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THRB thyroid hormone receptor beta [ Homo sapiens (human) ]

Gene ID: 7068, updated on 26-Nov-2021

Summary

Official Symbol
THRBprovided by HGNC
Official Full Name
thyroid hormone receptor betaprovided by HGNC
Primary source
HGNC:HGNC:11799
See related
Ensembl:ENSG00000151090 MIM:190160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRTH; PRTH; THR1; ERBA2; NR1A2; THRB1; THRB2; TRbeta; C-ERBA-2; C-ERBA-BETA
Summary
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 8.1), fat (RPKM 4.3) and 22 other tissues See more
Orthologs
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Genomic context

See THRB in Genome Data Viewer
Location:
3p24.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (24117153..24495708, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (24158644..24537199, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 691 Neighboring gene nucleophosmin 1 pseudogene 23 Neighboring gene THRB antisense RNA 2 Neighboring gene GATA motif-containing MPRA enhancer 252 Neighboring gene Sharpr-MPRA regulatory region 12793 Neighboring gene HNF4 motif-containing MPRA enhancer 120 Neighboring gene ribosomal protein L31 pseudogene 20 Neighboring gene uncharacterized LOC107986011 Neighboring gene THRB antisense RNA 1 Neighboring gene eukaryotic translation initiation factor 3 subunit K pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
GeneReviews: Not available
Genome-wide association study of hematological and biochemical traits in a Japanese population.
GeneReviews: Not available
Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
GeneReviews: Not available
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
GeneReviews: Not available
Seventy-five genetic loci influencing the human red blood cell.
GeneReviews: Not available
Thyroid hormone resistance, generalized, autosomal dominant
MedGen: C2937288 OMIM: 188570 GeneReviews: Not available
Compare labs
Thyroid hormone resistance, generalized, autosomal recessive
MedGen: C3489796 OMIM: 274300 GeneReviews: Not available
Compare labs
Thyroid hormone resistance, selective pituitary
MedGen: C1840364 OMIM: 145650 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126109, MGC126110

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables thyroid hormone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to thyroid hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in female courtship behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of female receptivity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of thyroid hormone mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of heart contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in retinal cone cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in retinal cone cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
involved_in thyroid hormone mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
involved_in type I pneumocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
thyroid hormone receptor beta
Names
nuclear receptor subfamily 1 group A member 2
oncogene ERBA2
thyroid hormone nuclear receptor beta variant 1
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009159.1 RefSeqGene

    Range
    4973..382670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000461.5NP_000452.2  thyroid hormone receptor beta isoform a

    See identical proteins and their annotated locations for NP_000452.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (a). Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AC012087, AC098971, AK095776, AW449568, BC028910, BC106929, BP313943, M26747
    Consensus CDS
    CCDS2641.1
    UniProtKB/Swiss-Prot
    P10828
    UniProtKB/TrEMBL
    F1D8N7
    Related
    ENSP00000379904.2, ENST00000396671.7
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  2. NM_001128176.3NP_001121648.1  thyroid hormone receptor beta isoform a

    See identical proteins and their annotated locations for NP_001121648.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AC012087, AC098971, AW449568, AY286468, BC106930, GQ869477
    Consensus CDS
    CCDS2641.1
    UniProtKB/Swiss-Prot
    P10828
    UniProtKB/TrEMBL
    F1D8N7
    Related
    ENSP00000348827.4, ENST00000356447.9
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  3. NM_001128177.2NP_001121649.1  thyroid hormone receptor beta isoform a

    See identical proteins and their annotated locations for NP_001121649.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AC012087, AC098971, AK095776, AK096628, AW449568, BC028910, M26747
    Consensus CDS
    CCDS2641.1
    UniProtKB/Swiss-Prot
    P10828
    UniProtKB/TrEMBL
    F1D8N7
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  4. NM_001252634.2NP_001239563.1  thyroid hormone receptor beta isoform a

    See identical proteins and their annotated locations for NP_001239563.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AC012087, AC098971, AK096628, AW449568, GQ869477
    Consensus CDS
    CCDS2641.1
    UniProtKB/Swiss-Prot
    P10828
    UniProtKB/TrEMBL
    F1D8N7
    Related
    ENSP00000414444.1, ENST00000416420.5
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  5. NM_001354708.2NP_001341637.1  thyroid hormone receptor beta isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AC012087, AC093927, AC098971, AC099054
    Consensus CDS
    CCDS2641.1
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  6. NM_001354709.2NP_001341638.1  thyroid hormone receptor beta isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AC012087, AC093927, AC098971, AC099054
    Consensus CDS
    CCDS2641.1
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  7. NM_001354710.2NP_001341639.1  thyroid hormone receptor beta isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AC012087, AC093927, AC098971, AC099054
    Consensus CDS
    CCDS2641.1
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  8. NM_001354711.2NP_001341640.1  thyroid hormone receptor beta isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AC012087, AC093927, AC098971, AC099054
    Consensus CDS
    CCDS2641.1
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  9. NM_001354712.2NP_001341641.1  thyroid hormone receptor beta isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AC012087, AC093927, AC098971, AC099054
    Consensus CDS
    CCDS2641.1
    Related
    ENSP00000496686.2, ENST00000646209.2
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  10. NM_001354713.2NP_001341642.1  thyroid hormone receptor beta isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AC012087, AC093927, AC098971, AC099054
    Consensus CDS
    CCDS2641.1
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  11. NM_001354714.2NP_001341643.1  thyroid hormone receptor beta isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC012087, AC093927, AC098971, AC099054
    Conserved Domains (2) summary
    cd06935
    Location:185427
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:75161
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  12. NM_001354715.2NP_001341644.1  thyroid hormone receptor beta isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC012087, AC093927, AC098971, AC099054
    Conserved Domains (2) summary
    cd06935
    Location:185427
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:75161
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  13. NM_001374822.1NP_001361751.1  thyroid hormone receptor beta isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 1-10 and 14-17, encodes isoform a.
    Source sequence(s)
    AC012087, AC093927, AC098971, AC099054
    Related
    ENSP00000493709.1, ENST00000645139.1
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  14. NM_001374823.1NP_001361752.1  thyroid hormone receptor beta isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 1-10, 13, and 15-17, encodes isoform a.
    Source sequence(s)
    AC012087, AC093927, AC098971, AC099054
    Related
    ENSP00000494618.1, ENST00000642307.1
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  15. NM_001374824.1NP_001361753.1  thyroid hormone receptor beta isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 1-10, 13, 14, 16, and 17, encodes isoform a.
    Source sequence(s)
    AC012087, AC093927, AC098971, AC099054
    Related
    ENSP00000496029.1, ENST00000643772.1
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  16. NM_001374825.1NP_001361754.1  thyroid hormone receptor beta isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 1-10, 13-15, and 17, encodes isoform a.
    Source sequence(s)
    AC012087, AC093927, AC098971, AC099054
    Related
    ENSP00000496616.1, ENST00000644321.1
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  17. NM_001374826.1NP_001361755.1  thyroid hormone receptor beta isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 1-10 and 13-16, encodes isoform a.
    Source sequence(s)
    AC012087, AC093927, AC098971, AC099054
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  18. NM_001374827.1NP_001361756.1  thyroid hormone receptor beta isoform c

    Status: REVIEWED

    Source sequence(s)
    AC012087, AC093927, AC098971, AC099054
    Conserved Domains (2) summary
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    cl11397
    Location:216401
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    24117153..24495708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534047.3XP_011532349.1  thyroid hormone receptor beta isoform X1

    See identical proteins and their annotated locations for XP_011532349.1

    UniProtKB/Swiss-Prot
    P10828
    UniProtKB/TrEMBL
    F1D8N7
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  2. XM_024453738.1XP_024309506.1  thyroid hormone receptor beta isoform X1

    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  3. XM_011534053.2XP_011532355.1  thyroid hormone receptor beta isoform X2

    Conserved Domains (2) summary
    cd06935
    Location:185427
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:75161
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  4. XM_024453734.1XP_024309502.1  thyroid hormone receptor beta isoform X1

    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  5. XM_024453735.1XP_024309503.1  thyroid hormone receptor beta isoform X1

    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  6. XM_017007113.1XP_016862602.1  thyroid hormone receptor beta isoform X2

    Conserved Domains (2) summary
    cd06935
    Location:185427
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:75161
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  7. XM_011534050.2XP_011532352.1  thyroid hormone receptor beta isoform X1

    See identical proteins and their annotated locations for XP_011532352.1

    UniProtKB/Swiss-Prot
    P10828
    UniProtKB/TrEMBL
    F1D8N7
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  8. XM_006713318.3XP_006713381.1  thyroid hormone receptor beta isoform X1

    See identical proteins and their annotated locations for XP_006713381.1

    UniProtKB/Swiss-Prot
    P10828
    UniProtKB/TrEMBL
    F1D8N7
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  9. XM_017007109.1XP_016862598.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P10828
    UniProtKB/TrEMBL
    F1D8N7
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  10. XM_024453733.1XP_024309501.1  thyroid hormone receptor beta isoform X1

    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  11. XM_024453737.1XP_024309505.1  thyroid hormone receptor beta isoform X1

    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  12. XM_017007111.1XP_016862600.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P10828
    UniProtKB/TrEMBL
    F1D8N7
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  13. XM_011534052.2XP_011532354.1  thyroid hormone receptor beta isoform X1

    See identical proteins and their annotated locations for XP_011532354.1

    UniProtKB/Swiss-Prot
    P10828
    UniProtKB/TrEMBL
    F1D8N7
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  14. XM_024453736.1XP_024309504.1  thyroid hormone receptor beta isoform X1

    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
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