Epididymal White Adipose Tissue. Crowell KT, et al. Alcohol Clin Exp Res, 2016 Sep. PMID 27464336, Free PMC Article
  3. p70 ribosomal S6 kinase regulates subpleural fibrosis following transforming growth factor-α expression in the lung. Madala SK, et al. Am J Physiol Lung Cell Mol Physiol, 2016 Jan 15. PMID 26566903, Free PMC Article
  4. Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice. Smith MA, et al. Cell Rep, 2015 Apr 21. PMID 25865886, Free PMC Article
  5. p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/b1 integrin signaling activation. Ip CK, et al. Oncotarget, 2014 Oct 15. PMID 25193855, Free PMC Article

See all (237) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. DPP-4 inhibitor sitagliptin has effects on cardiac function, glycemia, and beta-cell function together with reducing S6K1 activation and IRS-1 and IRS-2 degradation in the obesity female mouse model
    Title: DPP-4 Inhibitor Sitagliptin Improves Cardiac Function and Glucose Homeostasis and Ameliorates <i>β</i>-Cell Dysfunction Together with Reducing S6K1 Activation and IRS-1 and IRS-2 Degradation in Obesity Female Mice.
  2. S6K1-dependent IRS-1pSer suppresses insulin signaling leading to insulin resistance, which is frequently observed in AD brains. Notably, miR-200b/c transfection of SH-SY5Y cells reduced the levels of IRS-1pSer. This finding indicates that miR-200b/c has the potential to alleviate insulin resistance via modulation of S6K1
    Title: Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer's disease models.
  3. Activation of S6K1-mediated protein synthesis and increased autophagy in white adipose tissue was detected in chronic alcohol fed animals.
    Title: Decreased Whole-Body Fat Mass Produced by Chronic Alcohol Consumption is Associated with Activation of S6K1-Mediated Protein Synthesis and Increased Autophagy in Epididymal White Adipose Tissue.
  4. we show that simultaneous inhibition of mTOR signaling to both S6K1 and 4E-BP1 is sufficient to reduce AKT-induced muscle growth and render it insensitive to the mTORC1-inhibitor rapamycin
    Title: S6K1 Is Required for Increasing Skeletal Muscle Force during Hypertrophy.
  5. S6K1 acts through multiple targets of the mTOR pathway to promote self-renewal and leukemia progression
    Title: S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance.
  6. transfection of cells with a constitutively active rapamycin-resistant p70S6K mutant could restore the mineralizing capacity of HtrA1-deficient mouse adipose-derived stromal cells.
    Title: Loss-of-Function of HtrA1 Abrogates All-Trans Retinoic Acid-Induced Osteogenic Differentiation of Mouse Adipose-Derived Stromal Cells Through Deficiencies in p70S6K Activation.
  7. We provide mechanistic evidence that S6K1's negative feedback to PI3K signaling is involved in axon growth inhibition, and show that phosphorylation of S6K1 is a more appropriate regeneration indicator than is S6 phosphorylation.
    Title: The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury.
  8. S6K1 phosphorylation of H2B mediates EZH2 trimethylation of H3 early in adipogenesis, contributing to the promotion of obesity.
    Title: S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis.
  9. the p70S6K isoforms have unique and redundant functions in mediating fibrogenic processes, including proliferation, migration.
    Title: Unique and Redundant Functions of p70 Ribosomal S6 Kinase Isoforms Regulate Mesenchymal Cell Proliferation and Migration in Pulmonary Fibrosis.
  10. Rcan2 and Rps6kb1 mutations both affect growth and body weight of mice, though likely through different mechanisms
    Title: A disputed evidence on obesity: comparison of the effects of Rcan2(-/-) and Rps6kb1(-/-) mutations on growth and body weight in C57BL/6J mice.
Submit: New GeneRIF Correction See all GeneRIFs (120)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Genotypes

Pathways from BioSystems

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  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
    Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
  • Acute myeloid leukemia, conserved biosystem (from KEGG)
    Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
  • Apelin signaling pathway, organism-specific biosystem (from KEGG)
    Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Breast cancer, organism-specific biosystem (from KEGG)
    Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Breast cancer, conserved biosystem (from KEGG)
    Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Choline metabolism in cancer, organism-specific biosystem (from KEGG)
    Choline metabolism in cancer, organism-specific biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
  • Choline metabolism in cancer, conserved biosystem (from KEGG)
    Choline metabolism in cancer, conserved biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
  • EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
    EGFR tyrosine kinase inhibitor resistance, organism-specific biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
  • EGFR tyrosine kinase inhibitor resistance, conserved biosystem (from KEGG)
    EGFR tyrosine kinase inhibitor resistance, conserved biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
  • Endocrine resistance, organism-specific biosystem (from KEGG)
    Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • Endocrine resistance, conserved biosystem (from KEGG)
    Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • ErbB signaling pathway, organism-specific biosystem (from KEGG)
    ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • ErbB signaling pathway, conserved biosystem (from KEGG)
    ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, organism-specific biosystem (from WikiPathways)
    Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, organism-specific biosystemThe signaling pathway that involves insulin-like growth factor 1 (IGF1), and a variety of other components that affect the pathway, plays an important role in the regulation of skeletal muscle growth...
  • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
    Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
  • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
    Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
  • Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
    Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
  • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
    HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
  • IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
    IGF1R signaling cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-2 Signaling Pathway, organism-specific biosystemIL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions rela...
  • IL-6 signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-6 signaling Pathway, organism-specific biosystem
    IL-6 signaling Pathway
  • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
    IRS-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
    IRS-related events triggered by IGF1R, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystem
    Insulin Signaling
  • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
    Insulin receptor signalling cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Insulin resistance, organism-specific biosystem (from KEGG)
    Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Longevity regulating pathway, organism-specific biosystem (from KEGG)
    Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
  • Longevity regulating pathway - multiple species, organism-specific biosystem (from KEGG)
    Longevity regulating pathway - multiple species, organism-specific biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
  • Longevity regulating pathway - multiple species, conserved biosystem (from KEGG)
    Longevity regulating pathway - multiple species, conserved biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
  • PI3K Cascade, organism-specific biosystem (from REACTOME)
    PI3K Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K/Akt/mTOR signaling pathway, organism-specific biosystem (from LIPID MAPS)
    PI3K/Akt/mTOR signaling pathway, organism-specific biosystem
    PI3K/Akt/mTOR signaling pathway
  • PKB-mediated events, organism-specific biosystem (from REACTOME)
    PKB-mediated events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
    Signaling by Insulin receptor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem
    TNF-alpha NF-kB Signaling Pathway
  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signalling, organism-specific biosystem (from REACTOME)
    mTOR signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • mTORC1-mediated signalling, organism-specific biosystem (from REACTOME)
    mTORC1-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 4732464A07Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
  
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
identical protein binding ISO
Inferred from Sequence Orthology
more info
  
kinase activity IEA
Inferred from Electronic Annotation
more info
  
nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
peptide binding ISO
Inferred from Sequence Orthology
more info
  
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
  
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
ribosomal protein S6 kinase activity ISO
Inferred from Sequence Orthology
more info
  
transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
TOR signaling ISO
Inferred from Sequence Orthology
more info
  
apoptotic process IEA
Inferred from Electronic Annotation
more info
  
behavioral fear response IGI
Inferred from Genetic Interaction
more info
 PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
  
cellular response to dexamethasone stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
cellular response to interferon-gamma IMP
Inferred from Mutant Phenotype
more info
 PubMed 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
 PubMed 
germ cell development IDA
Inferred from Direct Assay
more info
 PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
long-chain fatty acid import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
phosphorylation IEA
Inferred from Electronic Annotation
more info
  
positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
positive regulation of skeletal muscle tissue growth ISO
Inferred from Sequence Orthology
more info
  
positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
  
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
positive regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
positive regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
regulation of glucose import ISO
Inferred from Sequence Orthology
more info
  
regulation of translation IEA
Inferred from Electronic Annotation
more info
  
response to insulin ISO
Inferred from Sequence Orthology
more info
  
response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
  
cell surface ISO
Inferred from Sequence Orthology
more info
  
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
  
cytosol ISO
Inferred from Sequence Orthology
more info
  
membrane IEA
Inferred from Electronic Annotation
more info
  
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
  
neuron projection IEA
Inferred from Electronic Annotation
more info
  
nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
  
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribosomal protein S6 kinase beta-1
Names
70 kDa ribosomal protein S6 kinase 1
p70 S6 kinase alpha
p70 ribosomal S6 kinase alpha
ribosomal protein S6 kinase I
ribosomal protein S6 kinase, 70kD, polypeptide 1
NP_001107806.1
NP_082535.1
XP_006534377.1
XP_006534378.1
XP_006534380.1
XP_011247577.1
XP_011247578.1
XP_011247579.1
XP_017170280.1
XP_017170281.1
XP_017170282.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114334.2 → NP_001107806.1  ribosomal protein S6 kinase beta-1 isoform 1

    See identical proteins and their annotated locations for NP_001107806.1

    Status: VALIDATED

    Source sequence(s)
    AK032724, AK135716, AL604063
    Consensus CDS
    CCDS48875.1
    UniProtKB/Swiss-Prot
    Q8BSK8
    UniProtKB/TrEMBL
    Q3UXD8
    Related
    ENSMUSP00000119715.1, ENSMUST00000154617.7
    Conserved Domains (1) summary
    cd05584
    Location:94 → 416
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  2. NM_001363162.1 → NP_001350091.1  ribosomal protein S6 kinase beta-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL604063
    Conserved Domains (1) summary
    cd05584
    Location:41 → 363
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  3. NM_028259.4 → NP_082535.1  ribosomal protein S6 kinase beta-1 isoform 2

    See identical proteins and their annotated locations for NP_082535.1

    Status: VALIDATED

    Source sequence(s)
    AL604063
    Consensus CDS
    CCDS25201.1
    UniProtKB/TrEMBL
    Q8C3J7
    Related
    ENSMUSP00000053188.2, ENSMUST00000058286.8
    Conserved Domains (1) summary
    cl21453
    Location:94 → 195
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    86499009..86544807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249277.2 → XP_011247579.1  ribosomal protein S6 kinase beta-1 isoform X5

    See identical proteins and their annotated locations for XP_011247579.1

    Conserved Domains (2) summary
    smart00220
    Location:2 → 149
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1 → 213
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006534317.2 → XP_006534380.1  ribosomal protein S6 kinase beta-1 isoform X5

    See identical proteins and their annotated locations for XP_006534380.1

    Conserved Domains (2) summary
    smart00220
    Location:2 → 149
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1 → 213
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006534314.3 → XP_006534377.1  ribosomal protein S6 kinase beta-1 isoform X1

    Conserved Domains (1) summary
    cd05584
    Location:41 → 363
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  4. XM_006534315.3 → XP_006534378.1  ribosomal protein S6 kinase beta-1 isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:55 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05584
    Location:48 → 336
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  5. XM_011249275.2 → XP_011247577.1  ribosomal protein S6 kinase beta-1 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:91 → 352
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05584
    Location:94 → 416
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  6. XM_011249276.2 → XP_011247578.1  ribosomal protein S6 kinase beta-1 isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:91 → 352
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05584
    Location:94 → 409
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  7. XM_017314793.1 → XP_017170282.1  ribosomal protein S6 kinase beta-1 isoform X8

  8. XM_017314791.1 → XP_017170280.1  ribosomal protein S6 kinase beta-1 isoform X6

  9. XM_017314792.1 → XP_017170281.1  ribosomal protein S6 kinase beta-1 isoform X7

RNA

  1. XR_001780060.1 RNA Sequence

  2. XR_879743.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BSK8.2 GenPept UniProtKB/Swiss-Prot:Q8BSK8

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