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C3AR1 complement C3a receptor 1 [ Homo sapiens (human) ]

Gene ID: 719, updated on 3-May-2020

Summary

Official Symbol
C3AR1provided by HGNC
Official Full Name
complement C3a receptor 1provided by HGNC
Primary source
HGNC:HGNC:1319
See related
Ensembl:ENSG00000171860 MIM:605246
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AZ3B; C3AR; HNFAG09
Summary
C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016]
Expression
Broad expression in appendix (RPKM 43.3), placenta (RPKM 19.2) and 21 other tissues See more
Orthologs

Genomic context

See C3AR1 in Genome Data Viewer
Location:
12p13.31
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (8056844..8066359, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (8210919..8218955, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene Neighboring gene forkhead box J2 Neighboring gene NECAP endocytosis associated 1 Neighboring gene C-type lectin domain family 4 member A Neighboring gene POU class 5 homeobox 1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates the gene expression of C3AR1 in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
complement component C3a receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
complement component C3a receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
complement receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
blood circulation TAS
Traceable Author Statement
more info
PubMed 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
complement receptor mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
positive regulation of macrophage chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular endothelial growth factor production IEA
Inferred from Electronic Annotation
more info
 
regulation of complement activation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
azurophil granule membrane TAS
Traceable Author Statement
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
C3a anaphylatoxin chemotactic receptor
Names
complement component 3 receptor 1
complement component 3a receptor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050736.1 RefSeqGene

    Range
    5113..14628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001326475.2NP_001313404.1  C3a anaphylatoxin chemotactic receptor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC006511, BU074964, DB274838
    Consensus CDS
    CCDS8588.1
    UniProtKB/Swiss-Prot
    Q16581
    UniProtKB/TrEMBL
    A8K2H7
    Conserved Domains (1) summary
    cd15115
    Location:24446
    7tmA_C3aR; complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001326477.2NP_001313406.1  C3a anaphylatoxin chemotactic receptor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC006511, BU074964, DA351375, DB013722
    Consensus CDS
    CCDS8588.1
    UniProtKB/Swiss-Prot
    Q16581
    UniProtKB/TrEMBL
    A8K2H7
    Conserved Domains (1) summary
    cd15115
    Location:24446
    7tmA_C3aR; complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_004054.4NP_004045.1  C3a anaphylatoxin chemotactic receptor

    See identical proteins and their annotated locations for NP_004045.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. All three variants encode the same protein.
    Source sequence(s)
    AC006511, BC020742, BU074964
    Consensus CDS
    CCDS8588.1
    UniProtKB/Swiss-Prot
    Q16581
    UniProtKB/TrEMBL
    A8K2H7
    Related
    ENSP00000302079.4, ENST00000307637.5
    Conserved Domains (1) summary
    cd15115
    Location:24446
    7tmA_C3aR; complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    8056844..8066359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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