Gpc2 glypican 2 (cerebroglycan) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpc2provided by MGI
Official Full Name: glypican 2 (cerebroglycan)provided by MGI
Primary source: MGI:MGI:1919201
See related: Ensembl:ENSMUSG00000029510 AllianceGenome:MGI:1919201
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2410016G05Rik
Summary: Predicted to be involved in several processes, including positive regulation of neuron projection development; regulation of protein localization to membrane; and smoothened signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in cell surface and synapse. Is expressed in several structures, including branchial arch; lower jaw; nervous system; reproductive system; and sensory organ. Orthologous to human GPC2 (glypican 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E14 (RPKM 130.8), whole brain E14.5 (RPKM 125.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5; 5 G2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (138271918..138278288, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (138273657..138280026, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gpc2 is enriched in neurogenic regions of the adult brain. Its expression is increased by physiological stimuli that increase hippocampal neurogenesis and decreased in transgenic models in which neurogenesis is selectively ablated. Changes in neurogenesis also result in changes in Gpc2 protein level in cerebrospinal fluid (CSF).
Title: Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Gpc2 (e-PCR), detects polymorphism
- UniSTS:466039

Homology

Homologs of the Gpc2 gene: The Gpc2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs from Annotation Pipeline: 222 organisms have orthologs with human gene Gpc2

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi lumen	TAS Traceable Author Statement more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: glypican-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417777.1 → NP_001404706.1 glypican-2 isoform 2

Status: VALIDATED

Source sequence(s)

AC159257
NM_172412.3 → NP_766000.1 glypican-2 isoform 1 precursor

See identical proteins and their annotated locations for NP_766000.1

Status: VALIDATED

Source sequence(s)

AC159257

Consensus CDS

CCDS19799.1

UniProtKB/Swiss-Prot

Q8BKV1

Related

ENSMUSP00000124459.2, ENSMUST00000161827.8

Conserved Domains (1) summary

pfam01153
Location:20 → 559

Glypican; Glypican

RNA

NR_184575.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC159257

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

138271918..138278288 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165503.1 → XP_036021396.1 glypican-2 isoform X2

Conserved Domains (1) summary

pfam01153
Location:1 → 305

Glypican
XM_006504623.4 → XP_006504686.1 glypican-2 isoform X1

Conserved Domains (1) summary

pfam01153
Location:2 → 424

Glypican
XM_006504624.3 → XP_006504687.1 glypican-2 isoform X2

Related

ENSMUST00000159689.8

Conserved Domains (1) summary

pfam01153
Location:1 → 305

Glypican
XM_036165502.1 → XP_036021395.1 glypican-2 isoform X1

Conserved Domains (1) summary

pfam01153
Location:2 → 424

Glypican
XM_030254816.2 → XP_030110676.1 glypican-2 isoform X3

Conserved Domains (1) summary

pfam01153
Location:9 → 325

Glypican