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TMF1 TATA element modulatory factor 1 [ Homo sapiens (human) ]

Gene ID: 7110, updated on 7-Jun-2020

Summary

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Official Symbol
TMF1provided by HGNC
Official Full Name
TATA element modulatory factor 1provided by HGNC
Primary source
HGNC:HGNC:11870
See related
Ensembl:ENSG00000144747 MIM:601126
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMF; ARA160
Expression
Ubiquitous expression in testis (RPKM 20.2), thyroid (RPKM 13.7) and 25 other tissues See more
Orthologs
mouse all

Genomic context

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See TMF1 in Genome Data Viewer
Location:
3p14.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (69019827..69052333, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (69068978..69101484, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 4 Neighboring gene RNA, 5S ribosomal pseudogene 135 Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene microRNA 3136 Neighboring gene ubiquitin like modifier activating enzyme 3 Neighboring gene ADP ribosylation factor like GTPase 6 interacting protein 5 Neighboring gene leiomodin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular insights into vesicle tethering at the Golgi by the conserved oligomeric Golgi (COG) complex and the golgin TATA element modulatory factor (TMF). Miller VJ, et al. J Biol Chem, 2013 Feb 8. PMID 23239882, Free PMC Article
  2. TMF/ARA160 downregulates proangiogenic genes and attenuates the progression of PC3 xenografts. Abrham G, et al. Int J Cancer, 2009 Jul 1. PMID 19330832
  3. Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic. Yamane J, et al. Exp Cell Res, 2007 Oct 1. PMID 17698061
  4. Cloning and chromosomal mapping of a human immunodeficiency virus 1 "TATA" element modulatory factor. Garcia JA, et al. Proc Natl Acad Sci U S A, 1992 Oct 15. PMID 1409643, Free PMC Article
  5. PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1. Papadopoulos N, et al. J Cell Biol, 2018 May 7. PMID 29545370, Free PMC Article

See all (37) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In the nucleus, PDGFRbeta formed ligand-inducible complexes with the tyrosine kinase Fer and its substrate, TATA element-modifying factor 1 (TMF-1).
    Title: PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.
  2. In patient with chronic granulomatous disease, a 5.8-kb, incomplete and partly exonized TMF1 transcript was identified in intron 1 of CYBB, in opposite orientation to the host gene.
    Title: Primary immunodeficiency caused by an exonized retroposed gene copy inserted in the CYBB gene.
  3. COG complex interacts with two different Rabs in addition to each end of the golgin "TATA element modulatory factor" (TMF).
    Title: Molecular insights into vesicle tethering at the Golgi by the conserved oligomeric Golgi (COG) complex and the golgin TATA element modulatory factor (TMF).
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. Overexpression of TMF/ARA160 downregulates proangiogenic genes and attenuates the progression of prostate cancer xenografts.
    Title: TMF/ARA160 downregulates proangiogenic genes and attenuates the progression of PC3 xenografts.
  6. These observations suggest critical roles for TMF in two Rab6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the endoplasmic reticulum.
    Title: Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
  
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
transcription coregulator activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
Leydig cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acrosome assembly IEA
Inferred from Electronic Annotation
more info
  
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
  
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
  
luteinizing hormone secretion IEA
Inferred from Electronic Annotation
more info
  
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
  
positive regulation of testosterone secretion IEA
Inferred from Electronic Annotation
more info
  
regulation of proteasomal protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
 PubMed 
spermatid nucleus differentiation IEA
Inferred from Electronic Annotation
more info
  
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
  
Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
cytosol TAS
Traceable Author Statement
more info
  
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TATA element modulatory factor
Names
androgen receptor coactivator 160 kDa protein
androgen receptor-associated protein of 160 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363879.1 → NP_001350808.1  TATA element modulatory factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109587, BC143840, DC401240
    Consensus CDS
    CCDS87105.1
    Related
    ENSP00000494067.1, ENST00000646708.1
    Conserved Domains (2) summary
    pfam12325
    Location:979 → 1090
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
    cl25732
    Location:457 → 1093
    SMC_N; RecF/RecN/SMC N terminal domain

  2. NM_007114.3 → NP_009045.2  TATA element modulatory factor isoform 1

    See identical proteins and their annotated locations for NP_009045.2

    Status: VALIDATED

    Source sequence(s)
    AB209109, AC109587, AL040699, BC033771, BU689613
    Consensus CDS
    CCDS43105.1
    UniProtKB/Swiss-Prot
    P82094
    UniProtKB/TrEMBL
    A0A024R370, Q6PII6
    Related
    ENSP00000381567.2, ENST00000398559.7
    Conserved Domains (5) summary
    COG4942
    Location:698 → 939
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    pfam00261
    Location:553 → 802
    Tropomyosin; Tropomyosin
    pfam12325
    Location:976 → 1087
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
    pfam12329
    Location:542 → 615
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    cl21478
    Location:646 → 752
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    69019827..69052333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P82094.2 GenPept UniProtKB/Swiss-Prot:P82094

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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