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Faim2 Fas apoptotic inhibitory molecule 2 [ Mus musculus (house mouse) ]

Gene ID: 72393, updated on 5-Mar-2024

Summary

Official Symbol
Faim2provided by MGI
Official Full Name
Fas apoptotic inhibitory molecule 2provided by MGI
Primary source
MGI:MGI:1919643
See related
Ensembl:ENSMUSG00000023011 AllianceGenome:MGI:1919643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lfg; Lfg2; NMP25; Nmp35; Tmbim2; 2900002L20Rik
Summary
Involved in cerebellar Purkinje cell differentiation; cerebellar granular layer development; and regulation of neuron apoptotic process. Acts upstream of or within negative regulation of apoptotic signaling pathway; negative regulation of neuron apoptotic process; and response to ischemia. Located in Golgi apparatus; endoplasmic reticulum; and membrane raft. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and white fat. Orthologous to human FAIM2 (Fas apoptotic inhibitory molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 23.5), frontal lobe adult (RPKM 16.4) and 5 other tissues See more
Orthologs
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Genomic context

Location:
15 F1; 15 56.13 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99394886..99432757, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99497005..99534880, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene NCK-associated protein 5-like Neighboring gene NCK-associated protein 5-like, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E5516 Neighboring gene BCDIN3 domain containing Neighboring gene predicted gene 5808 Neighboring gene STARR-seq mESC enhancer starr_39713 Neighboring gene predicted gene, 34765 Neighboring gene aquaporin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebellar Purkinje cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebellar Purkinje cell layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebellar granular layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein lifeguard 2
Names
neural membrane protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038658.2NP_001033747.1  protein lifeguard 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK030513, AK158960, BC072560, CJ283203
    Consensus CDS
    CCDS88840.1
    UniProtKB/Swiss-Prot
    Q8K097
    Related
    ENSMUSP00000155195.2, ENSMUST00000231171.2
    Conserved Domains (1) summary
    cd10428
    Location:81301
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
  2. NM_028224.4NP_082500.2  protein lifeguard 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK030513, AK158960, BC072560, CJ283203
    Consensus CDS
    CCDS37203.1
    UniProtKB/Swiss-Prot
    Q3TY22, Q8K097, Q8K1F6, Q9D6K4
    Related
    ENSMUSP00000023750.8, ENSMUST00000023750.9
    Conserved Domains (1) summary
    cd10428
    Location:93313
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99394886..99432757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521449.5XP_006521512.1  protein lifeguard 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3TY22, Q8K097, Q8K1F6, Q9D6K4
    Conserved Domains (1) summary
    cd10428
    Location:93313
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis