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RPS6KB1 ribosomal protein S6 kinase B1 [ Homo sapiens (human) ]

Gene ID: 6198, updated on 2-Mar-2021

Summary

Official Symbol
RPS6KB1provided by HGNC
Official Full Name
ribosomal protein S6 kinase B1provided by HGNC
Primary source
HGNC:HGNC:10436
See related
Ensembl:ENSG00000108443 MIM:608938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S6K; PS6K; S6K1; STK14A; p70-S6K; p70 S6KA; p70-alpha; S6K-beta-1; p70(S6K)-alpha
Summary
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in esophagus (RPKM 6.9), thyroid (RPKM 6.8) and 25 other tissues See more
Orthologs
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Genomic context

See RPS6KB1 in Genome Data Viewer
Location:
17q23.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (59893121..59950574)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (57970482..58027935)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 450, pseudogene Neighboring gene tubulin delta 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B8 pseudogene 2 Neighboring gene ribosomal protein S29 pseudogene 21 Neighboring gene TBC1D3P1-DHX40P1 readthrough, transcribed pseudogene Neighboring gene ring finger protein, transmembrane 1 Neighboring gene RNFT1 divergent transcript Neighboring gene DEAH-box helicase 40 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5 PubMed
Tat tat HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity TAS
Traceable Author Statement
more info
 
peptide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase 2A binding IEA
Inferred from Electronic Annotation
more info
 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TOR signaling IDA
Inferred from Direct Assay
more info
PubMed 
TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
cell migration IEA
Inferred from Electronic Annotation
more info
 
cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
germ cell development IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid import into cell ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term memory IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
PubMed 
positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of skeletal muscle tissue growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to electrical stimulus involved in regulation of muscle adaptation IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to glucagon IEA
Inferred from Electronic Annotation
more info
 
response to glucose IEA
Inferred from Electronic Annotation
more info
 
response to heat IEA
Inferred from Electronic Annotation
more info
 
response to leucine IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
response to nutrient levels IDA
Inferred from Direct Assay
more info
PubMed 
response to testosterone IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
response to wounding IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
skeletal muscle atrophy IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle contraction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribosomal protein S6 kinase beta-1
Names
ribosomal protein S6 kinase I
ribosomal protein S6 kinase, 70kDa, polypeptide 1
serine/threonine kinase 14 alpha
serine/threonine-protein kinase 14A
NP_001258971.1
NP_001258972.1
NP_001258973.1
NP_001258989.1
NP_001356598.1
NP_001356599.1
NP_001356600.1
NP_001356601.1
NP_001356602.1
NP_001356603.1
NP_001356604.1
NP_001356605.1
NP_001356606.1
NP_001356607.1
NP_001356608.1
NP_003152.1
XP_011523404.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029513.1 RefSeqGene

    Range
    5040..62493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272042.2NP_001258971.1  ribosomal protein S6 kinase beta-1 isoform b

    See identical proteins and their annotated locations for NP_001258971.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. This variant can initiate translation from two alternate in-frame AUG start codons. The isoform represented in this RefSeq (b) is derived from the first AUG start codon, and is shorter than isoform a.
    Source sequence(s)
    AC004686, AK297147, AK300202, BP359158, CA444907
    Consensus CDS
    CCDS62272.1
    UniProtKB/Swiss-Prot
    P23443
    Related
    ENSP00000441993.1, ENST00000443572.6
    Conserved Domains (1) summary
    cd05584
    Location:94393
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  2. NM_001272043.2NP_001258972.1  ribosomal protein S6 kinase beta-1 isoform c

    See identical proteins and their annotated locations for NP_001258972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. This variant can initiate translation from two alternate in-frame AUG start codons. The isoform represented in this RefSeq (c) is derived from the first AUG start codon. It has a distinct C-terminus, and is shorter than isoform a.
    Source sequence(s)
    AC004686, BC053365, BP359158, CA444907
    Consensus CDS
    CCDS62271.1
    UniProtKB/Swiss-Prot
    P23443
    Related
    ENSP00000384335.3, ENST00000406116.7
    Conserved Domains (1) summary
    cd05584
    Location:94416
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  3. NM_001272044.2NP_001258973.1  ribosomal protein S6 kinase beta-1 isoform d

    See identical proteins and their annotated locations for NP_001258973.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' region, and initiates translation at the third in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC004686, AK297147, BP359158, CA444907
    Consensus CDS
    CCDS62273.1
    UniProtKB/Swiss-Prot
    P23443
    Related
    ENSP00000376744.3, ENST00000393021.7
    Conserved Domains (1) summary
    cd05584
    Location:41363
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  4. NM_001272060.2NP_001258989.1  ribosomal protein S6 kinase beta-1 isoform e

    See identical proteins and their annotated locations for NP_001258989.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) can initiate translation from two alternate in-frame AUG start codons. The isoform represented in this RefSeq (e, also known as p70 or alpha II) is derived from the second AUG start codon, and is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC004686, AK297147, AK312875, BP359158, CA444907
    UniProtKB/Swiss-Prot
    P23443
    Conserved Domains (2) summary
    smart00220
    Location:68329
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05584
    Location:71393
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  5. NM_001369669.1NP_001356598.1  ribosomal protein S6 kinase beta-1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cd05584
    Location:94380
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  6. NM_001369670.1NP_001356599.1  ribosomal protein S6 kinase beta-1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cd05584
    Location:41342
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  7. NM_001369671.1NP_001356600.1  ribosomal protein S6 kinase beta-1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cd05584
    Location:48336
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  8. NM_001369672.1NP_001356601.1  ribosomal protein S6 kinase beta-1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cd05584
    Location:41327
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  9. NM_001369673.1NP_001356602.1  ribosomal protein S6 kinase beta-1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cl21453
    Location:41142
    PKc_like; Protein Kinases, catalytic domain
  10. NM_001369674.1NP_001356603.1  ribosomal protein S6 kinase beta-1 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variant 11, encodes isoform k.
    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cl21453
    Location:94210
    PKc_like; Protein Kinases, catalytic domain
  11. NM_001369675.1NP_001356604.1  ribosomal protein S6 kinase beta-1 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 10, encodes isoform k.
    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cl21453
    Location:94210
    PKc_like; Protein Kinases, catalytic domain
  12. NM_001369676.1NP_001356605.1  ribosomal protein S6 kinase beta-1 isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 13-15, encodes isoform l.
    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cl21453
    Location:94195
    PKc_like; Protein Kinases, catalytic domain
  13. NM_001369677.1NP_001356606.1  ribosomal protein S6 kinase beta-1 isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 12, 14, and 15, encodes isoform l.
    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cl21453
    Location:94195
    PKc_like; Protein Kinases, catalytic domain
  14. NM_001369678.1NP_001356607.1  ribosomal protein S6 kinase beta-1 isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 12, 13, and 15, encodes isoform l.
    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cl21453
    Location:94195
    PKc_like; Protein Kinases, catalytic domain
  15. NM_001369679.1NP_001356608.1  ribosomal protein S6 kinase beta-1 isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 12-14, encodes isoform l.
    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cl21453
    Location:94195
    PKc_like; Protein Kinases, catalytic domain
  16. NM_003161.4NP_003152.1  ribosomal protein S6 kinase beta-1 isoform a

    See identical proteins and their annotated locations for NP_003152.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) can initiate translation from two alternate in-frame AUG start codons. The isoform represented in this RefSeq (a, also known as p85 or alpha I) is derived from the first AUG start codon, and is the longest isoform.
    Source sequence(s)
    AC004686, AK297147, AK312875, BP359158, CA444907
    Consensus CDS
    CCDS11621.1
    UniProtKB/Swiss-Prot
    P23443
    Related
    ENSP00000225577.4, ENST00000225577.9
    Conserved Domains (1) summary
    cd05584
    Location:94416
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

RNA

  1. NR_161455.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004686
  2. NR_161456.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004686
  3. NR_161457.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004686
  4. NR_161458.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004686
  5. NR_161459.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004686
  6. NR_161460.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004686
  7. NR_161461.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004686
  8. NR_161462.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004686

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    59893121..59950574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525102.3XP_011523404.1  ribosomal protein S6 kinase beta-1 isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:91352
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05584
    Location:94378
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

RNA

  1. XR_002958051.1 RNA Sequence

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