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ANKIB1 ankyrin repeat and IBR domain containing 1 [ Homo sapiens (human) ]

Gene ID: 54467, updated on 10-Dec-2019

Summary

Official Symbol
ANKIB1provided by HGNC
Official Full Name
ankyrin repeat and IBR domain containing 1provided by HGNC
Primary source
HGNC:HGNC:22215
See related
Ensembl:ENSG00000001629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in brain (RPKM 9.0), testis (RPKM 8.7) and 25 other tissues See more
Orthologs

Genomic context

See ANKIB1 in Genome Data Viewer
Location:
7q21.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (92245974..92401383)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (91875530..92030698)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CYP51A1 antisense RNA 1 Neighboring gene leucine rich repeats and death domain containing 1 Neighboring gene microRNA 1285-1 Neighboring gene KRIT1 ankyrin repeat containing Neighboring gene Sharpr-MPRA regulatory region 5961 Neighboring gene transmembrane BAX inhibitor motif containing 7, pseudogene Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33123, KIAA1386, DKFZp434A0225

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ankyrin repeat and IBR domain-containing protein 1
NP_061877.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019004.2NP_061877.1  ankyrin repeat and IBR domain-containing protein 1

    See identical proteins and their annotated locations for NP_061877.1

    Status: VALIDATED

    Source sequence(s)
    AB037807, AC000120, AC007566, BC063861
    Consensus CDS
    CCDS47639.1
    UniProtKB/Swiss-Prot
    Q9P2G1
    Related
    ENSP00000265742.3, ENST00000265742.8
    Conserved Domains (5) summary
    cd00204
    Location:47194
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01485
    Location:402475
    IBR; IBR domain, a half RING-finger domain
    pfam12796
    Location:50175
    Ank_2; Ankyrin repeats (3 copies)
    pfam13639
    Location:333379
    zf-RING_2; Ring finger domain
    sd00045
    Location:4776
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    92245974..92401383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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