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Fbxl2 F-box and leucine-rich repeat protein 2 [ Mus musculus (house mouse) ]

Gene ID: 72179, updated on 9-Dec-2022

Summary

Official Symbol
Fbxl2provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 2provided by MGI
Primary source
MGI:MGI:1919429
See related
Ensembl:ENSMUSG00000032507 AllianceGenome:MGI:1919429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbl3; 2810423A21Rik
Summary
Predicted to enable phosphatidylinositol 3-kinase regulatory subunit binding activity and protein phosphatase binding activity. Acts upstream of or within protein monoubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in dorsal root ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Orthologous to human FBXL2 (F-box and leucine rich repeat protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 11.6), CNS E18 (RPKM 10.1) and 24 other tissues See more
Orthologs
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Genomic context

See Fbxl2 in Genome Data Viewer
Location:
9; 9 F3
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (113787625..113855871, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (113958557..114026803, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CLIP associating protein 2 Neighboring gene predicted gene, 25059 Neighboring gene predicted gene, 39439 Neighboring gene upstream binding protein 1 Neighboring gene predicted gene, 36035 Neighboring gene predicted gene, 36883 Neighboring gene sushi domain containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol 3-kinase regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178624.6NP_848739.1  F-box/LRR-repeat protein 2

    See identical proteins and their annotated locations for NP_848739.1

    Status: VALIDATED

    Source sequence(s)
    AK039010, AK141177
    Consensus CDS
    CCDS40790.1
    UniProtKB/Swiss-Prot
    Q8BH16, Q8BXM4
    UniProtKB/TrEMBL
    Q4VA21
    Related
    ENSMUSP00000035090.8, ENSMUST00000035090.14
    Conserved Domains (3) summary
    cd09293
    Location:168367
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:106131
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:1557
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    113787625..113855871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244622.1XP_030100482.1  F-box/LRR-repeat protein 2 isoform X3

    Conserved Domains (2) summary
    cd09293
    Location:63262
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:2752
    LRR_AMN1; leucine-rich repeat [structural motif]
  2. XM_030244623.2XP_030100483.1  F-box/LRR-repeat protein 2 isoform X3

    Conserved Domains (2) summary
    cd09293
    Location:63262
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:2752
    LRR_AMN1; leucine-rich repeat [structural motif]
  3. XM_011243027.3XP_011241329.1  F-box/LRR-repeat protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011241329.1

    Conserved Domains (2) summary
    cd09293
    Location:63262
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:2752
    LRR_AMN1; leucine-rich repeat [structural motif]
  4. XM_036155307.1XP_036011200.1  F-box/LRR-repeat protein 2 isoform X2

    Conserved Domains (3) summary
    cd09293
    Location:80275
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:106131
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:1556
    F-box-like
  5. XM_036155306.1XP_036011199.1  F-box/LRR-repeat protein 2 isoform X1

    Conserved Domains (3) summary
    cd09293
    Location:80275
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:5279
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:1556
    F-box-like
  6. XM_006512295.3XP_006512358.1  F-box/LRR-repeat protein 2 isoform X4

    Conserved Domains (3) summary
    cd09293
    Location:80275
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:5279
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:1556
    F-box-like

RNA

  1. XR_379878.4 RNA Sequence

  2. XR_003948012.2 RNA Sequence

  3. XR_379879.3 RNA Sequence

  4. XR_379880.5 RNA Sequence

  5. XR_004935563.1 RNA Sequence

    Related
    ENSMUST00000143180.8
  6. XR_003948011.2 RNA Sequence