U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tmco6 transmembrane and coiled-coil domains 6 [ Mus musculus (house mouse) ]

Gene ID: 71983, updated on 5-Mar-2024

Summary

Official Symbol
Tmco6provided by MGI
Official Full Name
transmembrane and coiled-coil domains 6provided by MGI
Primary source
MGI:MGI:1919233
See related
Ensembl:ENSMUSG00000006850 AllianceGenome:MGI:1919233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410015B03Rik
Summary
Predicted to enable nuclear import signal receptor activity. Predicted to be involved in protein import into nucleus. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human TMCO6 (transmembrane and coiled-coil domains 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 10.8), thymus adult (RPKM 10.8) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tmco6 in Genome Data Viewer
Location:
18 B2; 18 19.46 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36868072..36875453)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36735019..36742400)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44297 Neighboring gene predicted gene, 41699 Neighboring gene CD14 antigen Neighboring gene STARR-positive B cell enhancer ABC_E2505 Neighboring gene STARR-positive B cell enhancer ABC_E8709 Neighboring gene STARR-positive B cell enhancer ABC_E617 Neighboring gene NADH:ubiquinone oxidoreductase subunit A2 Neighboring gene IK cytokine Neighboring gene WD repeat domain 55 Neighboring gene DND microRNA-mediated repression inhibitor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane and coiled-coil domain-containing protein 6

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028036.3NP_082312.3  transmembrane and coiled-coil domain-containing protein 6

    See identical proteins and their annotated locations for NP_082312.3

    Status: VALIDATED

    Source sequence(s)
    AC027740, AK010487, AK046207, BF468256
    Consensus CDS
    CCDS37772.1
    UniProtKB/Swiss-Prot
    Q8BQX5, Q99JV8, Q9CWP3
    Related
    ENSMUSP00000007046.8, ENSMUST00000007046.9
    Conserved Domains (3) summary
    COG5064
    Location:23391
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:104218
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00043
    Location:104135
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    36868072..36875453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250612.1XP_030106472.1  transmembrane and coiled-coil domain-containing protein 6 isoform X2

  2. XM_006526276.4XP_006526339.1  transmembrane and coiled-coil domain-containing protein 6 isoform X1

    Conserved Domains (2) summary
    COG5064
    Location:43315
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:2959
    ARM; armadillo repeat [structural motif]