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INTS13 integrator complex subunit 13 [ Homo sapiens (human) ]

Gene ID: 55726, updated on 17-Jun-2019

Summary

Official Symbol
INTS13provided by HGNC
Official Full Name
integrator complex subunit 13provided by HGNC
Primary source
HGNC:HGNC:20174
See related
Ensembl:ENSG00000064102 MIM:615079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASUN; GCT1; NET48; Mat89Bb; SPATA30; C12orf11
Expression
Ubiquitous expression in adrenal (RPKM 8.5), lymph node (RPKM 6.9) and 25 other tissues See more
Orthologs

Genomic context

See INTS13 in Genome Data Viewer
Location:
12p11.23
Exon count:
19
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (26905171..26938338, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (27058112..27091254, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-trisphosphate receptor type 2 Neighboring gene RNA, 5S ribosomal pseudogene 354 Neighboring gene uncharacterized LOC105369706 Neighboring gene enoyl-CoA hydratase domain containing 2 pseudogene Neighboring gene FGFR1 oncogene partner 2 Neighboring gene transmembrane 7 superfamily member 3 Neighboring gene mediator complex subunit 21

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • RNA polymerase II transcribes snRNA genes, organism-specific biosystem (from REACTOME)
    RNA polymerase II transcribes snRNA genes, organism-specific biosystemSmall nuclear RNAs (snRNAs) play key roles in splicing and some of them, specifically the U1 and U2 snRNAs, are encoded by multicopy snRNA gene clusters containing tandem arrays of genes, about 30 in...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10630, FLJ10637

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to nuclear envelope IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of fertilization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
integrator complex subunit 13
Names
asunder, spermatogenesis regulator homolog (Drosphila)
cell cycle regulator Mat89Bb homolog
germ cell tumor 1
protein asunder homolog
sarcoma antigen NY-SAR-95
spermatogenesis associated 30

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018164.3NP_060634.2  integrator complex subunit 13

    See identical proteins and their annotated locations for NP_060634.2

    Status: VALIDATED

    Source sequence(s)
    BC008368, BM684866, DB239903
    Consensus CDS
    CCDS8708.1
    UniProtKB/Swiss-Prot
    Q9NVM9
    Related
    ENSP00000261191.7, ENST00000261191.12
    Conserved Domains (1) summary
    pfam10221
    Location:7690
    DUF2151; Cell cycle and development regulator

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    26905171..26938338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019635.1XP_016875124.1  integrator complex subunit 13 isoform X6

    Conserved Domains (1) summary
    pfam10221
    Location:7633
    DUF2151; Cell cycle and development regulator
  2. XM_011520751.3XP_011519053.1  integrator complex subunit 13 isoform X5

    See identical proteins and their annotated locations for XP_011519053.1

    Conserved Domains (1) summary
    pfam10221
    Location:7639
    DUF2151; Cell cycle and development regulator
  3. XM_011520750.2XP_011519052.1  integrator complex subunit 13 isoform X1

    See identical proteins and their annotated locations for XP_011519052.1

    Conserved Domains (1) summary
    pfam10221
    Location:7696
    DUF2151; Cell cycle and development regulator
  4. XM_017019633.1XP_016875122.1  integrator complex subunit 13 isoform X3

  5. XM_005253422.4XP_005253479.1  integrator complex subunit 13 isoform X6

    See identical proteins and their annotated locations for XP_005253479.1

    Conserved Domains (1) summary
    pfam10221
    Location:7633
    DUF2151; Cell cycle and development regulator
  6. XM_011520752.3XP_011519054.1  integrator complex subunit 13 isoform X7

    Conserved Domains (1) summary
    pfam10221
    Location:7621
    DUF2151; Cell cycle and development regulator
  7. XM_017019636.2XP_016875125.1  integrator complex subunit 13 isoform X8

  8. XM_024449056.1XP_024304824.1  integrator complex subunit 13 isoform X11

    Conserved Domains (1) summary
    pfam10221
    Location:24412
    DUF2151; Cell cycle and development regulator
  9. XM_011520753.2XP_011519055.1  integrator complex subunit 13 isoform X10

    Related
    ENSP00000445645.1, ENST00000538155.5
    Conserved Domains (1) summary
    pfam10221
    Location:26418
    DUF2151; Cell cycle and development regulator
  10. XM_024449055.1XP_024304823.1  integrator complex subunit 13 isoform X9

    Conserved Domains (1) summary
    pfam10221
    Location:7608
    DUF2151; Cell cycle and development regulator
  11. XM_017019632.1XP_016875121.1  integrator complex subunit 13 isoform X2

    UniProtKB/Swiss-Prot
    Q9NVM9
    Conserved Domains (1) summary
    pfam10221
    Location:7690
    DUF2151; Cell cycle and development regulator
  12. XM_017019634.1XP_016875123.1  integrator complex subunit 13 isoform X4

RNA

  1. XR_001748805.2 RNA Sequence

  2. XR_001748804.2 RNA Sequence

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