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Dpep3 dipeptidase 3 [ Mus musculus (house mouse) ]

Gene ID: 71854, updated on 1-Mar-2024

Summary

Official Symbol
Dpep3provided by MGI
Official Full Name
dipeptidase 3provided by MGI
Primary source
MGI:MGI:1919104
See related
Ensembl:ENSMUSG00000031898 AllianceGenome:MGI:1919104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MBD-3; MLZ-136; 1700018F16Rik
Summary
Enables dipeptidase activity. Acts upstream of or within proteolysis. Located in acrosomal vesicle and plasma membrane. Is anchored component of membrane. Is expressed in gonad. Orthologous to human DPEP3 (dipeptidase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 252.4) See more
Orthologs
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Genomic context

See Dpep3 in Genome Data Viewer
Location:
8 D3; 8 53.07 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106700152..106706051, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105973520..105979419, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 12, member 4 Neighboring gene lecithin cholesterol acyltransferase Neighboring gene microRNA 7074 Neighboring gene STARR-seq mESC enhancer starr_22546 Neighboring gene predicted gene 45752 Neighboring gene dipeptidase 2 Neighboring gene predicted gene, 22972 Neighboring gene DEAD box helicase 28 Neighboring gene dihydrouridine synthase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables dipeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables dipeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metallodipeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dipeptidase 3
Names
membrane-bound dipeptidase 3
protein expressed in male leptotene and zygotene spermatocytes 136
putative membrane-bound dipeptidase 3
NP_082236.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027960.2NP_082236.1  dipeptidase 3 precursor

    See identical proteins and their annotated locations for NP_082236.1

    Status: VALIDATED

    Source sequence(s)
    AK006085
    Consensus CDS
    CCDS22624.1
    UniProtKB/Swiss-Prot
    Q9DA79
    Related
    ENSMUSP00000034371.8, ENSMUST00000034371.9
    Conserved Domains (1) summary
    pfam01244
    Location:83404
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106700152..106706051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)