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DPEP3 dipeptidase 3 [ Homo sapiens (human) ]

Gene ID: 64180, updated on 23-Nov-2021


Official Symbol
DPEP3provided by HGNC
Official Full Name
dipeptidase 3provided by HGNC
Primary source
See related
Ensembl:ENSG00000141096 MIM:609926
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family. Alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Restricted expression toward testis (RPKM 28.2) See more
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Genomic context

See DPEP3 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (67975663..67980499, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68009566..68014402, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit beta 10 Neighboring gene lecithin-cholesterol acyltransferase Neighboring gene solute carrier family 12 member 4 Neighboring gene dipeptidase 2 Neighboring gene lysyl-tRNA synthetase 1 pseudogene 3

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show downregulation of dipeptidase 3 (DPEP3) expression as compared to untreated control PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dipeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
enables metallodipeptidase activity IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
located_in acrosomal vesicle ISS
Inferred from Sequence or Structural Similarity
more info
located_in anchored component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info

General protein information

Preferred Names
dipeptidase 3
membrane-bound dipeptidase 3
metallopeptidase (family M19)
testis secretory sperm-binding protein Li 211a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129758.2NP_001123230.2  dipeptidase 3 isoform b precursor

    Status: REVIEWED

    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the mid-coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter, compared to isoform a.
    Source sequence(s)
    Conserved Domains (1) summary
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  2. NM_001370198.1NP_001357127.1  dipeptidase 3 isoform c precursor

    Status: REVIEWED

    Source sequence(s)
    AK057401, AY358390
    Consensus CDS
    ENSP00000268793.5, ENST00000268793.6
    Conserved Domains (1) summary
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    67975663..67980499 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022357.4: Suppressed sequence

    NM_022357.4: This RefSeq was removed because currently there is support for the transcript but not for the protein.
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