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Kif23 kinesin family member 23 [ Mus musculus (house mouse) ]

Gene ID: 71819, updated on 18-Apr-2024

Summary

Official Symbol
Kif23provided by MGI
Official Full Name
kinesin family member 23provided by MGI
Primary source
MGI:MGI:1919069
See related
Ensembl:ENSMUSG00000032254 AllianceGenome:MGI:1919069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHO1; Knsl5; MKLP1; MKLP-1; 3110001D19Rik
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in several processes, including mitotic cytokinesis; mitotic spindle midzone assembly; and positive regulation of cytokinesis. Predicted to act upstream of or within cell division. Located in intercellular bridge. Is expressed in several structures, including alimentary system; hindbrain; nephrogenic zone; olfactory epithelium; and ventricular layer. Orthologous to human KIF23 (kinesin family member 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 14.9), liver E14 (RPKM 11.3) and 13 other tissues See more
Orthologs
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Genomic context

Location:
9 B; 9 33.5 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (61824559..61854078, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (61917277..61946810, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6748 Neighboring gene predicted gene, 35058 Neighboring gene ribosomal protein lateral stalk subunit P1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:61794519-61794820 Neighboring gene STARR-positive B cell enhancer mm9_chr9:61795876-61796177 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:61808677-61808878 Neighboring gene STARR-positive B cell enhancer ABC_E5075 Neighboring gene progestin and adipoQ receptor family member V Neighboring gene predicted gene, 35152 Neighboring gene glucuronyl C5-epimerase Neighboring gene microRNA 5133

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic spindle midzone assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Flemming body ISO
Inferred from Sequence Orthology
more info
 
part_of centralspindlin complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kinesin-like protein KIF23
Names
kinesin-like 5 (mitotic kinesin-like protein 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405055.1NP_001391984.1  kinesin-like protein KIF23 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC151969
  2. NM_001405056.1NP_001391985.1  kinesin-like protein KIF23 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC151969
  3. NM_001405057.1NP_001391986.1  kinesin-like protein KIF23 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC151969
  4. NM_024245.5NP_077207.3  kinesin-like protein KIF23 isoform 2

    See identical proteins and their annotated locations for NP_077207.3

    Status: VALIDATED

    Source sequence(s)
    AC151969
    Consensus CDS
    CCDS40662.1
    UniProtKB/Swiss-Prot
    E9Q5G3, Q80V30, Q99PT8
    Related
    ENSMUSP00000034815.8, ENSMUST00000034815.9
    Conserved Domains (4) summary
    cd01368
    Location:24434
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam00225
    Location:31436
    Kinesin; Kinesin motor domain
    pfam08702
    Location:498603
    Fib_alpha; Fibrinogen alpha/beta chain family
    pfam16540
    Location:797896
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    61824559..61854078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244618.2XP_030100478.1  kinesin-like protein KIF23 isoform X4

    Conserved Domains (3) summary
    pfam05483
    Location:504690
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    cd01368
    Location:24448
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam16540
    Location:707809
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
  2. XM_006511453.5XP_006511516.1  kinesin-like protein KIF23 isoform X2

    Conserved Domains (3) summary
    pfam05483
    Location:504690
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    cd01368
    Location:24448
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam16540
    Location:811913
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1