U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ints13 integrator complex subunit 13 [ Mus musculus (house mouse) ]

Gene ID: 71177, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Ints13provided by MGI
Official Full Name
integrator complex subunit 13provided by MGI
Primary source
MGI:MGI:1918427
See related
Ensembl:ENSMUSG00000040250 AllianceGenome:MGI:1918427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asun; Spata30; 4933424B01Rik
Summary
Predicted to be involved in several processes, including centrosome localization; flagellated sperm motility; and regulation of fertilization. Predicted to act upstream of or within mitotic spindle organization and protein localization to nuclear envelope. Located in cytoplasm and nucleus. Is expressed in cerebral cortex subventricular zone and cerebral cortex ventricular layer. Orthologous to human INTS13 (integrator complex subunit 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 16.0), testis adult (RPKM 14.4) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ints13 in Genome Data Viewer
Location:
6 G3; 6 77.7 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (146446253..146479333, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (146549632..146577835, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-triphosphate receptor 2 Neighboring gene STARR-seq mESC enhancer starr_17800 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:146430030-146430213 Neighboring gene predicted gene, 53317 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:146438434-146438668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:146470563-146470746 Neighboring gene STARR-positive B cell enhancer ABC_E10421 Neighboring gene predicted gene, 53316 Neighboring gene FGFR1 oncogene partner 2 Neighboring gene transmembrane 7 superfamily member 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry. Jodoin JN, et al. Mol Biol Cell, 2012 Dec. PMID 23097494, Free PMC Article
  2. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Jodoin JN, et al. Mol Biol Cell, 2013 Sep. PMID 23904267, Free PMC Article
  3. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article
  4. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article
  5. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC28965

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within centrosome localization ISO
Inferred from Sequence Orthology
more info
  
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of fertilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
integrator complex subunit 13
Names
asunder, spermatogenesis regulator
cell cycle regulator Mat89Bb homolog
likely orthologue of H. sapiens chromosome 12 open reading frame 11 (C12orf11)
protein asunder homolog
spermatogenesis associated 30
spermatogenesis-associated protein 30

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362106.1 → NP_001349035.1  integrator complex subunit 13 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC124128
    Conserved Domains (1) summary
    pfam10221
    Location:7 → 698
    DUF2151; Cell cycle and development regulator

  2. NM_001362107.1 → NP_001349036.1  integrator complex subunit 13 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC124128
    Conserved Domains (1) summary
    pfam10221
    Location:7 → 694
    DUF2151; Cell cycle and development regulator

  3. NM_001362108.1 → NP_001349037.1  integrator complex subunit 13 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC124128
    Conserved Domains (1) summary
    pfam10221
    Location:4 → 692
    DUF2151; Cell cycle and development regulator

  4. NM_138757.2 → NP_620096.2  integrator complex subunit 13 isoform 2

    See identical proteins and their annotated locations for NP_620096.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC124128, BE685943, BI986549, BY741532, CD560819, CF167981, CF949591, CK618181
    Consensus CDS
    CCDS39710.1
    UniProtKB/Swiss-Prot
    E9QLV7, Q8QZV7, Q99JT8
    Related
    ENSMUSP00000032427.9, ENSMUST00000032427.15
    Conserved Domains (1) summary
    pfam10221
    Location:4 → 692
    DUF2151; Cell cycle and development regulator

RNA

  1. NR_155292.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC124128

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    146446253..146479333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152306.1 → XP_036008199.1  integrator complex subunit 13 isoform X2

    Conserved Domains (1) summary
    pfam10221
    Location:4 → 692
    DUF2151; Cell cycle and development regulator

  2. XM_030255594.2 → XP_030111454.1  integrator complex subunit 13 isoform X1

    UniProtKB/Swiss-Prot
    E9QLV7, Q8QZV7, Q99JT8
    Conserved Domains (1) summary
    pfam10221
    Location:4 → 692
    DUF2151; Cell cycle and development regulator

RNA

  1. XR_003956254.2 RNA Sequence

  2. XR_004933623.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8QZV7.2 GenPept UniProtKB/Swiss-Prot:Q8QZV7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous