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Trpc3 transient receptor potential cation channel, subfamily C, member 3 [ Mus musculus (house mouse) ]

Gene ID: 22065, updated on 2-Nov-2024

Summary

Official Symbol
Trpc3provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily C, member 3provided by MGI
Primary source
MGI:MGI:109526
See related
Ensembl:ENSMUSG00000027716 AllianceGenome:MGI:109526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mwk; Trp3; Trcp3; Trrp3
Summary
Predicted to enable calcium-activated cation channel activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Predicted to be involved in several processes, including positive regulation of calcium ion transport into cytosol; positive regulation of cardiac muscle hypertrophy in response to stress; and response to ATP. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cochlea; ganglia; skeletal muscle; spinal cord; and trunk somite. Human ortholog(s) of this gene implicated in cerebellar ataxia type 41. Orthologous to human TRPC3 (transient receptor potential cation channel subfamily C member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 16.9), CNS E18 (RPKM 4.1) and 11 other tissues See more
Orthologs
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Genomic context

See Trpc3 in Genome Data Viewer
Location:
3 B; 3 17.93 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (36674626..36744276, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (36620482..36690429, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2068 Neighboring gene exosome component 9 Neighboring gene STARR-seq mESC enhancer starr_07426 Neighboring gene cyclin A2 Neighboring gene Bardet-Biedl syndrome 7 Neighboring gene predicted gene, 35856 Neighboring gene STARR-seq mESC enhancer starr_07428 Neighboring gene protein tyrosine phosphatase, mitochondrial 1 pseudogene Neighboring gene bridge-like lipid transfer protein family member 1 Neighboring gene STARR-seq mESC enhancer starr_07429 Neighboring gene STARR-seq mESC enhancer starr_07431

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC124333

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-activated cation channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inositol 1,4,5 trisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables inositol 1,4,5 trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion transport into cytosol IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle hypertrophy in response to stress IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardiac muscle hypertrophy in response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to ATP IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ATP ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
short transient receptor potential channel 3
Names
TRP-3
mTrp3
receptor-activated cation channel TRP3
transient receptor protein 3
trp-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403842.1NP_001390771.1  short transient receptor potential channel 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117584
  2. NM_019510.3NP_062383.2  short transient receptor potential channel 3 isoform 1

    See identical proteins and their annotated locations for NP_062383.2

    Status: VALIDATED

    Source sequence(s)
    AC117584
    Consensus CDS
    CCDS50893.1
    UniProtKB/Swiss-Prot
    B1ATV3, Q61058, Q9QZC1
    UniProtKB/TrEMBL
    Q8CCQ1
    Related
    ENSMUSP00000029271.5, ENSMUST00000029271.5
    Conserved Domains (4) summary
    cd00204
    Location:108242
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:85879
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:256315
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:135166
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    36674626..36744276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)