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Nkiras2 NFKB inhibitor interacting Ras-like protein 2 [ Mus musculus (house mouse) ]

Gene ID: 71966, updated on 29-Oct-2022

Summary

Official Symbol
Nkiras2provided by MGI
Official Full Name
NFKB inhibitor interacting Ras-like protein 2provided by MGI
Primary source
MGI:MGI:1919216
See related
Ensembl:ENSMUSG00000017837 AllianceGenome:MGI:1919216
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KBRAS2; 2410003M04Rik; 4930527H08Rik; D630018G21Rik
Summary
Enables GTPase activating protein binding activity. Acts upstream of or within several processes, including Ral protein signal transduction; regulation of signal transduction; and surfactant homeostasis. Predicted to be located in cytoplasm. Is expressed in cerebral cortex; dorsal root ganglion; and nose. Orthologous to human NKIRAS2 (NFKB inhibitor interacting Ras like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 90.6), colon adult (RPKM 42.0) and 27 other tissues See more
Orthologs
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Genomic context

See Nkiras2 in Genome Data Viewer
Location:
11; 11 D
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100510007..100518436)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100619181..100627610)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene outer dynein arm complex subunit 4 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 11 C17orf113 homolog Neighboring gene predicted gene, 38483 Neighboring gene DEXH (Asp-Glu-X-His) box polypeptide 58

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activating protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NF-kappa-B inhibitor-interacting Ras-like protein 2
Names
I-kappa-B-interacting Ras-like protein 2
kappa B-Ras protein 2
kappaB-Ras2
NP_082300.1
XP_030102201.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028024.2NP_082300.1  NF-kappa-B inhibitor-interacting Ras-like protein 2

    See identical proteins and their annotated locations for NP_082300.1

    Status: PROVISIONAL

    Source sequence(s)
    AL591469
    Consensus CDS
    CCDS25429.1
    UniProtKB/Swiss-Prot
    Q8BWG0, Q9CR56
    UniProtKB/TrEMBL
    A0A8C6GF22
    Related
    ENSMUSP00000017981.4, ENSMUST00000017981.10
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100510007..100518436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246341.1XP_030102201.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BWG0
    UniProtKB/TrEMBL
    A0A8C6GF22
    Related
    ENSMUSP00000059559.4, ENSMUST00000051947.10
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases