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FAIM2 Fas apoptotic inhibitory molecule 2 [ Homo sapiens (human) ]

Gene ID: 23017, updated on 22-Sep-2022

Summary

Official Symbol
FAIM2provided by HGNC
Official Full Name
Fas apoptotic inhibitory molecule 2provided by HGNC
Primary source
HGNC:HGNC:17067
See related
Ensembl:ENSG00000135472 MIM:604306; AllianceGenome:HGNC:17067
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LFG; LFG2; NGP35; NMP35; TMBIM2
Summary
Involved in regulation of neuron apoptotic process. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in membrane raft. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 125.6) and adrenal (RPKM 12.3) See more
Orthologs
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Genomic context

See FAIM2 in Genome Data Viewer
Location:
12q13.12
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (49866896..49903900, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (49829908..49866914, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (50260679..50297683, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene BCDIN3D antisense RNA 1 Neighboring gene BCDIN3 domain containing RNA methyltransferase Neighboring gene ribosomal protein L35a pseudogene 28 Neighboring gene long intergenic non-protein coding RNA 2396 Neighboring gene long intergenic non-protein coding RNA 2395

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
EBI GWAS Catalog
Genome-wide association study of obsessive-compulsive disorder.
EBI GWAS Catalog
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
EBI GWAS Catalog
NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0950

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebellar Purkinje cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cerebellar Purkinje cell layer development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cerebellar granular layer development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cerebellum development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ischemia IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein lifeguard 2
Names
neural membrane protein 35
transmembrane BAX inhibitor motif-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012306.4NP_036438.2  protein lifeguard 2

    See identical proteins and their annotated locations for NP_036438.2

    Status: VALIDATED

    Source sequence(s)
    AC131157, BC000051
    Consensus CDS
    CCDS8791.1
    UniProtKB/Swiss-Prot
    Q9BWQ8, Q9Y2F7
    Related
    ENSP00000321951.3, ENST00000320634.8
    Conserved Domains (1) summary
    cd10428
    Location:92312
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    49866896..49903900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268730.4XP_005268787.1  protein lifeguard 2 isoform X1

    Related
    ENSP00000446771.1, ENST00000552669.5
    Conserved Domains (1) summary
    cd10428
    Location:50270
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    49829908..49866914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)