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TMF1 TATA element modulatory factor 1 [ Homo sapiens (human) ]

Gene ID: 7110, updated on 6-Jul-2025
Official Symbol
TMF1provided by HGNC
Official Full Name
TATA element modulatory factor 1provided by HGNC
Primary source
HGNC:HGNC:11870
See related
Ensembl:ENSG00000144747 MIM:601126; AllianceGenome:HGNC:11870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMF; ARA160
Summary
Enables nuclear androgen receptor binding activity and transcription coactivator activity. Involved in androgen receptor signaling pathway and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in testis (RPKM 20.2), thyroid (RPKM 13.7) and 25 other tissues See more
Orthologs
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See TMF1 in Genome Data Viewer
Location:
3p14.1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (69019827..69052333, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (69056599..69089119, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (69068978..69101484, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 4 Neighboring gene RNA, 5S ribosomal pseudogene 135 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:68968097-68968699 Neighboring gene Sharpr-MPRA regulatory region 589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14515 Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene EOGT divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20050 Neighboring gene microRNA 3136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14516 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20053 Neighboring gene ubiquitin like modifier activating enzyme 3 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:69152971-69154170 Neighboring gene ARF like GTPase 6 interacting protein 5 Neighboring gene leiomodin 3

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear androgen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Leydig cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within acrosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of epithelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within luteinizing hormone secretion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within male gonad development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of testosterone secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of proteasomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of proteasomal protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within spermatid development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatid nucleus differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
TATA element modulatory factor
Names
androgen receptor coactivator 160 kDa protein
androgen receptor-associated protein of 160 kDa

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363879.1NP_001350808.1  TATA element modulatory factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109587, BC143840, DC401240
    Consensus CDS
    CCDS87105.1
    UniProtKB/TrEMBL
    B4DQY7
    Related
    ENSP00000494067.1, ENST00000646708.1
    Conserved Domains (2) summary
    pfam12325
    Location:9791090
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
    cl25732
    Location:4571093
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_007114.3NP_009045.2  TATA element modulatory factor isoform 1

    See identical proteins and their annotated locations for NP_009045.2

    Status: VALIDATED

    Source sequence(s)
    AB209109, AC109587, AL040699, BC033771, BU689613
    Consensus CDS
    CCDS43105.1
    UniProtKB/Swiss-Prot
    B7ZLJ2, P82094, Q17R87, Q59GK0
    UniProtKB/TrEMBL
    B4DQY7
    Related
    ENSP00000381567.2, ENST00000398559.7
    Conserved Domains (5) summary
    COG4942
    Location:698939
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    pfam00261
    Location:553802
    Tropomyosin; Tropomyosin
    pfam12325
    Location:9761087
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
    pfam12329
    Location:542615
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    cl21478
    Location:646752
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    69019827..69052333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    69056599..69089119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)