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GPC2 glypican 2 [ Homo sapiens (human) ]

Gene ID: 221914, updated on 8-Jul-2021

Summary

Official Symbol
GPC2provided by HGNC
Official Full Name
glypican 2provided by HGNC
Primary source
HGNC:HGNC:4450
See related
Ensembl:ENSG00000213420 MIM:618446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 5.5), skin (RPKM 2.9) and 7 other tissues See more
Orthologs
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Genomic context

See GPC2 in Genome Data Viewer
Location:
7q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100169606..100177381, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99767229..99775004, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 14 Neighboring gene microRNA 4658 Neighboring gene galactose-3-O-sulfotransferase 4 Neighboring gene 60S ribosomal protein L29-like Neighboring gene stromal antigen 3 Neighboring gene CASTOR family member 3 Neighboring gene PVR related immunoglobulin domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ38962, DKFZp547M109

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
 
located_in anchored component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal lumen TAS
Traceable Author Statement
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glypican-2
Names
cerebroglycan proteoglycan
glypican proteoglycan 2, cerebroglycan proteoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152742.3NP_689955.1  glypican-2 precursor

    See identical proteins and their annotated locations for NP_689955.1

    Status: VALIDATED

    Source sequence(s)
    AI863264, AK096281, BC027972, HY045249
    Consensus CDS
    CCDS5689.1
    UniProtKB/Swiss-Prot
    Q8N158
    Related
    ENSP00000292377.2, ENST00000292377.4
    Conserved Domains (1) summary
    pfam01153
    Location:29512
    Glypican; Glypican

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100169606..100177381 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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