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FAIM2 Fas apoptotic inhibitory molecule 2 [ Homo sapiens (human) ]

Gene ID: 23017, updated on 8-Oct-2017
Official Symbol
FAIM2provided by HGNC
Official Full Name
Fas apoptotic inhibitory molecule 2provided by HGNC
Primary source
HGNC:HGNC:17067
See related
Ensembl:ENSG00000135472 MIM:604306; Vega:OTTHUMG00000169808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LFG; LFG2; NGP35; NMP35; TMBIM2
Orthologs
Location:
12q13.12
Exon count:
14
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (49866896..49904275, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (50260679..50297760, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene BCDIN3D antisense RNA 1 Neighboring gene BCDIN3 domain containing RNA methyltransferase Neighboring gene ribosomal protein L35a pseudogene 28 Neighboring gene long intergenic non-protein coding RNA 2396 Neighboring gene long intergenic non-protein coding RNA 2395

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
NHGRI GWA Catalog
Genome-wide association study of obsessive-compulsive disorder.
NHGRI GWA Catalog
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
NHGRI GWA Catalog
NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0950

Gene Ontology Provided by GOA

Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cerebellar Purkinje cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cerebellar Purkinje cell layer development ISS
Inferred from Sequence or Structural Similarity
more info
 
cerebellar granular layer development ISS
Inferred from Sequence or Structural Similarity
more info
 
cerebellum development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ischemia IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein lifeguard 2
Names
neural membrane protein 35
transmembrane BAX inhibitor motif-containing protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012306.3NP_036438.2  protein lifeguard 2

    See identical proteins and their annotated locations for NP_036438.2

    Status: VALIDATED

    Source sequence(s)
    AC131157, BC000051
    Consensus CDS
    CCDS8791.1
    UniProtKB/Swiss-Prot
    Q9BWQ8
    Related
    ENSP00000321951.3, OTTHUMP00000242156, ENST00000320634.7, OTTHUMT00000405984
    Conserved Domains (1) summary
    cd10428
    Location:92312
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

    Range
    49866896..49904275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019040.1XP_016874529.1  protein lifeguard 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9BWQ8
    Conserved Domains (1) summary
    cd10428
    Location:92312
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
  2. XM_005268730.3XP_005268787.1  protein lifeguard 2 isoform X2

    Related
    ENSP00000446771.1, OTTHUMP00000242570, ENST00000552669.5, OTTHUMT00000405987
    Conserved Domains (1) summary
    cd10428
    Location:50270
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    50227016..50263951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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