RPS6KB1 ribosomal protein S6 kinase B1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RPS6KB1provided by HGNC
Official Full Name: ribosomal protein S6 kinase B1provided by HGNC
Primary source: HGNC:HGNC:10436
See related: Ensembl:ENSG00000108443 MIM:608938; AllianceGenome:HGNC:10436
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: S6K; PS6K; S6K1; STK14A; p70-S6K; p70 S6KA; p70-alpha; S6K-beta-1; p70(S6K)-alpha
Summary: This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
Expression: Ubiquitous expression in esophagus (RPKM 6.9), thyroid (RPKM 6.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q23.1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (59893121..59950574)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (60761869..60819318)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (57970482..58027935)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ribosomal protein S6 kinase beta-1 gene variants cause hypertrophic cardiomyopathy.
Title: Ribosomal protein S6 kinase beta-1 gene variants cause hypertrophic cardiomyopathy.
S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair.
Title: S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair.
Functional variants of RPS6KB1 and PIK3R1 in the autophagy pathway genes and risk of bladder cancer.
Title: Functional variants of RPS6KB1 and PIK3R1 in the autophagy pathway genes and risk of bladder cancer.
Nuclear S6K1 regulates cAMP-responsive element-dependent gene transcription through activation of mTOR signal pathway.
Title: Nuclear S6K1 regulates cAMP-responsive element-dependent gene transcription through activation of mTOR signal pathway.
mTORC1 induces eukaryotic translation initiation factor 4E interaction with TOS-S6 kinase 1 and its activation.
Title: mTORC1 induces eukaryotic translation initiation factor 4E interaction with TOS-S6 kinase 1 and its activation.
MiRNA-30e downregulation increases cancer cell proliferation, invasion and tumor growth through targeting RPS6KB1.
Title: MiRNA-30e downregulation increases cancer cell proliferation, invasion and tumor growth through targeting RPS6KB1.
Activation of Downstream mTORC1 Target Ribosomal Protein S6 Kinase (S6K) Can Be Found in a Subgroup of Dutch Patients with Granulomatous Pulmonary Disease.
Title: Activation of Downstream mTORC1 Target Ribosomal Protein S6 Kinase (S6K) Can Be Found in a Subgroup of Dutch Patients with Granulomatous Pulmonary Disease.
S6K1 Is Indispensible for Stress-Induced Microtubule Acetylation and Autophagic Flux.
Title: S6K1 Is Indispensible for Stress-Induced Microtubule Acetylation and Autophagic Flux.
IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas.
Title: IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas.
Upregulation of MTOR, RPS6KB1, and EIF4EBP1 in the whole blood samples of Iranian patients with multiple sclerosis compared to healthy controls.
Title: Upregulation of MTOR, RPS6KB1, and EIF4EBP1 in the whole blood samples of Iranian patients with multiple sclerosis compared to healthy controls.

Submit: New GeneRIF Correction See all GeneRIFs (266)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5	PubMed
Tat	tat	HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1)	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S1604 (e-PCR)
- UniSTS:39009

RH69849 (e-PCR)
- UniSTS:15737

G42204 (e-PCR)
- UniSTS:93307

WI-17810 (e-PCR)
- UniSTS:20107

MARC_10535-10536:1000147856:1 (e-PCR)
- UniSTS:267161

D17S1554 (e-PCR)
- UniSTS:61668

D17S1994 (e-PCR)
- UniSTS:6637

Homology

Homologs of the RPS6KB1 gene: The RPS6KB1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 445 organisms have orthologs with human gene RPS6KB1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables peptide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase 2A binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables protein serine/threonine/tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal protein S6 kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in TOR signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in TOR signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aging	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in behavioral fear response	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cellular response to dexamethasone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cellular response to type II interferon	IEA Inferred from Electronic Annotation more info
involved_in germ cell development	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid import into cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-term memory	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol-mediated signaling	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of skeletal muscle tissue growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein kinase B signaling	IEA Inferred from Electronic Annotation more info
involved_in regulation of glucose import	IEA Inferred from Electronic Annotation more info
involved_in response to electrical stimulus involved in regulation of muscle adaptation	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to glucagon	IEA Inferred from Electronic Annotation more info
involved_in response to glucose	IEA Inferred from Electronic Annotation more info
involved_in response to heat	IEA Inferred from Electronic Annotation more info
involved_in response to leucine	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
involved_in response to testosterone	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in skeletal muscle atrophy	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle contraction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal protein S6 kinase beta-1

Names: ribosomal protein S6 kinase I; ribosomal protein S6 kinase, 70kDa, polypeptide 1; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A

NP_001258971.1

EC 2.7.11.1

NP_001258972.1

EC 2.7.11.1

NP_001258973.1

EC 2.7.11.1

NP_001258989.1

EC 2.7.11.1

NP_001356598.1

EC 2.7.11.1

NP_001356599.1

EC 2.7.11.1

NP_001356600.1

EC 2.7.11.1

NP_001356601.1

EC 2.7.11.1

NP_001356602.1

EC 2.7.11.1

NP_001356603.1

EC 2.7.11.1

NP_001356604.1

EC 2.7.11.1

NP_001356605.1

EC 2.7.11.1

NP_001356606.1

EC 2.7.11.1

NP_001356607.1

EC 2.7.11.1

NP_001356608.1

EC 2.7.11.1

NP_003152.1

EC 2.7.11.1

XP_011523404.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029513.1 RefSeqGene

Range

5040..62493

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272042.2 → NP_001258971.1 ribosomal protein S6 kinase beta-1 isoform b

See identical proteins and their annotated locations for NP_001258971.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. This variant can initiate translation from two alternate in-frame AUG start codons. The isoform represented in this RefSeq (b) is derived from the first AUG start codon, and is shorter than isoform a.

Source sequence(s)

AC004686, AK297147, AK300202, BP359158, CA444907

Consensus CDS

CCDS62272.1

UniProtKB/Swiss-Prot

P23443

Related

ENSP00000441993.1, ENST00000443572.6

Conserved Domains (1) summary

cd05584
Location:94 → 393

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_001272043.2 → NP_001258972.1 ribosomal protein S6 kinase beta-1 isoform c

See identical proteins and their annotated locations for NP_001258972.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. This variant can initiate translation from two alternate in-frame AUG start codons. The isoform represented in this RefSeq (c) is derived from the first AUG start codon. It has a distinct C-terminus, and is shorter than isoform a.

Source sequence(s)

AC004686, BC053365, BP359158, CA444907

Consensus CDS

CCDS62271.1

UniProtKB/Swiss-Prot

P23443

Related

ENSP00000384335.3, ENST00000406116.7

Conserved Domains (1) summary

cd05584
Location:94 → 416

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_001272044.2 → NP_001258973.1 ribosomal protein S6 kinase beta-1 isoform d

See identical proteins and their annotated locations for NP_001258973.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternate exon in the 5' region, and initiates translation at the third in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AC004686, AK297147, BP359158, CA444907

Consensus CDS

CCDS62273.1

UniProtKB/Swiss-Prot

P23443

Related

ENSP00000376744.3, ENST00000393021.7

Conserved Domains (1) summary

cd05584
Location:41 → 363

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_001272060.2 → NP_001258989.1 ribosomal protein S6 kinase beta-1 isoform e

See identical proteins and their annotated locations for NP_001258989.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) can initiate translation from two alternate in-frame AUG start codons. The isoform represented in this RefSeq (e, also known as p70 or alpha II) is derived from the second AUG start codon, and is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AC004686, AK297147, AK312875, BP359158, CA444907

UniProtKB/Swiss-Prot

P23443

Conserved Domains (2) summary

smart00220
Location:68 → 329

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05584
Location:71 → 393

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_001369669.1 → NP_001356598.1 ribosomal protein S6 kinase beta-1 isoform f

Status: REVIEWED

Source sequence(s)

AC004686

Conserved Domains (1) summary

cd05584
Location:94 → 380

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_001369670.1 → NP_001356599.1 ribosomal protein S6 kinase beta-1 isoform g

Status: REVIEWED

Source sequence(s)

AC004686

Conserved Domains (1) summary

cd05584
Location:41 → 342

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_001369671.1 → NP_001356600.1 ribosomal protein S6 kinase beta-1 isoform h

Status: REVIEWED

Source sequence(s)

AC004686

Conserved Domains (1) summary

cd05584
Location:48 → 336

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_001369672.1 → NP_001356601.1 ribosomal protein S6 kinase beta-1 isoform i

Status: REVIEWED

Source sequence(s)

AC004686

Conserved Domains (1) summary

cd05584
Location:41 → 327

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_001369673.1 → NP_001356602.1 ribosomal protein S6 kinase beta-1 isoform j

Status: REVIEWED

Source sequence(s)

AC004686

Conserved Domains (1) summary

cl21453
Location:41 → 142

PKc_like; Protein Kinases, catalytic domain
NM_001369674.1 → NP_001356603.1 ribosomal protein S6 kinase beta-1 isoform k

Status: REVIEWED

Description

Transcript Variant: This variant (10), as well as variant 11, encodes isoform k.

Source sequence(s)

AC004686

Conserved Domains (1) summary

cl21453
Location:94 → 210

PKc_like; Protein Kinases, catalytic domain
NM_001369675.1 → NP_001356604.1 ribosomal protein S6 kinase beta-1 isoform k

Status: REVIEWED

Description

Transcript Variant: This variant (11), as well as variant 10, encodes isoform k.

Source sequence(s)

AC004686

Conserved Domains (1) summary

cl21453
Location:94 → 210

PKc_like; Protein Kinases, catalytic domain
NM_001369676.1 → NP_001356605.1 ribosomal protein S6 kinase beta-1 isoform l

Status: REVIEWED

Description

Transcript Variant: This variant (12), as well as variants 13-15, encodes isoform l.

Source sequence(s)

AC004686

Conserved Domains (1) summary

cl21453
Location:94 → 195

PKc_like; Protein Kinases, catalytic domain
NM_001369677.1 → NP_001356606.1 ribosomal protein S6 kinase beta-1 isoform l

Status: REVIEWED

Description

Transcript Variant: This variant (13), as well as variants 12, 14, and 15, encodes isoform l.

Source sequence(s)

AC004686

Conserved Domains (1) summary

cl21453
Location:94 → 195

PKc_like; Protein Kinases, catalytic domain
NM_001369678.1 → NP_001356607.1 ribosomal protein S6 kinase beta-1 isoform l

Status: REVIEWED

Description

Transcript Variant: This variant (14), as well as variants 12, 13, and 15, encodes isoform l.

Source sequence(s)

AC004686

Conserved Domains (1) summary

cl21453
Location:94 → 195

PKc_like; Protein Kinases, catalytic domain
NM_001369679.1 → NP_001356608.1 ribosomal protein S6 kinase beta-1 isoform l

Status: REVIEWED

Description

Transcript Variant: This variant (15), as well as variants 12-14, encodes isoform l.

Source sequence(s)

AC004686

Conserved Domains (1) summary

cl21453
Location:94 → 195

PKc_like; Protein Kinases, catalytic domain
NM_003161.4 → NP_003152.1 ribosomal protein S6 kinase beta-1 isoform a

See identical proteins and their annotated locations for NP_003152.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) can initiate translation from two alternate in-frame AUG start codons. The isoform represented in this RefSeq (a, also known as p85 or alpha I) is derived from the first AUG start codon, and is the longest isoform.

Source sequence(s)

AC004686, AK297147, AK312875, BP359158, CA444907

Consensus CDS

CCDS11621.1

UniProtKB/Swiss-Prot

P23443, Q7Z721

Related

ENSP00000225577.4, ENST00000225577.9

Conserved Domains (1) summary

cd05584
Location:94 → 416

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

RNA

NR_161455.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004686
NR_161456.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004686
NR_161457.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004686
NR_161458.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004686
NR_161459.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004686
NR_161460.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004686
NR_161461.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004686
NR_161462.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004686

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

59893121..59950574

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011525102.4 → XP_011523404.1 ribosomal protein S6 kinase beta-1 isoform X1

Conserved Domains (2) summary

smart00220
Location:91 → 352

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05584
Location:94 → 378

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase