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Ankib1 ankyrin repeat and IBR domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 70797, updated on 7-May-2024

Summary

Official Symbol
Ankib1provided by MGI
Official Full Name
ankyrin repeat and IBR domain containing 1provided by MGI
Primary source
MGI:MGI:1918047
See related
Ensembl:ENSMUSG00000040351 AllianceGenome:MGI:1918047
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1386; 2310061P20Rik; 4631416I11Rik
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human ANKIB1 (ankyrin repeat and IBR domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 7.8), CNS E18 (RPKM 6.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
5 A1; 5 2.26 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (3739999..3853124, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (3689999..3803124, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12316 Neighboring gene GATA zinc finger domain containing 1 Neighboring gene predicted gene, 50624 Neighboring gene STARR-seq mESC enhancer starr_12317 Neighboring gene transmembrane BAX inhibitor motif containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E4742 Neighboring gene STARR-seq mESC enhancer starr_12318 Neighboring gene KRIT1, ankyrin repeat containing Neighboring gene leucine rich repeats and death domain containing 1 Neighboring gene mitochondrial transcription termination factor 1a

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC90780

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ankyrin repeat and IBR domain-containing protein 1
NP_001003909.2
NP_001276456.1
NP_001276457.1
NP_001276458.1
XP_017176586.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003909.4NP_001003909.2  ankyrin repeat and IBR domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001003909.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC022236
    Consensus CDS
    CCDS51408.1
    UniProtKB/Swiss-Prot
    Q6AXE1, Q6ZPS6
    UniProtKB/TrEMBL
    B2RX15
    Related
    ENSMUSP00000040946.7, ENSMUST00000043551.11
    Conserved Domains (5) summary
    cd00204
    Location:47198
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01485
    Location:403476
    IBR; IBR domain, a half RING-finger domain
    pfam12796
    Location:50176
    Ank_2; Ankyrin repeats (3 copies)
    pfam13639
    Location:334380
    zf-RING_2; Ring finger domain
    sd00045
    Location:4777
    ANK; ANK repeat [structural motif]
  2. NM_001289527.1NP_001276456.1  ankyrin repeat and IBR domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001276456.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC022236
    UniProtKB/TrEMBL
    B2RX15
    Conserved Domains (4) summary
    COG0666
    Location:28199
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:4777
    ANK; ANK repeat [structural motif]
    cd16774
    Location:333389
    RING-HC_RBR_ANKIB1; RING finger, HC subclass, found in ankyrin repeat and IBR domain-containing protein 1 (ANKIB1) and similar proteins
    pfam01485
    Location:403476
    IBR; IBR domain, a half RING-finger domain
  3. NM_001289528.1NP_001276457.1  ankyrin repeat and IBR domain-containing protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' region and uses an alternate in-frame splice site in the 3' region, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (3) has a shorter N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC022236, BC079620, BC145510, CN526058
    UniProtKB/Swiss-Prot
    Q6ZPS6
    Conserved Domains (2) summary
    pfam01485
    Location:129202
    IBR; IBR domain, a half RING-finger domain
    pfam13639
    Location:60106
    zf-RING_2; Ring finger domain
  4. NM_001289529.1NP_001276458.1  ankyrin repeat and IBR domain-containing protein 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' UTR and contains an alternate exon in the 5' region, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (4) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK014523, BC079620, BC089031, CN526058
    UniProtKB/Swiss-Prot
    Q6ZPS6
    Conserved Domains (1) summary
    pfam01485
    Location:1162
    IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    3739999..3853124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321097.1XP_017176586.1  ankyrin repeat and IBR domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    B2RX15
    Conserved Domains (4) summary
    COG0666
    Location:28199
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:4777
    ANK; ANK repeat [structural motif]
    cd16774
    Location:333389
    RING-HC_RBR_ANKIB1; RING finger, HC subclass, found in ankyrin repeat and IBR domain-containing protein 1 (ANKIB1) and similar proteins
    pfam01485
    Location:403476
    IBR; IBR domain, a half RING-finger domain