Trpc3 transient receptor potential cation channel, subfamily C, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trpc3provided by MGI
Official Full Name: transient receptor potential cation channel, subfamily C, member 3provided by MGI
Primary source: MGI:MGI:109526
See related: Ensembl:ENSMUSG00000027716 AllianceGenome:MGI:109526
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mwk; Trp3; Trcp3; Trrp3
Summary: Predicted to enable calcium activated cation channel activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Predicted to be involved in several processes, including metal ion transport; positive regulation of cardiac muscle hypertrophy in response to stress; and response to ATP. Predicted to act upstream of or within calcium ion transport. Predicted to be located in plasma membrane. Predicted to be part of cation channel complex. Predicted to be integral component of plasma membrane. Is expressed in cochlea; ganglia; limb; spinal cord; and trunk somite. Human ortholog(s) of this gene implicated in cerebellar ataxia type 41. Orthologous to human TRPC3 (transient receptor potential cation channel subfamily C member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 16.9), CNS E18 (RPKM 4.1) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 B; 3 17.93 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (36674631..36744577, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (36620482..36690429, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sensory neuron-expressed TRPC3 mediates acute and chronic itch.
Title: Sensory neuron-expressed TRPC3 mediates acute and chronic itch.
TRPC3 Regulates Islet Beta-Cell Insulin Secretion.
Title: TRPC3 Regulates Islet Beta-Cell Insulin Secretion.
Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells.
Title: Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells.
Increase in membrane surface expression and phosphorylation of TRPC3 related to olfactory dysfunction in alpha-synuclein transgenic mice.
Title: Increase in membrane surface expression and phosphorylation of TRPC3 related to olfactory dysfunction in α-synuclein transgenic mice.
Sodium-Glucose Cotransporter 2 Inhibitor Canagliflozin Antagonizes Salt-Sensitive Hypertension Through Modifying Transient Receptor Potential Channels 3 Mediated Vascular Calcium Handling.
Title: Sodium-Glucose Cotransporter 2 Inhibitor Canagliflozin Antagonizes Salt-Sensitive Hypertension Through Modifying Transient Receptor Potential Channels 3 Mediated Vascular Calcium Handling.
A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia.
Title: A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia.
TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons.
Title: TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons.
Isoproterenol-induced hypertrophy of neonatal cardiac myocytes and H9c2 cell is dependent on TRPC3-regulated CaV1.2 expression.
Title: Isoproterenol-induced hypertrophy of neonatal cardiac myocytes and H9c2 cell is dependent on TRPC3-regulated Ca(V)1.2 expression.
A Selective TRPC3 Inhibitor Pyr3 Attenuates Myocardial Ischemia/Reperfusion Injury in Mice.
Title: A Selective TRPC3 Inhibitor Pyr3 Attenuates Myocardial Ischemia/Reperfusion Injury in Mice.
Implication of TRPC3 channel in gustatory perception of dietary lipids.
Title: Implication of TRPC3 channel in gustatory perception of dietary lipids.

Submit: New GeneRIF Correction See all GeneRIFs (87)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trpc3 (e-PCR), detects polymorphism
- UniSTS:546049

Trpc3 (e-PCR), detects polymorphism
- UniSTS:531240

Trrp3 (e-PCR), detects polymorphism
- UniSTS:144684

Trpc3 (e-PCR), detects polymorphism
- UniSTS:516713

Trpc3 (e-PCR), detects polymorphism
- UniSTS:516714

Homology

Homologs of the Trpc3 gene: The Trpc3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 373 organisms have orthologs with human gene Trpc3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables inositol 1,4,5 trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in response to ATP	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in single fertilization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: short transient receptor potential channel 3

Names: TRP-3; mTrp3; receptor-activated cation channel TRP3; transient receptor protein 3; trp-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403842.1 → NP_001390771.1 short transient receptor potential channel 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC117584
NM_019510.3 → NP_062383.2 short transient receptor potential channel 3 isoform 1

See identical proteins and their annotated locations for NP_062383.2

Status: VALIDATED

Source sequence(s)

AC117584

Consensus CDS

CCDS50893.1

UniProtKB/Swiss-Prot

Q61058

UniProtKB/TrEMBL

A0A8C6MTW8, B1ATV3, Q8BNT8, Q8CCQ1

Related

ENSMUSP00000029271.5, ENSMUST00000029271.5

Conserved Domains (4) summary

cd00204
Location:108 → 242

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:85 → 879

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:256 → 315

TRP_2; Transient receptor ion channel II

sd00045
Location:135 → 166

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

36674631..36744577 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535439.5 → XP_006535502.1 short transient receptor potential channel 3 isoform X1

Conserved Domains (2) summary

TIGR00870
Location:85 → 851

trp; transient-receptor-potential calcium channel protein

sd00045
Location:135 → 166

ANK; ANK repeat [structural motif]