Trim29 tripartite motif-containing 29 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim29provided by MGI
Official Full Name: tripartite motif-containing 29provided by MGI
Primary source: MGI:MGI:1919419
See related: Ensembl:ENSMUSG00000032013 AllianceGenome:MGI:1919419
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110047J21Rik; 2810431N19Rik; 4732461M22Rik
Summary: Enables p53 binding activity. Acts upstream of or within negative regulation of protein localization to nucleus and negative regulation of transcription by RNA polymerase II. Located in cytoplasm. Is expressed in alimentary system; sensory organ; skin; and urethra. Orthologous to human TRIM29 (tripartite motif containing 29). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 26.2), bladder adult (RPKM 22.9) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9; 9 A5.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (43222012..43247422)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (43310715..43336125)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduced Tripartite Motif-Containing Protein 29 Deteriorates the Severity of Severe Acute Pancreatitis.
Title: Reduced Tripartite Motif-Containing Protein 29 Deteriorates the Severity of Severe Acute Pancreatitis.
results identify TRIM29 as a negative regulator of NK cell functions
Title: Identification of the E3 Ligase TRIM29 as a Critical Checkpoint Regulator of NK Cell Functions.
deletion of the Atdc (Trim29) gene, whose human homolog is upregulated in the majority of pancreatic adenocarcinoma, prevents pancreatic adenocarcinoma development in the context of oncogenic KRAS; findings show ATDC (Trim29) promotes acinar-ductal metaplasia progression to pancreatic intraepithelial neoplasia through activation of beta-catenin signaling and subsequent SOX9 up-regulation
Title: ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis.
TRIM29 regulates negatively the host innate immune response to RNA virus, which could be employed by RNA viruses for viral pathogenesis.
Title: TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus.
Knockdown of tripartite motif-containing 29 protein (TRIM29) enhanced the production of type I interferon in human and mouse dendritic cells by up to fourfold in response to intracellular herpes simplex virus.
Title: TRIM29 promotes DNA virus infections by inhibiting innate immune response.
this study shows that deletion of TRIM29 enhanced macrophage production of type I interferons and protected mice from infection with influenza virus, while challenge of Trim29-/- mice with Haemophilus influenzae resulted in lethal lung inflammation due to massive production of proinflammatory cytokines by macrophages
Title: Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract.
Findings established a role for ATDC/TRIM29 as a robust pathogenic driver of bladder cancer development, identified downstream effector pathways, and implicated ATDC as a candidate biomarker and therapeutic target.
Title: ATDC/TRIM29 Drives Invasive Bladder Cancer Formation through miRNA-Mediated and Epigenetic Mechanisms.
ATDC up-regulates CD44 in mouse and human PanIN lesions via activation of beta-catenin signaling, leading to the induction of an epithelial-to-mesenchymal transition (EMT) phenotype characterized by expression of Zeb1 and Snail1.
Title: ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis.
Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein
Title: Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein.
ATDC increases cell proliferation via inhibition of p53 nuclear activities.
Title: The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Trim29 gene: The Trim29 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 348 organisms have orthologs with human gene Trim29
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tripartite motif-containing protein 29

Names: tripartite motif protein 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023655.2 → NP_076144.2 tripartite motif-containing protein 29

See identical proteins and their annotated locations for NP_076144.2

Status: VALIDATED

Source sequence(s)

AC167973, AK013219, AK028448, BB612224

Consensus CDS

CCDS52775.1

UniProtKB/Swiss-Prot

Q8R2Q0, Q9CSC9

Related

ENSMUSP00000034511.6, ENSMUST00000034511.7

Conserved Domains (2) summary

pfam00643
Location:221 → 260

zf-B_box; B-box zinc finger

pfam03993
Location:310 → 372

DUF349; Domain of Unknown Function (DUF349)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

43222012..43247422

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510616.5 → XP_006510679.1 tripartite motif-containing protein 29 isoform X1

See identical proteins and their annotated locations for XP_006510679.1

Conserved Domains (3) summary

pfam01442
Location:275 → 372

Apolipoprotein; Apolipoprotein A1/A4/E domain

cd19769
Location:223 → 260

Bbox2_TRIM16-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM16, TRIM29, TRIM47 and similar proteins

cd19840
Location:171 → 217

Bbox1_TRIM29; B-box-type 1 zinc finger found in tripartite motif-containing protein 29 (TRIM29) and similar proteins
XM_006510617.5 → XP_006510680.1 tripartite motif-containing protein 29 isoform X2

Conserved Domains (3) summary

pfam01442
Location:275 → 372

Apolipoprotein; Apolipoprotein A1/A4/E domain

cd19769
Location:223 → 260

Bbox2_TRIM16-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM16, TRIM29, TRIM47 and similar proteins

cd19840
Location:171 → 217

Bbox1_TRIM29; B-box-type 1 zinc finger found in tripartite motif-containing protein 29 (TRIM29) and similar proteins