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Marchf8 membrane associated ring-CH-type finger 8 [ Mus musculus (house mouse) ]

Gene ID: 71779, updated on 6-Jun-2024

Summary

Official Symbol
Marchf8provided by MGI
Official Full Name
membrane associated ring-CH-type finger 8provided by MGI
Primary source
MGI:MGI:1919029
See related
Ensembl:ENSMUSG00000025702 AllianceGenome:MGI:1919029
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mir; March8; MARCH-VIII; 1300017E09Rik
Summary
The protein encoded by this gene is a member of the membrane-associated really interesting new gene-CH family of proteins. These proteins are E3 ubiquitin-protein ligases that modulate antigen presentation by downregulating major histocompatibility complex class II surface expression through endocytosis. The transcript is primarily expressed by dendritic cells and macrophages. Overexpression of this gene in antigen presenting cells results in immune defective phenotypes, including resistance to autoimmune disease onset. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in kidney adult (RPKM 18.7), liver E14 (RPKM 18.4) and 28 other tissues See more
Orthologs
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Genomic context

See Marchf8 in Genome Data Viewer
Location:
6 E3; 6 53.78 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (116312546..116386501)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (116337599..116409540)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene WASH complex subunit 2 Neighboring gene predicted gene, 52873 Neighboring gene STARR-positive B cell enhancer ABC_E2799 Neighboring gene zinc finger, AN1-type domain 4 Neighboring gene STARR-seq mESC enhancer starr_17102 Neighboring gene predicted gene, 23527 Neighboring gene predicted gene, 38880 Neighboring gene arachidonate 5-lipoxygenase Neighboring gene olfactory receptor family 13 subfamily A member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables MHC protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MARCHF8
Names
E3 ubiquitin-protein ligase MARCH8
RING-type E3 ubiquitin transferase MARCH8
RING-type E3 ubiquitin transferase MARCHF8
c-mir, cellular modulator of immune recognition
cellular modulator of immune recognition
membrane-associated RING finger protein 8
membrane-associated RING-CH protein VIII
membrane-associated ring finger (C3HC4) 8
NP_001289312.1
NP_001289313.1
NP_001289314.1
NP_001388597.1
NP_001388598.1
NP_001388599.1
NP_001388600.1
NP_001388601.1
NP_001388602.1
NP_082196.1
XP_006506704.1
XP_006506705.1
XP_011239771.1
XP_036008204.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302383.2NP_001289312.1  E3 ubiquitin-protein ligase MARCHF8 isoform 1

    See identical proteins and their annotated locations for NP_001289312.1

    Status: REVIEWED

    Source sequence(s)
    AC123548
    Consensus CDS
    CCDS20451.1
    UniProtKB/Swiss-Prot
    Q9DBD2
    Related
    ENSMUSP00000078024.7, ENSMUST00000079012.13
    Conserved Domains (1) summary
    cd16698
    Location:75126
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  2. NM_001302384.2NP_001289313.1  E3 ubiquitin-protein ligase MARCHF8 isoform 1

    See identical proteins and their annotated locations for NP_001289313.1

    Status: REVIEWED

    Source sequence(s)
    AC123548
    Consensus CDS
    CCDS20451.1
    UniProtKB/Swiss-Prot
    Q9DBD2
    Conserved Domains (1) summary
    cd16698
    Location:75126
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  3. NM_001302385.2NP_001289314.1  E3 ubiquitin-protein ligase MARCHF8 isoform 2

    See identical proteins and their annotated locations for NP_001289314.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC123548
    Consensus CDS
    CCDS85138.1
    UniProtKB/TrEMBL
    A0A0N4SVK0, F6THH9
    Related
    ENSMUSP00000145137.2, ENSMUST00000203193.3
    Conserved Domains (1) summary
    cd16698
    Location:3687
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  4. NM_001401668.1NP_001388597.1  E3 ubiquitin-protein ligase MARCHF8 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC123548
    UniProtKB/TrEMBL
    A0A0N4SV35
    Related
    ENSMUSP00000144936.2, ENSMUST00000123405.8
  5. NM_001401669.1NP_001388598.1  E3 ubiquitin-protein ligase MARCHF8 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC123548
  6. NM_001401670.1NP_001388599.1  E3 ubiquitin-protein ligase MARCHF8 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC123548
    UniProtKB/TrEMBL
    A0A0N4SV35
  7. NM_001401671.1NP_001388600.1  E3 ubiquitin-protein ligase MARCHF8 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC123548
  8. NM_001401672.1NP_001388601.1  E3 ubiquitin-protein ligase MARCHF8 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC123548
    UniProtKB/TrEMBL
    F6THH9
    Related
    ENSMUSP00000115510.3, ENSMUST00000135901.2
  9. NM_001401673.1NP_001388602.1  E3 ubiquitin-protein ligase MARCHF8 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC123548
    UniProtKB/TrEMBL
    A0A0N4SVK0, F6THH9
  10. NM_027920.6NP_082196.1  E3 ubiquitin-protein ligase MARCHF8 isoform 1

    See identical proteins and their annotated locations for NP_082196.1

    Status: REVIEWED

    Source sequence(s)
    AC123548
    Consensus CDS
    CCDS20451.1
    UniProtKB/Swiss-Prot
    Q9DBD2
    Related
    ENSMUSP00000098594.4, ENSMUST00000101032.10
    Conserved Domains (1) summary
    cd16698
    Location:75126
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    116312546..116386501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241469.3XP_011239771.1  E3 ubiquitin-protein ligase MARCHF8 isoform X3

    See identical proteins and their annotated locations for XP_011239771.1

    Conserved Domains (1) summary
    cd16698
    Location:318369
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  2. XM_006506641.5XP_006506704.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

    See identical proteins and their annotated locations for XP_006506704.1

    UniProtKB/TrEMBL
    A0A0N4SV35
    Conserved Domains (1) summary
    cd16698
    Location:357408
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  3. XM_036152311.1XP_036008204.1  E3 ubiquitin-protein ligase MARCHF8 isoform X4

    UniProtKB/Swiss-Prot
    Q9DBD2
    Conserved Domains (1) summary
    cd16698
    Location:75126
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
  4. XM_006506642.2XP_006506705.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

    See identical proteins and their annotated locations for XP_006506705.1

    UniProtKB/TrEMBL
    A0A0N4SV35
    Conserved Domains (1) summary
    cd16698
    Location:357408
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins