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KIF23 kinesin family member 23 [ Homo sapiens (human) ]

Gene ID: 9493, updated on 24-Nov-2020

Summary

Official Symbol
KIF23provided by HGNC
Official Full Name
kinesin family member 23provided by HGNC
Primary source
HGNC:HGNC:6392
See related
Ensembl:ENSG00000137807 MIM:605064
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHO1; KNSL5; MKLP1; MKLP-1
Summary
The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Broad expression in bone marrow (RPKM 9.3), testis (RPKM 8.0) and 17 other tissues See more
Orthologs

Genomic context

See KIF23 in Genome Data Viewer
Location:
15q23
Exon count:
25
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (69414325..69448427)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69706585..69740766)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene PAQR5 divergent transcript Neighboring gene progestin and adipoQ receptor family member 5 Neighboring gene Sharpr-MPRA regulatory region 4882 Neighboring gene uncharacterized LOC145694 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 pseudogene Neighboring gene uncharacterized LOC105370876 Neighboring gene Sharpr-MPRA regulatory region 2 Neighboring gene ribosomal protein lateral stalk subunit P1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actomyosin contractile ring assembly IEA
Inferred from Electronic Annotation
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based movement TAS
Traceable Author Statement
more info
 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle elongation TAS
Traceable Author Statement
more info
PubMed 
mitotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle midzone assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
plus-end-directed vesicle transport along microtubule IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Flemming body IDA
Inferred from Direct Assay
more info
 
centralspindlin complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion HDA PubMed 
intercellular bridge IEA
Inferred from Electronic Annotation
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF23
Names
kinesin-like 5 (mitotic kinesin-like protein 1)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042269.1 RefSeqGene

    Range
    5104..39182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1173

mRNA and Protein(s)

  1. NM_001281301.2NP_001268230.1  kinesin-like protein KIF23 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, initiates translation at an alternate start codon, and has multiple differences in the coding region compared to variant 1. The resulting protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA291944, AC027237, AK308322, BG939827
    Conserved Domains (3) summary
    cl22853
    Location:106324
    Motor_domain; Myosin and Kinesin motor domain
    pfam16540
    Location:683709
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    cl23720
    Location:447505
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. NM_001367804.2NP_001354733.1  kinesin-like protein KIF23 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC027237
  3. NM_001367805.3NP_001354734.1  kinesin-like protein KIF23 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC027237
  4. NM_004856.7NP_004847.2  kinesin-like protein KIF23 isoform 2

    See identical proteins and their annotated locations for NP_004847.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AA291944, AC027237, BC051826, BI093060
    Consensus CDS
    CCDS32279.1
    UniProtKB/Swiss-Prot
    Q02241
    Related
    ENSP00000304978.6, ENST00000352331.8
    Conserved Domains (4) summary
    cd01368
    Location:24434
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam00225
    Location:31436
    Kinesin; Kinesin motor domain
    pfam16540
    Location:700799
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    cl23720
    Location:557615
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  5. NM_138555.4NP_612565.1  kinesin-like protein KIF23 isoform 1

    See identical proteins and their annotated locations for NP_612565.1

    Status: REVIEWED

    Source sequence(s)
    AA291944, AK310402, BC017705, BF541143, BX477359, H63163
    Consensus CDS
    CCDS32278.1
    UniProtKB/Swiss-Prot
    Q02241
    Related
    ENSP00000497065.1, ENST00000647715.1
    Conserved Domains (4) summary
    cd01368
    Location:24434
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam00225
    Location:31436
    Kinesin; Kinesin motor domain
    pfam12329
    Location:538611
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    pfam16540
    Location:804903
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

RNA

  1. NR_160295.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC027237
  2. NR_160296.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC027237

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    69414325..69448427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522238.2XP_011520540.1  kinesin-like protein KIF23 isoform X5

    Conserved Domains (3) summary
    cl22853
    Location:106338
    Motor_domain; Myosin and Kinesin motor domain
    pfam12329
    Location:442515
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    pfam16540
    Location:708807
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
  2. XM_024450110.1XP_024305878.1  kinesin-like protein KIF23 isoform X6

    Conserved Domains (3) summary
    pfam16540
    Location:694796
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    cl22853
    Location:106324
    Motor_domain; Myosin and Kinesin motor domain
    cl25732
    Location:374567
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_005254797.3XP_005254854.1  kinesin-like protein KIF23 isoform X2

    Conserved Domains (4) summary
    smart00129
    Location:25456
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01368
    Location:24448
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam12329
    Location:552625
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    pfam16540
    Location:818917
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
  4. XM_005254798.3XP_005254855.1  kinesin-like protein KIF23 isoform X3

    Conserved Domains (4) summary
    cd01368
    Location:24448
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam00225
    Location:31450
    Kinesin; Kinesin motor domain
    pfam12329
    Location:552625
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    pfam16540
    Location:807833
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
  5. XM_005254799.3XP_005254856.1  kinesin-like protein KIF23 isoform X4

    Related
    ENSP00000453386.2, ENST00000559279.6
    Conserved Domains (4) summary
    cd01368
    Location:24448
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam00225
    Location:31450
    Kinesin; Kinesin motor domain
    pfam16540
    Location:714813
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    cl23720
    Location:571629
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  6. XM_017022733.2XP_016878222.1  kinesin-like protein KIF23 isoform X8

  7. XM_011522239.3XP_011520541.1  kinesin-like protein KIF23 isoform X7

    Conserved Domains (3) summary
    cl22853
    Location:1313
    Motor_domain; Myosin and Kinesin motor domain
    pfam16540
    Location:683782
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    cl23720
    Location:436494
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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