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Mtfr2 mitochondrial fission regulator 2 [ Mus musculus (house mouse) ]

Gene ID: 71804, updated on 5-Mar-2024

Summary

Official Symbol
Mtfr2provided by MGI
Official Full Name
mitochondrial fission regulator 2provided by MGI
Primary source
MGI:MGI:1919054
See related
Ensembl:ENSMUSG00000019992 AllianceGenome:MGI:1919054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dufd1; Fam54a; 2610016C23Rik; 4933412C16Rik
Summary
Involved in aerobic respiration and mitochondrial fission. Located in mitochondrion. Is expressed in liver; seminiferous tubule; spleen; and testis. Orthologous to human MTFR2 (mitochondrial fission regulator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 5.4), liver E14.5 (RPKM 5.1) and 11 other tissues See more
Orthologs
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Genomic context

Location:
10 A3; 10 9.75 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (20223491..20237415)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (20344653..20361669)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25961 Neighboring gene microRNA 6413 Neighboring gene BCL2-associated transcription factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E6822 Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25963 Neighboring gene phosphodiesterase 7B Neighboring gene STARR-seq mESC enhancer starr_25964 Neighboring gene VISTA enhancer mm140 Neighboring gene STARR-positive B cell enhancer ABC_E1796 Neighboring gene F-box protein 34 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial fission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrion organization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial fission regulator 2
Names
DUF729 domain containing 1
DUF729 domain-containing protein 1
family with sequence similarity 54, member A
protein FAM54A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027930.3NP_082206.2  mitochondrial fission regulator 2

    See identical proteins and their annotated locations for NP_082206.2

    Status: VALIDATED

    Source sequence(s)
    AC153845, AK011410
    Consensus CDS
    CCDS48511.1
    UniProtKB/Swiss-Prot
    E9PX02, Q8VED8
    UniProtKB/TrEMBL
    Q9D0I1
    Related
    ENSMUSP00000129315.2, ENSMUST00000169712.3
    Conserved Domains (1) summary
    pfam05308
    Location:42299
    Mito_fiss_reg; Mitochondrial fission regulator

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    20223491..20237415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512858.5XP_006512921.1  mitochondrial fission regulator 2 isoform X1

    See identical proteins and their annotated locations for XP_006512921.1

    UniProtKB/TrEMBL
    Q9D0I1, Q9D456
    Conserved Domains (1) summary
    pfam05308
    Location:25282
    Mito_fiss_reg; Mitochondrial fission regulator