Format

Send to:

Choose Destination

TRPC3 transient receptor potential cation channel subfamily C member 3 [ Homo sapiens (human) ]

Gene ID: 7222, updated on 20-Sep-2020

Summary

Official Symbol
TRPC3provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily C member 3provided by HGNC
Primary source
HGNC:HGNC:12335
See related
Ensembl:ENSG00000138741 MIM:602345
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRP3; SCA41
Summary
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See TRPC3 in Genome Data Viewer
Location:
4q27
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (121874481..121952060, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (122800183..122872909, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene exosome component 9 Neighboring gene cyclin A2 Neighboring gene Bardet-Biedl syndrome 7 Neighboring gene uncharacterized LOC102724158 Neighboring gene Sharpr-MPRA regulatory region 11420 Neighboring gene uncharacterized LOC112268469

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel activity TAS
Traceable Author Statement
more info
PubMed 
inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol 1,4,5 trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
calcium ion transport TAS
Traceable Author Statement
more info
PubMed 
manganese ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phototransduction TAS
Traceable Author Statement
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of calcium ion transport into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiac muscle hypertrophy in response to stress IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to ATP IDA
Inferred from Direct Assay
more info
PubMed 
response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
short transient receptor potential channel 3
Names
hTrp-3
transient receptor potential cation channel subfamily C member 3 variant c
transient receptor protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030368.1 RefSeqGene

    Range
    5001..77727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130698.2NP_001124170.1  short transient receptor potential channel 3 isoform a

    See identical proteins and their annotated locations for NP_001124170.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC079341, AC108930, AY865574, Y13758
    Consensus CDS
    CCDS47130.1
    UniProtKB/Swiss-Prot
    Q13507
    Related
    ENSP00000368966.3, ENST00000379645.8
    Conserved Domains (4) summary
    cd00204
    Location:119253
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:96890
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:267326
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:146177
    ANK; ANK repeat [structural motif]
  2. NM_001366479.2NP_001353408.1  short transient receptor potential channel 3 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC079341, AC108930
    Conserved Domains (2) summary
    TIGR00870
    Location:96862
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:146177
    ANK; ANK repeat [structural motif]
  3. NM_003305.2NP_003296.1  short transient receptor potential channel 3 isoform b

    See identical proteins and their annotated locations for NP_003296.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an upstream exon , compared to variant 1, resulting in a different 5' UTR and 5' coding region and translation initiation from an inframe, downstream ATG. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AY865574, Y13758
    Consensus CDS
    CCDS3725.1
    UniProtKB/Swiss-Prot
    Q13507
    Related
    ENSP00000264811.5, ENST00000264811.9
    Conserved Domains (2) summary
    TIGR00870
    Location:23817
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:73104
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    121874481..121952060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532218.3XP_011530520.1  short transient receptor potential channel 3 isoform X3

    Conserved Domains (4) summary
    cd00204
    Location:119253
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:96889
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:267326
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:146177
    ANK; ANK repeat [structural motif]
  2. XM_017008578.2XP_016864067.1  short transient receptor potential channel 3 isoform X2

  3. XM_011532217.3XP_011530519.1  short transient receptor potential channel 3 isoform X1

    Conserved Domains (4) summary
    cd00204
    Location:119253
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:96906
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:267326
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:146177
    ANK; ANK repeat [structural motif]
Support Center