Format

Send to:

Choose Destination

NKIRAS2 NFKB inhibitor interacting Ras like 2 [ Homo sapiens (human) ]

Gene ID: 28511, updated on 7-Oct-2018

Summary

Official Symbol
NKIRAS2provided by HGNC
Official Full Name
NFKB inhibitor interacting Ras like 2provided by HGNC
Primary source
HGNC:HGNC:17898
See related
Ensembl:ENSG00000168256 MIM:604497; Vega:OTTHUMG00000133503
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KBRAS2; kappaB-Ras2
Expression
Ubiquitous expression in placenta (RPKM 30.4), esophagus (RPKM 22.7) and 25 other tissues See more
Orthologs

Genomic context

See NKIRAS2 in Genome Data Viewer
Location:
17q21.2
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (42017576..42025641)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40169594..40177659)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 25 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 17 open reading frame 113 Neighboring gene DExH-box helicase 58

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC74742, DKFZp434N1526

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NF-kappa-B inhibitor-interacting Ras-like protein 2
Names
I-kappa-B-interacting Ras-like protein 2
NFKB inhibitor interacting Ras-like protein 2
kappa B-Ras protein 2
NP_001001349.1
NP_001138399.1
NP_001138400.1
NP_001138401.1
NP_060065.2
XP_005257308.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001349.2NP_001001349.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a

    See identical proteins and their annotated locations for NP_001001349.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1-3 encode the same protein (isoform a).
    Source sequence(s)
    AC105024, BC063498
    Consensus CDS
    CCDS11415.1
    UniProtKB/Swiss-Prot
    Q9NYR9
    UniProtKB/TrEMBL
    A0A024R1Z4
    Related
    ENSP00000303580.5, OTTHUMP00000164768, ENST00000307641.9, OTTHUMT00000257457
    Conserved Domains (1) summary
    cl21455
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001144927.1NP_001138399.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a

    See identical proteins and their annotated locations for NP_001138399.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform a. Variants 1-3 encode the same protein (isoform a).
    Source sequence(s)
    AC105024, BC063498, BG717103, DA607452
    Consensus CDS
    CCDS11415.1
    UniProtKB/Swiss-Prot
    Q9NYR9
    UniProtKB/TrEMBL
    A0A024R1Z4
    Related
    ENSP00000377459.3, OTTHUMP00000164765, ENST00000393881.7, OTTHUMT00000257450
    Conserved Domains (1) summary
    cl21455
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_001144928.1NP_001138400.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform b

    See identical proteins and their annotated locations for NP_001138400.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1. These differences result in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC105024, AK297975, BC063498, BG717103
    Consensus CDS
    CCDS45679.1
    UniProtKB/Swiss-Prot
    Q9NYR9
    Related
    ENSP00000401976.4, OTTHUMP00000164766, ENST00000449471.8, OTTHUMT00000257453
    Conserved Domains (1) summary
    cl21455
    Location:6112
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001144929.1NP_001138401.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform c

    See identical proteins and their annotated locations for NP_001138401.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks a segment of the coding region, compared to variant 1. These differences result in a shorter protein (isoform c) with a novel C-terminus, compared to isoform a.
    Source sequence(s)
    AC105024, BC063498, BG717103, DA509824
    Consensus CDS
    CCDS45680.1
    UniProtKB/Swiss-Prot
    Q9NYR9
    Related
    ENSP00000465633.1, OTTHUMP00000263345, ENST00000479407.5, OTTHUMT00000257454
    Conserved Domains (1) summary
    cd00882
    Location:852
    Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
  5. NM_017595.5NP_060065.2  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a

    See identical proteins and their annotated locations for NP_060065.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes isoform a. Variants 1-3 encode the same protein (isoform a).
    Source sequence(s)
    AC105024, BC007316, BC063498, BG717103
    Consensus CDS
    CCDS11415.1
    UniProtKB/Swiss-Prot
    Q9NYR9
    UniProtKB/TrEMBL
    A0A024R1Z4
    Related
    ENSP00000377463.3, OTTHUMP00000164763, ENST00000393885.8, OTTHUMT00000257448
    Conserved Domains (1) summary
    cl21455
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    42017576..42025641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257251.1XP_005257308.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005257308.1

    UniProtKB/Swiss-Prot
    Q9NYR9
    UniProtKB/TrEMBL
    A0A024R1Z4
    Related
    ENSP00000377458.1, OTTHUMP00000164764, ENST00000393880.5, OTTHUMT00000257449
    Conserved Domains (1) summary
    cl21455
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Support Center