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TMF1 TATA element modulatory factor 1 [ Homo sapiens (human) ]

Gene ID: 7110, updated on 11-Sep-2019

Summary

Official Symbol
TMF1provided by HGNC
Official Full Name
TATA element modulatory factor 1provided by HGNC
Primary source
HGNC:HGNC:11870
See related
Ensembl:ENSG00000144747 MIM:601126
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMF; ARA160
Expression
Ubiquitous expression in testis (RPKM 20.2), thyroid (RPKM 13.7) and 25 other tissues See more
Orthologs

Genomic context

See TMF1 in Genome Data Viewer
Location:
3p14.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (69019827..69052333, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (69068978..69101484, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 4 Neighboring gene RNA, 5S ribosomal pseudogene 135 Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene microRNA 3136 Neighboring gene ubiquitin like modifier activating enzyme 3 Neighboring gene ADP ribosylation factor like GTPase 6 interacting protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coregulator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Leydig cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acrosome assembly IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
luteinizing hormone secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of testosterone secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of proteasomal protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
spermatid nucleus differentiation IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TATA element modulatory factor
Names
androgen receptor coactivator 160 kDa protein
androgen receptor-associated protein of 160 kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363879.1NP_001350808.1  TATA element modulatory factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109587, BC143840, DC401240
    Consensus CDS
    CCDS87105.1
    Related
    ENSP00000494067.1, ENST00000646708.1
    Conserved Domains (2) summary
    pfam12325
    Location:9791090
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
    cl25732
    Location:4571093
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_007114.3NP_009045.2  TATA element modulatory factor isoform 1

    See identical proteins and their annotated locations for NP_009045.2

    Status: VALIDATED

    Source sequence(s)
    AB209109, AC109587, AL040699, BC033771, BU689613
    Consensus CDS
    CCDS43105.1
    UniProtKB/Swiss-Prot
    P82094
    UniProtKB/TrEMBL
    A0A024R370, Q6PII6
    Related
    ENSP00000381567.2, ENST00000398559.7
    Conserved Domains (5) summary
    COG4942
    Location:698939
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    pfam00261
    Location:553802
    Tropomyosin; Tropomyosin
    pfam12325
    Location:9761087
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
    pfam12329
    Location:542615
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    cl21478
    Location:646752
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    69019827..69052333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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