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RPS6KB1 ribosomal protein S6 kinase B1 [ Homo sapiens (human) ]

Gene ID: 6198, updated on 2-Mar-2021

Summary

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Official Symbol
RPS6KB1provided by HGNC
Official Full Name
ribosomal protein S6 kinase B1provided by HGNC
Primary source
HGNC:HGNC:10436
See related
Ensembl:ENSG00000108443 MIM:608938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S6K; PS6K; S6K1; STK14A; p70-S6K; p70 S6KA; p70-alpha; S6K-beta-1; p70(S6K)-alpha
Summary
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in esophagus (RPKM 6.9), thyroid (RPKM 6.8) and 25 other tissues See more
Orthologs
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Genomic context

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See RPS6KB1 in Genome Data Viewer
Location:
17q23.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (59893121..59950574)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (57970482..58027935)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 450, pseudogene Neighboring gene tubulin delta 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B8 pseudogene 2 Neighboring gene ribosomal protein S29 pseudogene 21 Neighboring gene TBC1D3P1-DHX40P1 readthrough, transcribed pseudogene Neighboring gene ring finger protein, transmembrane 1 Neighboring gene RNFT1 divergent transcript Neighboring gene DEAH-box helicase 40 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inhibition of p70 isoforms of S6K1 induces anoikis to prevent transformed human hepatocyte growth. Patra T, et al. Life Sci, 2021 Jan 15. PMID 33189822
  2. Regulation of Mumps Virus Replication and Transcription by Kinase RPS6KB1. Briggs K, et al. J Virol, 2020 Jun 1. PMID 32295907, Free PMC Article
  3. Predicting Radiation Resistance in Breast Cancer with Expression Status of Phosphorylated S6K1. Choi J, et al. Sci Rep, 2020 Jan 20. PMID 31959810, Free PMC Article
  4. Direct imaging of the recruitment and phosphorylation of S6K1 in the mTORC1 pathway in living cells. Ahmed AR, et al. Sci Rep, 2019 Mar 4. PMID 30833605, Free PMC Article
  5. Suppression of ribosomal protein RPS6KB1 by Nexrutine increases sensitivity of prostate tumors to radiation. Hussain SS, et al. Cancer Lett, 2018 Oct 1. PMID 30003927

See all (396) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of p70 isoforms of S6K1 induces anoikis to prevent transformed human hepatocyte growth.
    Title: Inhibition of p70 isoforms of S6K1 induces anoikis to prevent transformed human hepatocyte growth.
  2. Benzoxazole Derivative K313 Induces Cell Cycle Arrest, Apoptosis and Autophagy Blockage and Suppresses mTOR/p70S6K Pathway in Nalm-6 and Daudi Cells.
    Title: Benzoxazole Derivative K313 Induces Cell Cycle Arrest, Apoptosis and Autophagy Blockage and Suppresses mTOR/p70S6K Pathway in Nalm-6 and Daudi Cells.
  3. Predicting Radiation Resistance in Breast Cancer with Expression Status of Phosphorylated S6K1.
    Title: Predicting Radiation Resistance in Breast Cancer with Expression Status of Phosphorylated S6K1.
  4. The association of aberrant expression of NLRP3 and p-S6K1 in colorectal cancer.
    Title: The association of aberrant expression of NLRP3 and p-S6K1 in colorectal cancer.
  5. Regulation of Mumps Virus Replication and Transcription by Kinase RPS6KB1.
    Title: Regulation of Mumps Virus Replication and Transcription by Kinase RPS6KB1.
  6. Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer.
    Title: Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer.
  7. Circular RNA hsa_circ_0006168 contributes to cell proliferation, migration and invasion in esophageal cancer by regulating miR-384/RBBP7 axis via activation of S6K/S6 pathway.
    Title: Circular RNA hsa_circ_0006168 contributes to cell proliferation, migration and invasion in esophageal cancer by regulating miR-384/RBBP7 axis via activation of S6K/S6 pathway.
  8. Ginsenoside CK induces apoptosis and suppresses proliferation and invasion of human osteosarcoma cells through the PI3K/mTOR/p70S6K1 pathway.
    Title: Ginsenoside CK induces apoptosis and suppresses proliferation and invasion of human osteosarcoma cells through the PI3K/mTOR/p70S6K1 pathway.
  9. Direct imaging of the recruitment and phosphorylation of S6K1 in the mTORC1 pathway in living cells.
    Title: Direct imaging of the recruitment and phosphorylation of S6K1 in the mTORC1 pathway in living cells.
  10. Non-canonical Raf-1/p70S6K signalling in non-small-cell lung cancer.
    Title: Non-canonical Raf-1/p70S6K signalling in non-small-cell lung cancer.
Submit: New GeneRIF Correction See all GeneRIFs (254)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5 PubMed
Tat tat HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
  
PDZ domain binding IEA
Inferred from Electronic Annotation
more info
  
identical protein binding IEA
Inferred from Electronic Annotation
more info
  
kinase activity TAS
Traceable Author Statement
more info
  
peptide binding IEA
Inferred from Electronic Annotation
more info
  
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
protein phosphatase 2A binding IEA
Inferred from Electronic Annotation
more info
  
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
TOR signaling IDA
Inferred from Direct Assay
more info
 PubMed 
TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
aging IEA
Inferred from Electronic Annotation
more info
  
apoptotic process IEA
Inferred from Electronic Annotation
more info
  
behavioral fear response IEA
Inferred from Electronic Annotation
more info
  
cell migration IEA
Inferred from Electronic Annotation
more info
  
cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
  
cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cellular response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
  
germ cell development IEA
Inferred from Electronic Annotation
more info
  
long-chain fatty acid import into cell ISS
Inferred from Sequence or Structural Similarity
more info
  
long-term memory IEA
Inferred from Electronic Annotation
more info
  
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
 PubMed 
positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of skeletal muscle tissue growth IEA
Inferred from Electronic Annotation
more info
  
positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
  
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
  
regulation of glucose import IEA
Inferred from Electronic Annotation
more info
  
response to drug IEA
Inferred from Electronic Annotation
more info
  
response to electrical stimulus involved in regulation of muscle adaptation IEA
Inferred from Electronic Annotation
more info
  
response to ethanol IEA
Inferred from Electronic Annotation
more info
  
response to glucagon IEA
Inferred from Electronic Annotation
more info
  
response to glucose IEA
Inferred from Electronic Annotation
more info
  
response to heat IEA
Inferred from Electronic Annotation
more info
  
response to leucine IEA
Inferred from Electronic Annotation
more info
  
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
  
response to nutrient IEA
Inferred from Electronic Annotation
more info
  
response to nutrient levels IDA
Inferred from Direct Assay
more info
 PubMed 
response to testosterone IEA
Inferred from Electronic Annotation
more info
  
response to toxic substance IEA
Inferred from Electronic Annotation
more info
  
response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
  
response to wounding IEA
Inferred from Electronic Annotation
more info
  
signal transduction TAS
Traceable Author Statement
more info
 PubMed 
skeletal muscle atrophy IEA
Inferred from Electronic Annotation
more info
  
skeletal muscle contraction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
  
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cytosol TAS
Traceable Author Statement
more info
  
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
neuron projection IEA
Inferred from Electronic Annotation
more info
  
nucleoplasm IDA
Inferred from Direct Assay
more info
  
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal protein S6 kinase beta-1
Names
ribosomal protein S6 kinase I
ribosomal protein S6 kinase, 70kDa, polypeptide 1
serine/threonine kinase 14 alpha
serine/threonine-protein kinase 14A
NP_001258971.1
NP_001258972.1
NP_001258973.1
NP_001258989.1
NP_001356598.1
NP_001356599.1
NP_001356600.1
NP_001356601.1
NP_001356602.1
NP_001356603.1
NP_001356604.1
NP_001356605.1
NP_001356606.1
NP_001356607.1
NP_001356608.1
NP_003152.1
XP_011523404.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029513.1 RefSeqGene

    Range
    5040..62493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272042.2 → NP_001258971.1  ribosomal protein S6 kinase beta-1 isoform b

    See identical proteins and their annotated locations for NP_001258971.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. This variant can initiate translation from two alternate in-frame AUG start codons. The isoform represented in this RefSeq (b) is derived from the first AUG start codon, and is shorter than isoform a.
    Source sequence(s)
    AC004686, AK297147, AK300202, BP359158, CA444907
    Consensus CDS
    CCDS62272.1
    UniProtKB/Swiss-Prot
    P23443
    Related
    ENSP00000441993.1, ENST00000443572.6
    Conserved Domains (1) summary
    cd05584
    Location:94 → 393
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  2. NM_001272043.2 → NP_001258972.1  ribosomal protein S6 kinase beta-1 isoform c

    See identical proteins and their annotated locations for NP_001258972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. This variant can initiate translation from two alternate in-frame AUG start codons. The isoform represented in this RefSeq (c) is derived from the first AUG start codon. It has a distinct C-terminus, and is shorter than isoform a.
    Source sequence(s)
    AC004686, BC053365, BP359158, CA444907
    Consensus CDS
    CCDS62271.1
    UniProtKB/Swiss-Prot
    P23443
    Related
    ENSP00000384335.3, ENST00000406116.7
    Conserved Domains (1) summary
    cd05584
    Location:94 → 416
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  3. NM_001272044.2 → NP_001258973.1  ribosomal protein S6 kinase beta-1 isoform d

    See identical proteins and their annotated locations for NP_001258973.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' region, and initiates translation at the third in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC004686, AK297147, BP359158, CA444907
    Consensus CDS
    CCDS62273.1
    UniProtKB/Swiss-Prot
    P23443
    Related
    ENSP00000376744.3, ENST00000393021.7
    Conserved Domains (1) summary
    cd05584
    Location:41 → 363
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  4. NM_001272060.2 → NP_001258989.1  ribosomal protein S6 kinase beta-1 isoform e

    See identical proteins and their annotated locations for NP_001258989.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) can initiate translation from two alternate in-frame AUG start codons. The isoform represented in this RefSeq (e, also known as p70 or alpha II) is derived from the second AUG start codon, and is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC004686, AK297147, AK312875, BP359158, CA444907
    UniProtKB/Swiss-Prot
    P23443
    Conserved Domains (2) summary
    smart00220
    Location:68 → 329
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05584
    Location:71 → 393
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  5. NM_001369669.1 → NP_001356598.1  ribosomal protein S6 kinase beta-1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cd05584
    Location:94 → 380
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  6. NM_001369670.1 → NP_001356599.1  ribosomal protein S6 kinase beta-1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cd05584
    Location:41 → 342
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  7. NM_001369671.1 → NP_001356600.1  ribosomal protein S6 kinase beta-1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cd05584
    Location:48 → 336
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  8. NM_001369672.1 → NP_001356601.1  ribosomal protein S6 kinase beta-1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cd05584
    Location:41 → 327
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

  9. NM_001369673.1 → NP_001356602.1  ribosomal protein S6 kinase beta-1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cl21453
    Location:41 → 142
    PKc_like; Protein Kinases, catalytic domain

  10. NM_001369674.1 → NP_001356603.1  ribosomal protein S6 kinase beta-1 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variant 11, encodes isoform k.
    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cl21453
    Location:94 → 210
    PKc_like; Protein Kinases, catalytic domain

  11. NM_001369675.1 → NP_001356604.1  ribosomal protein S6 kinase beta-1 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 10, encodes isoform k.
    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cl21453
    Location:94 → 210
    PKc_like; Protein Kinases, catalytic domain

  12. NM_001369676.1 → NP_001356605.1  ribosomal protein S6 kinase beta-1 isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 13-15, encodes isoform l.
    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cl21453
    Location:94 → 195
    PKc_like; Protein Kinases, catalytic domain

  13. NM_001369677.1 → NP_001356606.1  ribosomal protein S6 kinase beta-1 isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 12, 14, and 15, encodes isoform l.
    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cl21453
    Location:94 → 195
    PKc_like; Protein Kinases, catalytic domain

  14. NM_001369678.1 → NP_001356607.1  ribosomal protein S6 kinase beta-1 isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 12, 13, and 15, encodes isoform l.
    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cl21453
    Location:94 → 195
    PKc_like; Protein Kinases, catalytic domain

  15. NM_001369679.1 → NP_001356608.1  ribosomal protein S6 kinase beta-1 isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 12-14, encodes isoform l.
    Source sequence(s)
    AC004686
    Conserved Domains (1) summary
    cl21453
    Location:94 → 195
    PKc_like; Protein Kinases, catalytic domain

  16. NM_003161.4 → NP_003152.1  ribosomal protein S6 kinase beta-1 isoform a

    See identical proteins and their annotated locations for NP_003152.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) can initiate translation from two alternate in-frame AUG start codons. The isoform represented in this RefSeq (a, also known as p85 or alpha I) is derived from the first AUG start codon, and is the longest isoform.
    Source sequence(s)
    AC004686, AK297147, AK312875, BP359158, CA444907
    Consensus CDS
    CCDS11621.1
    UniProtKB/Swiss-Prot
    P23443
    Related
    ENSP00000225577.4, ENST00000225577.9
    Conserved Domains (1) summary
    cd05584
    Location:94 → 416
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

RNA

  1. NR_161455.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004686

  2. NR_161456.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004686

  3. NR_161457.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004686

  4. NR_161458.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004686

  5. NR_161459.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004686

  6. NR_161460.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004686

  7. NR_161461.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004686

  8. NR_161462.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004686

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    59893121..59950574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525102.3 → XP_011523404.1  ribosomal protein S6 kinase beta-1 isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:91 → 352
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05584
    Location:94 → 378
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

RNA

  1. XR_002958051.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23443.2 GenPept UniProtKB/Swiss-Prot:P23443

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