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TMF1 TATA element modulatory factor 1 [ Homo sapiens (human) ]

Gene ID: 7110, updated on 4-Dec-2022

Summary

Official Symbol
TMF1provided by HGNC
Official Full Name
TATA element modulatory factor 1provided by HGNC
Primary source
HGNC:HGNC:11870
See related
Ensembl:ENSG00000144747 MIM:601126; AllianceGenome:HGNC:11870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMF; ARA160
Summary
Enables androgen receptor binding activity and nuclear receptor coactivator activity. Involved in androgen receptor signaling pathway and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 20.2), thyroid (RPKM 13.7) and 25 other tissues See more
Orthologs
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Genomic context

See TMF1 in Genome Data Viewer
Location:
3p14.1
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (69019827..69052333, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (69056599..69089119, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (69068978..69101484, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 4 Neighboring gene RNA, 5S ribosomal pseudogene 135 Neighboring gene Sharpr-MPRA regulatory region 589 Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene microRNA 3136 Neighboring gene ubiquitin like modifier activating enzyme 3 Neighboring gene ADP ribosylation factor like GTPase 6 interacting protein 5 Neighboring gene leiomodin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear androgen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TATA element modulatory factor
Names
androgen receptor coactivator 160 kDa protein
androgen receptor-associated protein of 160 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363879.1NP_001350808.1  TATA element modulatory factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109587, BC143840, DC401240
    Consensus CDS
    CCDS87105.1
    Related
    ENSP00000494067.1, ENST00000646708.1
    Conserved Domains (2) summary
    pfam12325
    Location:9791090
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
    cl25732
    Location:4571093
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_007114.3NP_009045.2  TATA element modulatory factor isoform 1

    See identical proteins and their annotated locations for NP_009045.2

    Status: VALIDATED

    Source sequence(s)
    AB209109, AC109587, AL040699, BC033771, BU689613
    Consensus CDS
    CCDS43105.1
    UniProtKB/Swiss-Prot
    P82094, Q59GK0
    UniProtKB/TrEMBL
    A0A024R370, Q6PII6
    Related
    ENSP00000381567.2, ENST00000398559.7
    Conserved Domains (5) summary
    COG4942
    Location:698939
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    pfam00261
    Location:553802
    Tropomyosin; Tropomyosin
    pfam12325
    Location:9761087
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
    pfam12329
    Location:542615
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    cl21478
    Location:646752
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    69019827..69052333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    69056599..69089119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)