Format

Send to:

Choose Destination

FBXL2 F-box and leucine rich repeat protein 2 [ Homo sapiens (human) ]

Gene ID: 25827, updated on 3-May-2020

Summary

Official Symbol
FBXL2provided by HGNC
Official Full Name
F-box and leucine rich repeat protein 2provided by HGNC
Primary source
HGNC:HGNC:13598
See related
Ensembl:ENSG00000153558 MIM:605652
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBL2; FBL3
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Expression
Broad expression in brain (RPKM 5.0), testis (RPKM 4.2) and 22 other tissues See more
Orthologs

Genomic context

See FBXL2 in Genome Data Viewer
Location:
3p22.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (33277025..33422698)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (33318934..33445505)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene cartilage associated protein Neighboring gene sushi domain containing 5 Neighboring gene RNA, U7 small nuclear 110 pseudogene Neighboring gene upstream binding protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 128 Neighboring gene cytoplasmic linker associated protein 2 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564P0622

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase regulatory subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
modulation by host of viral RNA genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein monoubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis TAS
Traceable Author Statement
more info
PubMed 
regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
F-box/LRR-repeat protein 2
Names
F-box protein FBL2/FBL3
F-box protein containing leucine-rich repeats

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001349316.2NP_001336245.1  F-box/LRR-repeat protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AC122176, AC123900
    Conserved Domains (3) summary
    sd00034
    Location:106131
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:1556
    F-box-like; F-box-like
    cl28166
    Location:168398
    AMN1; Antagonist of mitotic exit network protein 1
  2. NM_001349319.1NP_001336248.1  F-box/LRR-repeat protein 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform 4.
    Source sequence(s)
    AC122176, AC123900
    Conserved Domains (2) summary
    sd00034
    Location:2752
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:63293
    AMN1; Antagonist of mitotic exit network protein 1
  3. NM_001349320.2NP_001336249.1  F-box/LRR-repeat protein 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform 4.
    Source sequence(s)
    AC122176, AC123900
    Conserved Domains (2) summary
    sd00034
    Location:2752
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:63293
    AMN1; Antagonist of mitotic exit network protein 1
  4. NM_001349321.2NP_001336250.1  F-box/LRR-repeat protein 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform 4.
    Source sequence(s)
    AC122176, AC123900
    Conserved Domains (2) summary
    sd00034
    Location:2752
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:63293
    AMN1; Antagonist of mitotic exit network protein 1
  5. NM_001349322.2NP_001336251.1  F-box/LRR-repeat protein 2 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) encodes isoform 5.
    Source sequence(s)
    AC122176, AC123900
    Conserved Domains (2) summary
    sd00034
    Location:2247
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:84283
    AMN1; Antagonist of mitotic exit network protein 1
  6. NM_001349323.1NP_001336252.1  F-box/LRR-repeat protein 2 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 9, 10, and 11, encodes isoform 6.
    Source sequence(s)
    AC122176, AC123900
    Conserved Domains (2) summary
    sd00034
    Location:2752
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:63262
    AMN1; Antagonist of mitotic exit network protein 1
  7. NM_001349324.2NP_001336253.1  F-box/LRR-repeat protein 2 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 8, 10, and 11, encodes isoform 6.
    Source sequence(s)
    AC122176, AC123900
    Conserved Domains (2) summary
    sd00034
    Location:2752
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:63262
    AMN1; Antagonist of mitotic exit network protein 1
  8. NM_001349325.2NP_001336254.1  F-box/LRR-repeat protein 2 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 8, 9, and 11, encodes isoform 6.
    Source sequence(s)
    AC122176, AC123900
    Conserved Domains (2) summary
    sd00034
    Location:2752
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:63262
    AMN1; Antagonist of mitotic exit network protein 1
  9. NM_001349326.2NP_001336255.1  F-box/LRR-repeat protein 2 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 8, 9, and 10, encodes isoform 6.
    Source sequence(s)
    AC122176, AC123900
    Conserved Domains (2) summary
    sd00034
    Location:2752
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:63262
    AMN1; Antagonist of mitotic exit network protein 1
  10. NM_012157.5NP_036289.3  F-box/LRR-repeat protein 2 isoform 1

    See identical proteins and their annotated locations for NP_036289.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC122176, AK001271
    Consensus CDS
    CCDS2658.1
    UniProtKB/Swiss-Prot
    Q9UKC9
    Related
    ENSP00000417601.1, ENST00000484457.6
    Conserved Domains (3) summary
    sd00034
    Location:106131
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:1556
    F-box-like; F-box-like
    cl28166
    Location:168367
    AMN1; Antagonist of mitotic exit network protein 1

RNA

  1. NR_146121.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC122176, AC123900
  2. NR_146122.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC122176, AC123900
  3. NR_146123.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC122176, AC123900
  4. NR_146124.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC122176, AC123900
  5. NR_146125.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC122176, AC123900
  6. NR_146126.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC122176, AC123900
  7. NR_146127.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC122176, AC123900
  8. NR_146128.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC122176, AC123900
    Related
    ENST00000463736.5
  9. NR_146129.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC122176, AC123900
  10. NR_146130.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC122176, AC123900
  11. NR_146131.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC122176, AC123900
  12. NR_146132.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC122176, AC123900
  13. NR_146133.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC122176, AC123900
  14. NR_146134.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC122176, AC123900
  15. NR_146135.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC122176, AC123900

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    33277025..33422698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453440.1XP_024309208.1  F-box/LRR-repeat protein 2 isoform X1

    Conserved Domains (3) summary
    sd00034
    Location:106131
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:1556
    F-box-like; F-box-like
    cl28166
    Location:168398
    AMN1; Antagonist of mitotic exit network protein 1
  2. XM_017006093.1XP_016861582.1  F-box/LRR-repeat protein 2 isoform X2

    Related
    ENST00000283627.10
    Conserved Domains (2) summary
    sd00034
    Location:2752
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:63293
    AMN1; Antagonist of mitotic exit network protein 1
  3. XM_005265015.3XP_005265072.1  F-box/LRR-repeat protein 2 isoform X2

    See identical proteins and their annotated locations for XP_005265072.1

    Conserved Domains (2) summary
    sd00034
    Location:2752
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:63293
    AMN1; Antagonist of mitotic exit network protein 1
  4. XM_011533559.2XP_011531861.1  F-box/LRR-repeat protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011531861.1

    Conserved Domains (2) summary
    sd00034
    Location:2752
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:63293
    AMN1; Antagonist of mitotic exit network protein 1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001171713.2: Suppressed sequence

    Description
    NM_001171713.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Support Center