U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Arhgap19 Rho GTPase activating protein 19 [ Mus musculus (house mouse) ]

Gene ID: 71085, updated on 12-May-2024

Summary

Official Symbol
Arhgap19provided by MGI
Official Full Name
Rho GTPase activating protein 19provided by MGI
Primary source
MGI:MGI:1918335
See related
Ensembl:ENSMUSG00000025154 AllianceGenome:MGI:1918335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mFLJ00368; 4933411B03Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; male reproductive gland or organ; and trigeminal nerve. Orthologous to human ARHGAP19 (Rho GTPase activating protein 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 16.1), testis adult (RPKM 15.6) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Arhgap19 in Genome Data Viewer
Location:
19 C3; 19 35.19 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (41755027..41790523, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (41766588..41802084, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene slit guidance ligand 1 Neighboring gene predicted gene, 34116 Neighboring gene VISTA enhancer mm1552 Neighboring gene predicted gene, 19424 Neighboring gene STARR-seq mESC enhancer starr_46160 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:41843349-41843458 Neighboring gene STARR-seq mESC enhancer starr_46161 Neighboring gene STARR-positive B cell enhancer ABC_E7656 Neighboring gene predicted gene, 41847 Neighboring gene STARR-positive B cell enhancer ABC_E7657 Neighboring gene STARR-seq mESC enhancer starr_46163 Neighboring gene frequently rearranged in advanced T cell lymphomas

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Spontaneous (1)  1 citation
  • Targeted (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ00368

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 19
Names
rho-type GTPase-activating protein 19

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163495.1NP_001156967.1  rho GTPase-activating protein 19 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC145557, BC086680
    Consensus CDS
    CCDS50435.1
    UniProtKB/TrEMBL
    E9Q4T1
    Related
    ENSMUSP00000129586.2, ENSMUST00000163265.9
    Conserved Domains (1) summary
    cd04392
    Location:113320
    RhoGAP_ARHGAP19; RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...
  2. NM_027667.3NP_081943.2  rho GTPase-activating protein 19 isoform 1

    See identical proteins and their annotated locations for NP_081943.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC145557, BC086680
    Consensus CDS
    CCDS37989.1
    UniProtKB/Swiss-Prot
    B9EI55, Q0VGS7, Q5DU53, Q8BRH3, Q9D468
    Related
    ENSMUSP00000026150.9, ENSMUST00000026150.15
    Conserved Domains (1) summary
    cd04392
    Location:113320
    RhoGAP_ARHGAP19; RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    41755027..41790523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161690.1XP_036017583.1  rho GTPase-activating protein 19 isoform X6

    Conserved Domains (1) summary
    cd04392
    Location:107293
    RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...
  2. XM_036161689.1XP_036017582.1  rho GTPase-activating protein 19 isoform X5

  3. XM_011247341.2XP_011245643.1  rho GTPase-activating protein 19 isoform X1

    Conserved Domains (1) summary
    cd04392
    Location:104311
    RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...
  4. XM_011247343.2XP_011245645.1  rho GTPase-activating protein 19 isoform X3

    Conserved Domains (1) summary
    cd04392
    Location:104311
    RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...
  5. XM_011247342.2XP_011245644.1  rho GTPase-activating protein 19 isoform X2

    Conserved Domains (1) summary
    cd04392
    Location:104311
    RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...
  6. XM_011247344.4XP_011245646.3  rho GTPase-activating protein 19 isoform X4

    Conserved Domains (1) summary
    cd04392
    Location:98284
    RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...