RPS6KB1 ribosomal protein S6 kinase B1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RPS6KB1provided by HGNC
Official Full Name: ribosomal protein S6 kinase B1provided by HGNC
Primary source: HGNC:HGNC:10436
See related: Ensembl:ENSG00000108443 MIM:608938; AllianceGenome:HGNC:10436
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: S6K; PS6K; S6K1; STK14A; p70-S6K; p70 S6KA; p70-alpha; S6K-beta-1; p70(S6K)-alpha
Summary: This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
Expression: Ubiquitous expression in esophagus (RPKM 6.9), thyroid (RPKM 6.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q23.1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (59893121..59950574)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (60761869..60819318)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (57970482..58027935)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lactate-upregulated ARG2 expression induces cellular senescence in fibroblast-like synoviocytes of osteoarthritis via activating the mTOR/S6K1 signaling pathway.
Title: Lactate-upregulated ARG2 expression induces cellular senescence in fibroblast-like synoviocytes of osteoarthritis via activating the mTOR/S6K1 signaling pathway.
IRGM is a novel regulator of PD-L1 via promoting S6K1-mediated phosphorylation of YBX1 in hepatocellular carcinoma.
Title: IRGM is a novel regulator of PD-L1 via promoting S6K1-mediated phosphorylation of YBX1 in hepatocellular carcinoma.
Correlation and influencing factors analysis of colorectal polyps with Helicobacter pylori Infection and p-S6K1 expression.
Title: Correlation and influencing factors analysis of colorectal polyps with Helicobacter pylori Infection and p-S6K1 expression.
AMPK/mTOR/p70S6K axis prevents apoptosis of Porphyromonas gingivalis-infected gingival epithelial cells via Bad[Ser136] phosphorylation.
Title: AMPK/mTOR/p70S6K axis prevents apoptosis of Porphyromonas gingivalis-infected gingival epithelial cells via Bad(Ser136) phosphorylation.
EIF4A3 Acts on the PI3K-AKT-ERK1/2-P70S6K Pathway through FLOT1 to Influence the Development of Lung Adenocarcinoma.
Title: EIF4A3 Acts on the PI3K-AKT-ERK1/2-P70S6K Pathway through FLOT1 to Influence the Development of Lung Adenocarcinoma.
Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma.
Title: Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma.
Tumor P70S6K hyperactivation is inversely associated with tumor-infiltrating lymphocytes in triple-negative breast cancer.
Title: Tumor P70S6K hyperactivation is inversely associated with tumor-infiltrating lymphocytes in triple-negative breast cancer.
Ribosomal protein S6 kinase beta-1 gene variants cause hypertrophic cardiomyopathy.
Title: Ribosomal protein S6 kinase beta-1 gene variants cause hypertrophic cardiomyopathy.
S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair.
Title: S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair.
Functional variants of RPS6KB1 and PIK3R1 in the autophagy pathway genes and risk of bladder cancer.
Title: Functional variants of RPS6KB1 and PIK3R1 in the autophagy pathway genes and risk of bladder cancer.

Submit: New GeneRIF Correction See all GeneRIFs (271)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5	PubMed
Tat	tat	HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1)	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S1604 (e-PCR)
- UniSTS:39009

RH69849 (e-PCR)
- UniSTS:15737

G42204 (e-PCR)
- UniSTS:93307

WI-17810 (e-PCR)
- UniSTS:20107

MARC_10535-10536:1000147856:1 (e-PCR)
- UniSTS:267161

D17S1554 (e-PCR)
- UniSTS:61668

D17S1994 (e-PCR)
- UniSTS:6637

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables protein serine/threonine/tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in TOR signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within TORC2 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within autophagosome assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within behavioral fear response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to dexamethasone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nutrient	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to type II interferon	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytoplasmic translation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within germ cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid import into cell	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid import into cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of TORC2 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of TORC2 signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TORC2 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol-mediated signaling	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of translational initiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal protein S6 kinase beta-1

Names: ribosomal protein S6 kinase I; ribosomal protein S6 kinase, 70kDa, polypeptide 1; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A

NP_001258971.1

EC 2.7.11.1

NP_001258972.1

EC 2.7.11.1

NP_001258973.1

EC 2.7.11.1

NP_001258989.1

EC 2.7.11.1

NP_001356598.1

EC 2.7.11.1

NP_001356599.1

EC 2.7.11.1

NP_001356600.1

EC 2.7.11.1

NP_001356601.1

EC 2.7.11.1

NP_001356602.1

EC 2.7.11.1

NP_001356603.1

EC 2.7.11.1

NP_001356604.1

EC 2.7.11.1

NP_001356605.1

EC 2.7.11.1

NP_001356606.1

EC 2.7.11.1

NP_001356607.1

EC 2.7.11.1

NP_001356608.1

EC 2.7.11.1

NP_003152.1

EC 2.7.11.1

XP_011523404.1

EC 2.7.11.1

XP_054172845.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029513.1 RefSeqGene

Range

5040..62493

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272042.2 → NP_001258971.1 ribosomal protein S6 kinase beta-1 isoform b

See identical proteins and their annotated locations for NP_001258971.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. This variant can initiate translation from two alternate in-frame AUG start codons. The isoform represented in this RefSeq (b) is derived from the first AUG start codon, and is shorter than isoform a.

Source sequence(s)

AC004686, AK297147, AK300202, BP359158, CA444907

Consensus CDS

CCDS62272.1

UniProtKB/TrEMBL

B4DDM0

Related

ENSP00000441993.1, ENST00000443572.6

Conserved Domains (1) summary

cd05584
Location:94 → 393

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_001272043.2 → NP_001258972.1 ribosomal protein S6 kinase beta-1 isoform c

See identical proteins and their annotated locations for NP_001258972.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. This variant can initiate translation from two alternate in-frame AUG start codons. The isoform represented in this RefSeq (c) is derived from the first AUG start codon. It has a distinct C-terminus, and is shorter than isoform a.

Source sequence(s)

AC004686, BC053365, BP359158, CA444907

Consensus CDS

CCDS62271.1

UniProtKB/Swiss-Prot

P23443

Related

ENSP00000384335.3, ENST00000406116.7

Conserved Domains (1) summary

cd05584
Location:94 → 416

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_001272044.2 → NP_001258973.1 ribosomal protein S6 kinase beta-1 isoform d

See identical proteins and their annotated locations for NP_001258973.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternate exon in the 5' region, and initiates translation at the third in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AC004686, AK297147, BP359158, CA444907

Consensus CDS

CCDS62273.1

UniProtKB/TrEMBL

B4DDM0

Related

ENSP00000376744.3, ENST00000393021.7

Conserved Domains (1) summary

cd05584
Location:41 → 363

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_001272060.2 → NP_001258989.1 ribosomal protein S6 kinase beta-1 isoform e

See identical proteins and their annotated locations for NP_001258989.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) can initiate translation from two alternate in-frame AUG start codons. The isoform represented in this RefSeq (e, also known as p70 or alpha II) is derived from the second AUG start codon, and is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AC004686, AK297147, AK312875, BP359158, CA444907

UniProtKB/TrEMBL

B4DDM0

Conserved Domains (2) summary

smart00220
Location:68 → 329

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05584
Location:71 → 393

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_001369669.1 → NP_001356598.1 ribosomal protein S6 kinase beta-1 isoform f

Status: REVIEWED

Source sequence(s)

AC004686

UniProtKB/TrEMBL

B4DDM0

Conserved Domains (1) summary

cd05584
Location:94 → 380

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_001369670.1 → NP_001356599.1 ribosomal protein S6 kinase beta-1 isoform g

Status: REVIEWED

Source sequence(s)

AC004686

UniProtKB/TrEMBL

B4DDM0

Conserved Domains (1) summary

cd05584
Location:41 → 342

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_001369671.1 → NP_001356600.1 ribosomal protein S6 kinase beta-1 isoform h

Status: REVIEWED

Source sequence(s)

AC004686

UniProtKB/TrEMBL

B4DDM0

Conserved Domains (1) summary

cd05584
Location:48 → 336

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_001369672.1 → NP_001356601.1 ribosomal protein S6 kinase beta-1 isoform i

Status: REVIEWED

Source sequence(s)

AC004686

UniProtKB/TrEMBL

B4DDM0

Conserved Domains (1) summary

cd05584
Location:41 → 327

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
NM_001369673.1 → NP_001356602.1 ribosomal protein S6 kinase beta-1 isoform j

Status: REVIEWED

Source sequence(s)

AC004686

Conserved Domains (1) summary

cl21453
Location:41 → 142

PKc_like; Protein Kinases, catalytic domain
NM_001369674.1 → NP_001356603.1 ribosomal protein S6 kinase beta-1 isoform k

Status: REVIEWED

Description

Transcript Variant: This variant (10), as well as variant 11, encodes isoform k.

Source sequence(s)

AC004686

Conserved Domains (1) summary

cl21453
Location:94 → 210

PKc_like; Protein Kinases, catalytic domain
NM_001369675.1 → NP_001356604.1 ribosomal protein S6 kinase beta-1 isoform k

Status: REVIEWED

Description

Transcript Variant: This variant (11), as well as variant 10, encodes isoform k.

Source sequence(s)

AC004686

Conserved Domains (1) summary

cl21453
Location:94 → 210

PKc_like; Protein Kinases, catalytic domain
NM_001369676.1 → NP_001356605.1 ribosomal protein S6 kinase beta-1 isoform l

Status: REVIEWED

Description

Transcript Variant: This variant (12), as well as variants 13-15, encodes isoform l.

Source sequence(s)

AC004686

Conserved Domains (1) summary

cl21453
Location:94 → 195

PKc_like; Protein Kinases, catalytic domain
NM_001369677.1 → NP_001356606.1 ribosomal protein S6 kinase beta-1 isoform l

Status: REVIEWED

Description

Transcript Variant: This variant (13), as well as variants 12, 14, and 15, encodes isoform l.

Source sequence(s)

AC004686

Conserved Domains (1) summary

cl21453
Location:94 → 195

PKc_like; Protein Kinases, catalytic domain
NM_001369678.1 → NP_001356607.1 ribosomal protein S6 kinase beta-1 isoform l

Status: REVIEWED

Description

Transcript Variant: This variant (14), as well as variants 12, 13, and 15, encodes isoform l.

Source sequence(s)

AC004686

Conserved Domains (1) summary

cl21453
Location:94 → 195

PKc_like; Protein Kinases, catalytic domain
NM_001369679.1 → NP_001356608.1 ribosomal protein S6 kinase beta-1 isoform l

Status: REVIEWED

Description

Transcript Variant: This variant (15), as well as variants 12-14, encodes isoform l.

Source sequence(s)

AC004686

Conserved Domains (1) summary

cl21453
Location:94 → 195

PKc_like; Protein Kinases, catalytic domain
NM_003161.4 → NP_003152.1 ribosomal protein S6 kinase beta-1 isoform a

See identical proteins and their annotated locations for NP_003152.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) can initiate translation from two alternate in-frame AUG start codons. The isoform represented in this RefSeq (a, also known as p85 or alpha I) is derived from the first AUG start codon, and is the longest isoform.

Source sequence(s)

AC004686, AK297147, AK312875, BP359158, CA444907

Consensus CDS

CCDS11621.1

UniProtKB/Swiss-Prot

B2R779, B4DLT4, B4DTG1, E7ESB8, F6UYM1, P23443, Q7Z721

UniProtKB/TrEMBL

B4DDM0

Related

ENSP00000225577.4, ENST00000225577.9

Conserved Domains (1) summary

cd05584
Location:94 → 416

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

RNA

NR_161455.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004686
NR_161456.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004686
NR_161457.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004686
NR_161458.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004686
NR_161459.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004686
NR_161460.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004686
NR_161461.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004686
NR_161462.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004686

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

59893121..59950574

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011525102.4 → XP_011523404.1 ribosomal protein S6 kinase beta-1 isoform X1

Conserved Domains (2) summary

smart00220
Location:91 → 352

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05584
Location:94 → 378

STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase