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ARMCX3 armadillo repeat containing X-linked 3 [ Homo sapiens (human) ]

Gene ID: 51566, updated on 7-Jun-2020

Summary

Official Symbol
ARMCX3provided by HGNC
Official Full Name
armadillo repeat containing X-linked 3provided by HGNC
Primary source
HGNC:HGNC:24065
See related
Ensembl:ENSG00000102401 MIM:300364
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALEX3; GASP6; dJ545K15.2
Summary
This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 17.0), thyroid (RPKM 15.9) and 25 other tissues See more
Orthologs

Genomic context

See ARMCX3 in Genome Data Viewer
Location:
Xq22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (101623130..101631910)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100878117..100882833)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing X-linked 7, pseudogene Neighboring gene armadillo repeat containing X-linked 6 Neighboring gene RNA, U6 small nuclear 30, pseudogene Neighboring gene armadillo repeat containing X-linked 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0443, MGC12199, DKFZp781N1954

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
armadillo repeat-containing X-linked protein 3
Names
1200004E24Rik
ARM protein lost in epithelial cancers on chromosome X 3
arm protein lost in epithelial cancers, X chromosome, 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013222.1 RefSeqGene

    Range
    5022..9714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016607.3NP_057691.1  armadillo repeat-containing X-linked protein 3

    See identical proteins and their annotated locations for NP_057691.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    BC005194, BG035798, BM905704, BX647802
    Consensus CDS
    CCDS14489.1
    UniProtKB/Swiss-Prot
    Q9UH62
    UniProtKB/TrEMBL
    A0A024RCF9
    Related
    ENSP00000340672.4, ENST00000341189.8
    Conserved Domains (2) summary
    sd00043
    Location:156190
    ARM; armadillo repeat [structural motif]
    pfam04826
    Location:112363
    Arm_2; Armadillo-like
  2. NM_177947.3NP_808816.1  armadillo repeat-containing X-linked protein 3

    See identical proteins and their annotated locations for NP_808816.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC234775, BC005194, BG035798, BX647802
    Consensus CDS
    CCDS14489.1
    UniProtKB/Swiss-Prot
    Q9UH62
    UniProtKB/TrEMBL
    A0A024RCF9
    Related
    ENSP00000454483.1, ENST00000471229.7
    Conserved Domains (2) summary
    sd00043
    Location:156190
    ARM; armadillo repeat [structural motif]
    pfam04826
    Location:112363
    Arm_2; Armadillo-like
  3. NM_177948.2NP_808817.1  armadillo repeat-containing X-linked protein 3

    See identical proteins and their annotated locations for NP_808817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1, and represents the shortest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    BC005194, BM905704, BX647802, CA397688
    Consensus CDS
    CCDS14489.1
    UniProtKB/Swiss-Prot
    Q9UH62
    UniProtKB/TrEMBL
    A0A024RCF9
    Related
    ENSP00000439032.1, ENST00000537169.1
    Conserved Domains (2) summary
    sd00043
    Location:156190
    ARM; armadillo repeat [structural motif]
    pfam04826
    Location:112363
    Arm_2; Armadillo-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    101623130..101631910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262141.3XP_005262198.1  armadillo repeat-containing X-linked protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005262198.1

    UniProtKB/Swiss-Prot
    Q9UH62
    UniProtKB/TrEMBL
    A0A024RCF9
    Conserved Domains (2) summary
    sd00043
    Location:156190
    ARM; armadillo repeat [structural motif]
    pfam04826
    Location:112363
    Arm_2; Armadillo-like
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