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Armcx3 armadillo repeat containing, X-linked 3 [ Mus musculus (house mouse) ]

Gene ID: 71703, updated on 21-Apr-2024

Summary

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Official Symbol
Armcx3provided by MGI
Official Full Name
armadillo repeat containing, X-linked 3provided by MGI
Primary source
MGI:MGI:1918953
See related
Ensembl:ENSMUSG00000049047 AllianceGenome:MGI:1918953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ALEX3; 1200004E24Rik
Summary
Acts upstream of or within several processes, including axonal transport of mitochondrion; mitochondrion organization; and positive regulation of transcription by RNA polymerase II. Located in cytosol; mitochondrion; and nucleus. Is integral component of mitochondrial outer membrane. Is expressed in central nervous system; jaw bone; testis mesenchyme; and tongue. Orthologous to human ARMCX3 (armadillo repeat containing X-linked 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 12.0), limb E14.5 (RPKM 11.2) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X E3; X 56.25 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (133657301..133662206)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134756552..134761457)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing, X-linked 7, pseudogene Neighboring gene armadillo repeat containing, X-linked 6 Neighboring gene microRNA 7093 Neighboring gene STARR-seq mESC enhancer starr_47969 Neighboring gene armadillo repeat containing, X-linked 2 Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The armadillo-repeat containing X-linked protein 3, ARMCX3, is a negative regulator of the browning of adipose tissue associated with obesity. Gavaldà-Navarro A, et al. Int J Obes (Lond), 2022 Sep. PMID 35705702
  2. DNA microarray analysis of region-specific gene expression in the mouse epididymis. Hsia N, et al. Biol Reprod, 2004 Feb. PMID 14561649
  3. Alex3 suppresses non-small cell lung cancer invasion via AKT/Slug/E-cadherin pathway. Du J, et al. Tumour Biol, 2017 Jul. PMID 28705116
  4. The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10. Mou Z, et al. J Biol Chem, 2009 May 15. PMID 19304657, Free PMC Article
  5. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. López-Doménech G, et al. Nat Commun, 2012 May 8. PMID 22569362

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A mammalian-specific Alex3/Galphaq protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival.
    Title: A mammalian-specific Alex3/Gα(q) protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival.
  2. The armadillo-repeat containing X-linked protein 3, ARMCX3, is a negative regulator of the browning of adipose tissue associated with obesity.
    Title: The armadillo-repeat containing X-linked protein 3, ARMCX3, is a negative regulator of the browning of adipose tissue associated with obesity.
  3. Sox10 is a membrane-associated factor whose transcriptional function is increased by direct interactions with ARMCX3
    Title: The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axonal transport of mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mitochondrion organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
armadillo repeat-containing X-linked protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358520.1 → NP_001345449.1  armadillo repeat-containing X-linked protein 3

    Status: VALIDATED

    Source sequence(s)
    AL772348, CX563636
    Consensus CDS
    CCDS30400.1
    UniProtKB/Swiss-Prot
    A2AKS4, Q8BHS6, Q91VP8, Q9DC32
    Related
    ENSMUSP00000084093.5, ENSMUST00000086880.11
    Conserved Domains (2) summary
    sd00043
    Location:156 → 190
    ARM; armadillo repeat [structural motif]
    pfam04826
    Location:112 → 363
    Arm_2; Armadillo-like

  2. NM_001358521.1 → NP_001345450.1  armadillo repeat-containing X-linked protein 3

    Status: VALIDATED

    Source sequence(s)
    AL772348, BY310567
    Consensus CDS
    CCDS30400.1
    UniProtKB/Swiss-Prot
    A2AKS4, Q8BHS6, Q91VP8, Q9DC32
    Related
    ENSMUSP00000084097.5, ENSMUST00000086884.5
    Conserved Domains (2) summary
    sd00043
    Location:156 → 190
    ARM; armadillo repeat [structural motif]
    pfam04826
    Location:112 → 363
    Arm_2; Armadillo-like

  3. NM_027870.4 → NP_082146.2  armadillo repeat-containing X-linked protein 3

    See identical proteins and their annotated locations for NP_082146.2

    Status: VALIDATED

    Source sequence(s)
    AL772348, BU505969, CJ071609
    Consensus CDS
    CCDS30400.1
    UniProtKB/Swiss-Prot
    A2AKS4, Q8BHS6, Q91VP8, Q9DC32
    Related
    ENSMUSP00000080518.4, ENSMUST00000081834.10
    Conserved Domains (2) summary
    sd00043
    Location:156 → 190
    ARM; armadillo repeat [structural motif]
    pfam04826
    Location:112 → 363
    Arm_2; Armadillo-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    133657301..133662206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318626.2 → XP_017174115.1  armadillo repeat-containing X-linked protein 3 isoform X1

    UniProtKB/Swiss-Prot
    A2AKS4, Q8BHS6, Q91VP8, Q9DC32
    Conserved Domains (2) summary
    sd00043
    Location:156 → 190
    ARM; armadillo repeat [structural motif]
    pfam04826
    Location:112 → 363
    Arm_2; Armadillo-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHS6.1 GenPept UniProtKB/Swiss-Prot:Q8BHS6

Gene LinkOut

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