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TPD52L2 TPD52 like 2 [ Homo sapiens (human) ]

Gene ID: 7165, updated on 13-Mar-2020

Summary

Official Symbol
TPD52L2provided by HGNC
Official Full Name
TPD52 like 2provided by HGNC
Primary source
HGNC:HGNC:12007
See related
Ensembl:ENSG00000101150 MIM:603747
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D54; TPD54
Summary
This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. Expression of this gene may be a marker for breast cancer and acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in esophagus (RPKM 35.6), bone marrow (RPKM 34.4) and 25 other tissues See more
Orthologs

Genomic context

See TPD52L2 in Genome Data Viewer
Location:
20q13.33
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (63865228..63891545)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62496581..62522898)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene chromosome 20 open reading frame 181 Neighboring gene uncharacterized LOC112268269 Neighboring gene abhydrolase domain containing 16B Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 Neighboring gene RNA, U1 small nuclear 134, pseudogene Neighboring gene microRNA 941-1 Neighboring gene microRNA 941-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686A1765

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tumor protein D54
Names
HCCR-binding protein 2
tumor protein D52 like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029863.1 RefSeqGene

    Range
    5043..31311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243891.2NP_001230820.1  tumor protein D54 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site and lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (g) is shorter than isoform a.
    Source sequence(s)
    AL118506, DA871584, DC428780
    Conserved Domains (1) summary
    pfam04201
    Location:29172
    TPD52; Tumour protein D52 family
  2. NM_001243892.2NP_001230821.1  tumor protein D54 isoform h

    See identical proteins and their annotated locations for NP_001230821.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site and lacks three exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (h) is shorter than isoform a.
    Source sequence(s)
    AL118506, DC362382
    Consensus CDS
    CCDS58785.1
    UniProtKB/Swiss-Prot
    O43399
    Related
    ENSP00000358943.2, ENST00000369927.8
    Conserved Domains (1) summary
    pfam04201
    Location:32154
    TPD52; Tumour protein D52 family
  3. NM_001243894.1NP_001230823.1  tumor protein D54 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks four consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (i) is shorter than isoform a.
    Source sequence(s)
    AL118506, DA689198, DA871584
    Consensus CDS
    CCDS74753.1
    UniProtKB/TrEMBL
    A0A087WZ51
    Related
    ENSP00000482370.1, ENST00000611972.4
    Conserved Domains (1) summary
    pfam04201
    Location:55143
    TPD52; Tumour protein D52 family
  4. NM_001243895.1NP_001230824.1  tumor protein D54 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks three consecutive exons in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (j) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AL118506, DA547106, DA871584
    Consensus CDS
    CCDS74752.1
    UniProtKB/TrEMBL
    A0A087WYR3
    Related
    ENSP00000482024.1, ENST00000615907.4
    Conserved Domains (1) summary
    pfam04201
    Location:55158
    TPD52; Tumour protein D52 family
  5. NM_003288.4NP_003279.2  tumor protein D54 isoform e

    See identical proteins and their annotated locations for NP_003279.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AL118506, BC006804, DA871584
    Consensus CDS
    CCDS13540.1
    UniProtKB/Swiss-Prot
    O43399
    UniProtKB/TrEMBL
    Q6FGS1
    Related
    ENSP00000343547.4, ENST00000346249.8
    Conserved Domains (1) summary
    pfam04201
    Location:55197
    TPD52; tumor protein D52 family
  6. NM_199359.3NP_955391.1  tumor protein D54 isoform f

    See identical proteins and their annotated locations for NP_955391.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks three exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (f) is shorter than isoform a.
    Source sequence(s)
    AK297064, AL118506, DA871584
    Consensus CDS
    CCDS13541.1
    UniProtKB/TrEMBL
    Q68E05
    Related
    ENSP00000343554.5, ENST00000348257.9
    Conserved Domains (1) summary
    pfam04201
    Location:55177
    TPD52; Tumour protein D52 family
  7. NM_199360.3NP_955392.1  tumor protein D54 isoform a

    See identical proteins and their annotated locations for NP_955392.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL118506, BI667351, DA871584
    Consensus CDS
    CCDS13542.1
    UniProtKB/Swiss-Prot
    O43399
    Related
    ENSP00000217121.5, ENST00000217121.9
    Conserved Domains (1) summary
    pfam04201
    Location:55220
    TPD52; Tumour protein D52 family
  8. NM_199361.3NP_955393.1  tumor protein D54 isoform b

    See identical proteins and their annotated locations for NP_955393.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AL118506, BP347669, DA871584
    Consensus CDS
    CCDS13543.1
    UniProtKB/Swiss-Prot
    O43399
    Related
    ENSP00000340006.4, ENST00000351424.8
    Conserved Domains (1) summary
    pfam04201
    Location:55200
    TPD52; Tumour protein D52 family
  9. NM_199362.3NP_955394.1  tumor protein D54 isoform c

    See identical proteins and their annotated locations for NP_955394.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AL118506, BT019631, DA871584
    Consensus CDS
    CCDS13544.1
    UniProtKB/Swiss-Prot
    O43399
    Related
    ENSP00000344647.4, ENST00000352482.8
    Conserved Domains (1) summary
    pfam04201
    Location:55211
    TPD52; Tumour protein D52 family
  10. NM_199363.3NP_955395.1  tumor protein D54 isoform d

    See identical proteins and their annotated locations for NP_955395.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AK055068, AL118506
    Consensus CDS
    CCDS13545.1
    UniProtKB/Swiss-Prot
    O43399
    Related
    ENSP00000351350.4, ENST00000358548.4
    Conserved Domains (1) summary
    pfam04201
    Location:55191
    TPD52; Tumour protein D52 family

RNA

  1. NR_045090.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) uses an alternate splice site and lacks two consecutive exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL118506, BQ948007, DA871584

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    63865228..63891545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529034.3XP_011527336.1  tumor protein D54 isoform X1

    Conserved Domains (1) summary
    pfam04201
    Location:55198
    TPD52; Tumour protein D52 family
  2. XM_011529035.3XP_011527337.1  tumor protein D54 isoform X3

    Conserved Domains (1) summary
    pfam04201
    Location:55175
    TPD52; Tumour protein D52 family
  3. XM_017028038.2XP_016883527.1  tumor protein D54 isoform X2

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