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ARHGAP19 Rho GTPase activating protein 19 [ Homo sapiens (human) ]

Gene ID: 84986, updated on 12-Oct-2019

Summary

Official Symbol
ARHGAP19provided by HGNC
Official Full Name
Rho GTPase activating protein 19provided by HGNC
Primary source
HGNC:HGNC:23724
See related
Ensembl:ENSG00000213390 MIM:611587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 13.6), bone marrow (RPKM 8.1) and 24 other tissues See more
Orthologs

Genomic context

See ARHGAP19 in Genome Data Viewer
Location:
10q24.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (97222173..97292673, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (98981930..99052430, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene slit guidance ligand 1 Neighboring gene SLIT1 antisense RNA 1 Neighboring gene ARHGAP19-SLIT1 readthrough (NMD candidate) Neighboring gene uncharacterized LOC112268065 Neighboring gene uncharacterized LOC105378447 Neighboring gene ribosomal protein L12 pseudogene 27 Neighboring gene FRAT regulator of WNT signaling pathway 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ARHGAP19-SLIT1

Readthrough gene: ARHGAP19-SLIT1, Included gene: SLIT1

Homology

Clone Names

  • MGC14258, MGC138804, MGC138805, DKFZp313K217

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 19
Names
putative RhoGAP protein
rho-type GTPase-activating protein 19

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204300.1NP_001191229.1  rho GTPase-activating protein 19 isoform 2

    See identical proteins and their annotated locations for NP_001191229.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK074122, AL359385, BC113888, BX648194, CD743029
    Consensus CDS
    CCDS73175.1
    UniProtKB/Swiss-Prot
    Q14CB8
    Related
    ENSP00000351058.4, ENST00000358308.7
    Conserved Domains (1) summary
    cd04392
    Location:113291
    RhoGAP_ARHGAP19; RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...
  2. NM_001256423.2NP_001243352.1  rho GTPase-activating protein 19 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, compared to variant 1, resulting in an isoform (3) that has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL359385
    Consensus CDS
    CCDS58092.1
    UniProtKB/Swiss-Prot
    Q14CB8
    Related
    ENSP00000360066.1, ENST00000371027.5
    Conserved Domains (1) summary
    cd04392
    Location:104311
    RhoGAP_ARHGAP19; RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...
  3. NM_032900.6NP_116289.4  rho GTPase-activating protein 19 isoform 1

    See identical proteins and their annotated locations for NP_116289.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL359385
    Consensus CDS
    CCDS7454.2
    UniProtKB/Swiss-Prot
    Q14CB8
    Related
    ENSP00000351333.4, ENST00000358531.9
    Conserved Domains (1) summary
    cd04392
    Location:113320
    RhoGAP_ARHGAP19; RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    97222173..97292673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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