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TRAF1 TNF receptor associated factor 1 [ Homo sapiens (human) ]

Gene ID: 7185, updated on 11-Jun-2021

Summary

Official Symbol
TRAF1provided by HGNC
Official Full Name
TNF receptor associated factor 1provided by HGNC
Primary source
HGNC:HGNC:12031
See related
Ensembl:ENSG00000056558 MIM:601711
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EBI6; MGC:10353
Summary
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Expression
Broad expression in lymph node (RPKM 17.6), appendix (RPKM 12.6) and 24 other tissues See more
Orthologs
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Genomic context

See TRAF1 in Genome Data Viewer
Location:
9q33.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (120902393..120929171, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (123664671..123691449, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory regions 2033 and 13781 Neighboring gene cutA divalent cation tolerance like, pseudogene Neighboring gene PHD finger protein 19 Neighboring gene CRISPRi-validated cis-regulatory element chr9.2278 Neighboring gene C5 3' UTR overlapping transcript 1 Neighboring gene complement C5 Neighboring gene centriolin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
GeneReviews: Not available
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
GeneReviews: Not available
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
GeneReviews: Not available
Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans.
GeneReviews: Not available
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
GeneReviews: Not available
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of TNF receptor-associated factor 1 (TRAF1) in Vif-expression T cells PubMed
Vpr vpr HIV-1 Vpr-mediated CASP8 (caspase 8) activation is mediated by TRAF-1 in THP-1 cells PubMed
Vpu vpu Levels of TRAF1 are reduced in T cells as a result of HIV-1 Vpu-mediated inhibition of NF-kappa B activation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thioesterase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tumor necrosis factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tumor necrosis factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of plasma membrane signaling receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
TNF receptor-associated factor 1
Names
Epstein-Bar virus-induced protein 6
NP_001177874.1
NP_001177876.1
NP_005649.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023346.1 RefSeqGene

    Range
    5001..31781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001190945.2NP_001177874.1  TNF receptor-associated factor 1 isoform a

    See identical proteins and their annotated locations for NP_001177874.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to isoform 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC006430, AK315476, U19261
    Consensus CDS
    CCDS6825.1
    UniProtKB/Swiss-Prot
    Q13077
    Related
    ENSP00000443183.1, ENST00000540010.1
    Conserved Domains (3) summary
    cd03779
    Location:267413
    MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam16673
    Location:184244
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
    cl25732
    Location:140263
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001190947.2NP_001177876.1  TNF receptor-associated factor 1 isoform b

    See identical proteins and their annotated locations for NP_001177876.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC006430, AK295959, U19261
    Consensus CDS
    CCDS55335.1
    UniProtKB/Swiss-Prot
    Q13077
    Related
    ENSP00000438583.1, ENST00000546084.5
    Conserved Domains (2) summary
    cd03779
    Location:145291
    MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam16673
    Location:62122
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
  3. NM_005658.5NP_005649.1  TNF receptor-associated factor 1 isoform a

    See identical proteins and their annotated locations for NP_005649.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC006430, AK315476, AL832989, U19261
    Consensus CDS
    CCDS6825.1
    UniProtKB/Swiss-Prot
    Q13077
    Related
    ENSP00000362994.3, ENST00000373887.8
    Conserved Domains (3) summary
    cd03779
    Location:267413
    MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam16673
    Location:184244
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
    cl25732
    Location:140263
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    120902393..120929171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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