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TRIM29 tripartite motif containing 29 [ Homo sapiens (human) ]

Gene ID: 23650, updated on 8-Jul-2018
Official Symbol
TRIM29provided by HGNC
Official Full Name
tripartite motif containing 29provided by HGNC
Primary source
HGNC:HGNC:17274
See related
Ensembl:ENSG00000137699 MIM:610658; Vega:OTTHUMG00000140377
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATDC
Summary
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 274.4), skin (RPKM 264.0) and 4 other tissues See more
Orthologs
See TRIM29 in Genome Data Viewer
Location:
11q23.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (120111275..120138155, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (119981994..120056237, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369527 Neighboring gene uncharacterized LOC105378956 Neighboring gene uncharacterized LOC105369529 Neighboring gene uncharacterized LOC107984399 Neighboring gene uncharacterized LOC105369530

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke.
NHGRI GWA Catalog
Genetic variants near PDGFRA are associated with corneal curvature in Australians.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of tripartite motif containing 29 (TRIM29) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Hematopoietic Stem Cell Differentiation, organism-specific biosystem (from WikiPathways)
    Hematopoietic Stem Cell Differentiation, organism-specific biosystemGrowth factors and miRNA regulating differentiation of hematopoietic stem cells (HSC) to various blood-related cell types. Note that myeloblasts branch off separately from erythrocytes and megakaryoc...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
    Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ36085

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
cadherin binding involved in cell-cell adhesion HDA PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
p53 binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell-cell adherens junction HDA PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tripartite motif-containing protein 29
Names
ataxia-telangiectasia group D-associated protein
tripartite motif protein TRIM29

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330382.1NP_001317311.1  tripartite motif-containing protein 29 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK299459, AP001360, BM996078, CU450129, DC420658
    Consensus CDS
    CCDS81637.1
    UniProtKB/TrEMBL
    B7Z5V5, E9PRL4
    Related
    ENSP00000436015.1, ENST00000529044.5
  2. NM_012101.3NP_036233.2  tripartite motif-containing protein 29 isoform 1

    See identical proteins and their annotated locations for NP_036233.2

    Status: REVIEWED

    Source sequence(s)
    AP000679, BC017352
    Consensus CDS
    CCDS8428.1
    UniProtKB/Swiss-Prot
    Q14134
    UniProtKB/TrEMBL
    A0A024R3J1
    Related
    ENSP00000343129.5, OTTHUMP00000179137, ENST00000341846.9, OTTHUMT00000277108
    Conserved Domains (2) summary
    smart00336
    Location:220260
    BBOX; B-Box-type zinc finger
    cl27218
    Location:273355
    OmpH; Outer membrane protein (OmpH-like)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    120111275..120138155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017453.1XP_016872942.1  tripartite motif-containing protein 29 isoform X1

  2. XM_005271490.1XP_005271547.1  tripartite motif-containing protein 29 isoform X3

    See identical proteins and their annotated locations for XP_005271547.1

    UniProtKB/TrEMBL
    B7Z8U9
    Conserved Domains (1) summary
    pfam01442
    Location:1107
    Apolipoprotein; Apolipoprotein A1/A4/E domain
  3. XM_011542733.1XP_011541035.1  tripartite motif-containing protein 29 isoform X2

    Conserved Domains (1) summary
    cl02488
    Location:2099
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_058193.1: Suppressed sequence

    Description
    NM_058193.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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